Publications

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  1. Kavran AJ, Stuart SA, Hayashi KR, Basken JM, Brandhuber BJ,Ahn NG.(2022).Proc. Natl. Acad. Sci. USA.119:e2113535119. PMID:35290123
  2. Pegram L.M., Anderson J.W., Ahn N.G. (2021)..Curr. Opin. Struct. Biol., 71:215-222. PMID: 34425481
  3. Iverson D.B., Xiao Y., Jones D.N., Eisenmesser E.Z.,Ahn N.G.(2020)Biochemistry,59:2698-2706.PMID:32643366
  4. Lopez E.D.,Burastero O., Arcon J.P., Defelipe L.A.,Ahn N.G., Marti M.A., Turjanski A.G. (2020)J. Chem. Inf. Model.,60:821-832.PMID:31714778
  5. Zhang J., Balsbaugh J.L., Gao S.,Ahn N.G., Klinman J.P. (2020)Proc. Natl. Acad. Sci. USA,117:10797-10805. PMCID:
  6. Pegram L.M., Liddle, J.C., Xiao, Y., Hoh, M., Rudolph, J., Iverson, D.B., Vigers, G.P., Smith, D.L., Zhang, H., Wang, W., Moffat, J.G. and Ahn, N.G. (2019) . Proc. Natl. Acad. Sci. USA, 116:15463-15468. PMCID:PMC6681744
  7. Masson, G.R., Burke, J.E., Ahn, N.G., Anand, G.S., Borchers, C., Brier, S., Bou-Assaf, G.M., Engen, J.R., Englander, S.W., Faber, J., Garlish, R., Griffin, P.R., Gross, M.L., Guttman, M., Hamuro, Y., Heck, A.J.R., Houde, D., Iacob, R.E., Jørgensen, T.J.D., Kaltashov, I.A., Klinman, J.P., Konermann, L., Man, P., Mayne, L., Pascal, B.D., Reichmann, D., Skehel, M., Snijder, J., Strutzenberg, T.S., Underbakke, E.S., Wagner, C., Wales, T.E., Walters, B.T., Weis, D.D., Wilson, D.J., Wintrode, P.L., Zhang, Z., Zheng, J., Schriemer, D.C. and Rand K.D. (2019) Nat. Methods 16:595-602. PMCID:
  8. Basken, J., Stuart, S.A., Kavran, A.J., Lee, T., Ebmeier, C.C., Old, W.M. and Ahn, N.G. (2018) Specificity of phosphorylation responses to MAP kinase pathway inhibitors in melanoma cells. Mol. Cell. Proteomics,17(4):550-564. PMCID:PMC5880111
  9. Mattiroli, F., Bhattacharyya, S., Dyer, P.N., White, A.E., Sandman, K., Burkhart, B.W., Byrne, K.R., Lee, T., Ahn, N.G., Santangelo, T.J., Reeve, J.N. and Luger, K. (2017) Structure of histone based chromatin in Archaea. Science, 357(6351):609-661. PMCID:PMC5747315
  10. Connacher M.K., Tay, J.W. and Ahn, N.G. (2017) Rear-polarized Wnt5a-receptor-actin-myosin-polarity (WRAMP) structures promote the speed and persistence of directional cell migration. Mol. Biol. Cell. 28(14):1924-1936. PMCID: PMC5541843
  11. Mattiroli, F., Gu, Y., Balsbaugh, J.L, Ahn, N.G. and Luger, K. (2017) The Cac2 subunit is essential for productive histone binding and nucleosome assembly in CAF-1. Sci. Rep. 7:46274. PMCID: PMC5394680
  12. Mattiroli F, Gu Y, Yadav T, Balsbaugh JL, Harris MR, Findlay ES, Liu Y, Radebaugh CA, Stargell LA, Ahn NG, Whitehouse I, Luger K. (2017) DNA-mediated association of two histone-bound CAF-1 complexes drives tetrasome assembly in the wake of DNA replication. Elife. 6:e22799. PMCID: PMC5404915
