Healthy gut and healthy heart: 专 Nexus funds second round of grants
Now well into its first year, 专 Nexus announced a new round of grants totaling $550,000 for collaborative projects from researchers at 欧美口爆视频 Boulder and 欧美口爆视频 Anschutz that aim to improve human wellbeing through basic science and translational research approaches.
The grant program is supported by the president鈥檚 office and leadership at both campuses to create opportunities for 欧美口爆视频 Boulder and 欧美口爆视频 Anschutz experts to collaborate and drive innovation.
鈥淭he 专 Nexus initiative continues to advance critical and innovative research that addresses issues affecting human health and quality of life. In the process, it demonstrates the power of inter-campus collaboration and the far-reaching impact of research happening at the University of 欧美口爆视频,鈥 said 欧美口爆视频 President Mark Kennedy.
In its second funding cycle, the bi-annual 专 Nexus research collaboration grant program is awarding a total of eight teams鈥搒ix new collaborations that represent innovative research topics and two teams that will advance existing collaborative work in new directions.
鈥淚t is wonderful to see these new and creative project collaborations between researchers at 欧美口爆视频 Anschutz and 欧美口爆视频 Boulder via the 专 Nexus program,鈥 said Thomas Flaig, MD, Vice Chancellor for Research 欧美口爆视频 Denver | Anschutz. 鈥淚 believe there is great continued growth potential in these interdisciplinary interactions.鈥
Research teams selected explore transformational ideas that are poised to capture external funding. 专 Nexus enables these teams to acquire preliminary data needed to pursue larger opportunities.
鈥淎warded teams showed how they will leverage this initial 专 Nexus support to attract future external funding,鈥 said Terri Fiez, vice chancellor for research and innovation at 欧美口爆视频 Boulder, 鈥渋ncluding timelines for pursuing specific calls for proposals that often grow in scale and impact.鈥
The embodies these 专 Nexus goals, with examples including:
Microbiome and health
Diverse health conditions like obesity, anxiety and cancer may link to our gut microbiome. In the colon, mucus acts as a barrier, preventing harmful microorganisms from entering the body and causing damage. The project, 鈥淪wimming through mucus: Anisotropy and other obstacles for bacteria鈥 will identify how some microorganisms penetrate the protective mucus layer.
The new collaboration will establish a strong interdisciplinary foundation between biophysics and mucosal defense research. Using the data acquired, the team plans to pursue additional funding opportunities sponsored by NSF, joint NSF-NIH, DOD and foundations. Research discoveries made through this initial study will fuel future plans to expand the team to examine treatment strategies, such as drug delivery across the mucus layer.
Principal investigators for the project, which was awarded $50,000, are Nuris Figueroa, assistant professor in the Department of Physics at 欧美口爆视频 Boulder, and Christopher Evans, professor in the Division of Pulmonary Sciences and Critical Care Medicine at 欧美口爆视频 Anschutz.
Preventing cardiovascular disease
The development of fibrous connective tissue after heart injury can result in scarring, stiffening and organ failure. Of only two FDA-approved treatments to prevent fibrosis, neither have significant impact on patient quality of life, symptoms or mortality. An existing collaboration, 鈥淏iomaterial and Small Molecule Targeting of Macrophage BRD4 to Prevent Pathological Cardiac Fibrosis,鈥 was awarded $125,000 to pursue outside-the-box ideas to develop innovative therapies.
The multidisciplinary team includes expertise in bioengineering, biomaterials, epigenetics, inflammation, drug discovery and cardiac biology. The study will uncover new information about the mechanism of fibrosis and inform multiple new therapeutic innovations for patients with chronic fibrosis in end-stage cardiac diseases. With these findings, the team will apply for larger-scale NIH funding, as well as pursue SBIR/STTR opportunities and industry sponsorship.
Principal investigators for this project are Timothy McKinsey, professor in the Department of Cardiology at 欧美口爆视频 Anschutz, Kristi Anseth, professor in the Department of Chemical and Biological Engineering at 欧美口爆视频 Boulder and Ronald Vagnozzi, assistant professor in the Department of Cardiology at 欧美口爆视频 Anschutz.
Connected health community
专 Nexus is funded jointly by the 欧美口爆视频 Office of the President, the 欧美口爆视频 Anschutz Office of the Vice Chancellor for Research and the 欧美口爆视频 Boulder Research & Innovation Office.
In addition to the grant program, which will accept a new round of proposals in fall 2021, 专 Nexus provides a variety of resources, including personalized support from partnership specialists, proposal development assistance and funding search training, among others.
To learn more about opportunities to collaborate across campuses, visit the or email diane.ladell@cuanschutz.edu or 鈥kristen.kruszewski@colorado.edu.