  13. Liu W.H., Roemer, S.C., Zhou, Y., Shen, Z.J., Dennehey, B.K., Balsbaugh, J.L, Liddle, J.C., Nemkov, T. Ahn, N.G., Hansen, K.C., Tyler, J.K. and Churchill, M.E. (2016) The Cac1 subunit of histone chaperon CAF-1 organizes CAF-1-H3/H4 architecture and tetramerizes histones. Elife. 5:e18023. PMCID: PMC5045291
  14. Goshen-Lago, T., Goldberg-Carp, A., Melamed, D., Darlyuk-Saadon, I., Bai, C., Ahn, N.G., Admon, A. and Engelberg, D. (2016) Variants of the yeast MAPK Mpk1 are fully functional independently of activation loop phosphorylation. Mol. Biol. Cell. 27(17):2771-2783. PMCID: PMC5007096
  15. Beenstock, J., Melamed, D., Mooshayef, N., Mordechay, D., Garfinkel, B.P., Ahn, N.G., Admon, A. and Engelberg, D. (2016) p38b mitogen activated protein kinase modulates its own basal activity by autophosphorylation of the activating residue Thr180 and the inhibitory residues Thr241 and Thr261. Mol. Cell Biol. 36(10):1540-1554. PMCID: PMC4859693
  16. Smorodinsky-Atias, K., Goshen-Lago, T., Goldberg-Carp, A., Melamed, D., Shir, A., Mooshayef, N., Beenstock, J., Karamansha, Y., Darlyuk-Saadon, I., Livnah, O., Ahn, N.G., Admon, A. and Engelberg, D. (2016) Mol Biol Cell. 27(6):1026-39. PMID:26658610.
  17. Singh, S.P., Schwartz, M.P., Tokuda, E.Y., Luo, Y., Rogers, R.E., Fujita, M., Ahn, N.G. and Anseth, K.S. (2015) Sci Rep.: 5:17814. PMID:26638791
  18. Xiao, Y., Warner, L.R., Latham, M.P., Ahn, N.G. and Pardi, A. (2015) Structure-based assignment of Ile, Leu and Val methyl groups in the active and inactive forms of the mitogen-activated kinase extracellular signal-regulated kinase 2. Biochemistry 54:4307-4319. PMID: 26132046.
  19. Volkov, V., Grissom, P., Arzhanik, V., Zaytsev, A., Renganathan, K., McClure-Begley, T., Old, W., Ahn, N., and McIntosh, J.R. (2015) Centromere protein F includes two sites that couple efficiently in depolymerizing microtubules. J. Cell Biol. 209:813-828. PMID: 26101217.
  20. Brown, R., Stuart, S., Houel, S., Ahn, N.G. and Old, W.M. (2015) Large-scale examination of factors influencing phosphopeptide neutral loss during collision induced dissociation. J. Am. Soc. Mass Spectrom. 26:1128-1142. PMID: 25851653.
  21. Stuart, S.A., Houel, S., Lee, T., Wang, N., Old, W.M. and Ahn, N.G. (2015) A phosphoproteomic comparison of BRAF(V600E) and MKK1/2 inhibitors in melanoma cells. Mol. Cell. Proteomics, 14:1599-1615. PMID:25850435.
  22. Lee, T., Wang, N., Houel, S., Couts, K., Old, W., and Ahn, N. (2015) Dosage and temporal thresholds in miRNA proteomics. Mol. Cell. Proteomics, 14:289-302. PMID:25467838.
  23. Xiao, Y., Liddle, J.C., Pardi, A. and Ahn, N.G. (2015) Dynamics of protein kinases: Insights from nuclear magnetic resonance. Acc. Chem. Res. 48:1106-1114. PMID:25803188
  24. Long, J., Tokhunts, R., Old, W.M., Houel, S., Rodgriguez-Blanco, J., Singh, S., Shilling, N., Capobianco, A.J., Ahn, N.G., and Robbins, D.J. (2015) Identification of a family of fatty-acid-speciated sonic hedgehog proteins, whose members display differential biological properties. Cell Reports, 10:1280-1287. PMID:25732819.
  25. Rudolph, J., Xiao, Y, Pardi, A. and Ahn, N.G. (2015) Slow inhibition and conformation selective properties of ERK1/2 inhibitors. Biochemistry 54(1):22-31. PMID:25350931.
  26. Sours, K.M., Xiao, Y. and Ahn, N.G. (2014) Extracellular-regulated kinase 2 is activated by the enhancement of hinge flexibility. J. Mol. Biol., 426:1925-1935. PMID: 24534729.
  27. Xiao, Y., Lee, T., Latham, M.P., Warner, L.R., Tanimoto, A., Pardi, A. and Ahn, N.G. (2014) Phosphorylation releases constraints to domain motion in ERK2. Proc. Natl. Acad. Sci. USA, 111(7):2506-2511. PMID: 24550275.
  28. Beenstock, J., Ben-Yehuda, S., Melamed, D., Admon, A., Livnah, O., Ahn, N.G. and Engelberg, D. (2014) The p38b mitogen-activated protein kinase possesses an intrinsic autophosphorylation activity, generated by a short region composed of the aG helix and MAPK insert. J. Biol. Chem., 289(34):23546-23556. PMID:25006254.
  29. Tracy, C.M., Gray, A.J., Cuéllar, J., Shaw, T.S., Howlett, A.C., Taylor, R.M., Prince, J.T., Ahn, N.G., Valpuesta, J.M. and Willardson, B.M. (2014) J. Biol.Chem. 289(7):4490-4502. PMID:24375412
  30. Schwartz, M.P., Rogers, R.E., Singh, S.P., Lee, J.Y., Loveland, S.G., Koepsel, J.T., Witze, E.S., Montanez-Sauri, S.I., Sung, K.E., Tokuda, E.Y., Sharma, Y., Everhart, L.M., Nguyen, E.H., Zaman, M.H., Beebe, D.J., Ahn, N.G., Murphy, W.L. and Anseth, K.S. (2013) A quantitative comparison of human HT1080 fibrosarcoma cells and primary human dermal fibroblasts identifies a 3D migration mechanism with properties unique to the transformed phenotype. PLoS One. 8(12):e81689. PMID: 24349113.
  31. Witze, E.S., Connacher, M.K., Houel, S., Schwartz, M.P., Morphew, M.K., Reid, L., Sacks, D.B., Anseth, K.S. and Ahn, N.G. (2013) Wnt5a directs polarized calcium gradients by recruiting cortical endoplasmic reticulum to the cell trailing edge. Developmental Cell, 26, 645-657. PMID: 24091015
  32. Templeton, P.D., Litman, E.S., Metzner, S.I., Ahn, N.G.* and Sousa, M.C.* (2013) Biochemistry 52(33):5675-5684. PMID: 23859498 (* Corresponding authors)
  33. Ponicsan, S.L., Houel, S., Old, W.M., Ahn, N.G., Goodrich, J.A. and Kugel, J.F. (2013) J. Mol. Biol., 425(19):3625-3638. PMID:23416138.
  34. Couts, K.L., Anderson, E.M., Gross, M.M., Sullivan, K. and Ahn, N.G. (2012) Oncogenic B-Raf signaling in melanoma cells controls a network of microRNAs with combinatorial functions. Oncogene, 32(15):1959-1970. PMID:22751131.
  35. Wang, D., Zhang, Z., O’Loughlin, E., Lee, T., Houel, S., O’Carroll, D., Tarakhovsky, A., Ahn, N.G. and Yi, R. (2012) Quantitative functions of Argonaute proteins in mammalian development. Genes Dev., 26, 693-704. PMID:22474261.
  36. Luo, Y., Ellis, L.Z., Dallaglio, K., Takeda, M., Robinson, W.A., Robinson, S., Lewis, K.D., McCarter, M.D., Gonzalez, R., Norris, D.A., Roop, D.R., Ahn, N.G. and Fujita, M. (2012) Side population cells from human melanoma tumors reveal diverse mechanisms of chemoresistance. J. Invest. Dermatol., 132, 2440-2450. PMID:22622430.
  37. Yen, C.Y., Houel, S., Ahn, N.G., and Old, W.M. (2011) Mol. Cell. Proteomics, 10, M111.007666. PMID:21532008.
  38. Oyeyemi, O.A., Sours, K.M., Lee, T., Kohen, A., Resing, K.A., Ahn, N.G.* and Klinman, J.P.* (2011) Biochemistry, 50, 8251-8260. PMID:21859100 (* Corresponding authors)
  39. Meyer-Arendt, K., Old, W.M., Houel, S., Renganathan, K., Eichelberger, B., Resing, K.A. and Ahn, N.G. (2011) J Proteome Res., 10, 3060-3075. PMID:21599010.
  40. Sours, K.M. and Ahn, N.G. (2010) Analysis of MAP kinases by hydrogen exchange mass spectrometry. In “MAP Kinase Signaling Protocols”, R. Seger, Ed., Methods in Molecular Biology, 661, 239-255.
  41. Ring, A.Y., Sours, K.M., Lee, T. and Ahn, N.G. (2010) Distinct patterns of activation-dependent changes in conformational mobility between ERK1 and ERK2. Intl. J. Mass Spectrometry, 302, 101-109. PMID:21599010.
  42. Houel, S., Abernathy, R., Renganathan, K., Meyer-Arendt, K., Ahn, N.G. and Old, W.M. (2010) Quantifying the impact of chimera MS/MS spectra on peptide identification in large scale proteomics studies. J. Proteome Res., 9, 4152-4160. PMID:20578722.
  43. Oyeyemi, O., Sours, K.M., Lee, T., Resing, K.A., Ahn, N.G.* and Klinman, J.P.* (2010) Temperature dependence of protein motions in a thermophilic dihydrofolate reductase and its relationship to catalytic efficiency. Proc. Natl. Acad. Sci., USA, 107, 10074-10079. PMID:20534574. (* Corresponding authors)
  44. Prince, J.T. and Ahn, N.G. (2010) Molecular Cell, 37, 455-456.
  45. Ahn, N.G. (2009) Nat. Struct. Mol. Biol., 16, 1004-1005.
  46. Kabuyama, Y., Litman, E.S., Templeton, P., Metzner. S.I., Witze, E.S., Argast, G.M., Langer, S.J., Polvinen, K., Shellman, Y, Chan, D., Shabb, J.B., Fitzpatrick, J.E., Resing, K.A., Sousa, M.C. and Ahn, N.G. (2009) A mediator of Rho-dependent signaling in melanoma moonlights as a methionine salvage enzyme. Mol. Cell. Proteomics, 8, 2308-2320. PMID:19620624.
  47. Highlighted by this journal as an “Author’s Choice” article.
  48. Argast, G.M., Croy, C.H., Couts, K.L., Zhang, Z., Litman, E.S., Chan, D.C. and Ahn, N.G. (2009) Cross-regulation of plexin B1 by B-Raf signaling in melanoma cells. Oncogene, 28, 2697-2709. PMID:19483722.
  49. Old, W.M., Shabb, J.S., Houel, S., Wang, H., Couts, K.H., Yen, C-Y., Litman, E.S., Croy, C.H, Meyer-Arendt, K., Miranda, J.G., Brown, R.A., Witze, E.S., Schweppe, R.E., Resing, K.A. and Ahn, N.G. (2009) Functional proteomics identifies targets of phosphorylation by B-Raf signaling in melanoma. Molecular Cell, 34, 115-131. PMID:19362540.
  50. Highlighted as a Molecular Cell Preview (Pawson T. and Taylor L. (2009) Protein phosphorylation goes negative. Molecular Cell. 34:139-140) and as a Nature News & Views article (Huang, P.H. and Marais R. (2009) Melanoma troops massed. Nature 459, 336-337).
  51. Yen, C.-Y., Meyer-Arendt, K., Eichelberger, B., Houel, S., Old, W.M., Knight, R.D., Ahn, N.G., Hunter, L.E. and Resing, K.A. (2008) A theoretical MS/MS library for spectrum-to-spectrum searching in large-scale identification of proteins. Mol. Cell. Proteomics, 8, 857-869. PMID:19106086.
  52. Gehrke, A.S., Sun, S., Kurgan, L., Ahn, N., Resing, K., Kafadar, K. and Cios, K. (2008) Improved machine learning method for analysis of gas phase chemistry of peptides. BMC Bioinformatics, 9, 515-529.
  53. Levin-Salomon, V., Kogan, K., Ahn, N.G., Livnah, O. and Engelberg, D. (2008). Isolation of intrinsically active (MEK- independent) variants of the ERK family of MAP kinases. J. Biol. Chem., 283, 34500-34510. PMID:18829462.
  54. Sours, K.M., Kwok, S.C., Rachidi, T., Lee, T., Ring, A., Hoofnagle, A.N., Resing, K.A. and Ahn, N.G. (2008) Hydrogen exchange mass spectrometry reveals activation-induced changes in conformational mobility of p38a MAP kinase. J. Mol. Biol., 379, 1075-1093. PMID:18501927.
  55. Witze, E.S., Litman, E.S., Argast, G.M., Moon, R.T. and Ahn, N.G. (2008) Wnt5A control of cell polarity and directional movement by polarized redistribution of adhesion receptors. Science, 320, 365-369. PMID:18420933.
  56. Highlighted in Science Perspectives (Bowerman, B. (2008) Wnt moves beyond the canon. Science. 320, 327-328), by Science STKE (Ray, L.B. (2008) Editors’ Choice: Cell biology cellular orienteering. Science Signaling 16, ec147), and as a Research Highlight in Nature Reviews (Kritikow E. (2008) Cell signalling: Dynamic redistribution. Nat.Rev. Mol. Cell Biol., 9, 423).
  57. Ahn, N.G. and Wang, A.H. (2008) Proteomics and genomics: perspectives on drug and target discovery. Curr. Opin. Chem. Biol., 12, 1-3.
  58. Mattison, C.P., Old, W.M., Steiner, E., Huneycutt, B.J., Resing, K.A., Ahn, N.G. and Winey, M. (2007) Mps1 activation loop autophosphorylation enhances kinase activity.J. Biol. Chem., 282, 30553-30561.
  59. Witze, E.S., Old, W.M., Resing, K.A. and Ahn, N.G. (2007) Mapping protein post-translational modifications with mass spectrometry. Nat. Methods, 4, 798-806.
  60. Ahn, N.G., Shabb J.S., Old, W.M. and Resing, K.A. (2007) Achieving in-depth proteomics profiling by mass spectrometry. ACS Chemical Biology, 2, 39-52.
  61. Sun, S., Meyer-Arendt, K., Eichelberger, B., Brown, R., Yen, C.Y., Old, W.M., Pierce, K., Cios, K., Ahn, N.G. and Resing, K.A. (2007) Improved validation of peptide MS/MS assignments using spectral intensity prediction and full annotation of fragment ions. Mol. Cell. Proteomics, 6, 1-17.
  62. Shi, Z., Resing, K.A. and Ahn, N.G. (2006) Networks for the allosteric control of protein kinases. Curr. Op. Struct. Biol.,16, 686-692.
  63. Emrick, M.A., Lee, T., Starkey, P., Mumby, M.C., Resing, K.A. and Ahn, N.G. (2006) The gatekeeper residue in ERK2 controls autoactivation via a pathway of intramolecular connectivity. Proc. Natl. Acad. Sci. USA, 103, 18101-18106.
  64. Schweppe, R.E., Cheung, T.H., and Ahn, N.G. (2006) Global gene expression analysis of ERK5 and ERK1/2 signaling reveals a role for HIF-1 in ERK5-mediated responses. J. Biol. Chem., 281, 20993-21003.
  65. Roberts E.C., Hammond, K., Yin, H., Traish, A.M., Resing, K.A. and Ahn, N.G. (2006) Identification of G2/M targets for the MAP kinase pathway by functional proteomics. Proteomics, 6, 4541-4553.
  66. Ma, Z., Isumi, H., Kanai, M., Kabuyama, Y., Ahn, N.G. and Fukasawa, K. (2006) Mortalin controls centrosome duplication via modulating centrosomal localization of p53. Oncogene, 25, 5377-5390.
  67. Kabuyama, Y., Langer, S.J., Polvinen, K., Homma, Y., Resing, K.A. and Ahn, N.G. (2006) Functional proteomics identifies protein tyrosine phosphatase 1B as a target of RhoA signaling. Mol. Cell. Proteomics, 5, 1359-1367.
  68. Lee, T., Croy, C.H., Resing, K.A. and Ahn, N.G. (2006) Hydrogen exchange measurements in proteins. In "Handbook of Hydrogen Transfer" (Schowen, R.L., Klinman, J.P., eds), Wiley VHC, October 2006, Chapter 14, pp. 1361-1392.
  69. Ruth, M.C., Old, W.M., Emrick, M.A., Meyer-Arendt, K., Aveline-Wolf, L.D., Pierce, K.G., Mendoza, A.M., Sevinsky, J.R., Hamady, M., Knight, R.D., Resing, K.A. and Ahn, N.G. (2006) Analysis of membrane proteins from human chronic myelogenous leukemia cells: Comparison of extraction methods for multidimensional LC-MS/MS. J. Proteome Res., 5, 709-719.
  70. Ruth, M.C., Xu, Y., Maxwell, I.H., Ahn, N.G., Norris, D.A. and Shellman, Y.G. (2006) RhoC promotes human melanoma invasion in a PI3K/Akt-dependent pathway. J. Invest. Dermatol., 126, 862-868.
  71. Yen, C.Y., Russell, S., Mendoza, A.M., Meyer-Arendt, K., Sun, S.J., Cios, K.J., Ahn, N.G. and Resing, K.A. (2006) Improving sensitivity in shotgun proteomics using a peptide-centric database with reduced complexity: Protease cleavage and SCX elution rules from data mining of MS/MS spectra. Anal. Chem., 78, 1071-1084.
  72. Lee, T., Hoofnagle, A.N., Resing, K.A., and Ahn, N.G. (2006) Protein hydrogen exchange measured by electrospray ionization mass spectrometry. in "Cell Biology: A Laboratory Handbook", Third Edition, J.E. Celis, Ed., Elsevier Science. v. 4, 443-449.
  73. Downer, J., Sevinsky, J., Ahn, N., Resing, K. and Betterton, M.D. (2005). Incorporating expression data in metabolic modeling: a case study of lactate dehydrogenase, J. Theoretical Biol., 240, 464-474.
  74. Resing, K.A. and Ahn, N.G. (2005) Proteomics of melanoma cell lines and cultured melanocytes. In "Melanocytes to Melanoma: The Progression to Malignancy" (Hearing, V.J. and Leong, S.P.L., eds), Humana Press, Totowa, New Jersey.pp. 408-426.
  75. Lee, T., Hoofnagle, A.N, Resing, K.A. and Ahn, N.G. (2005) Hydrogen exchange solvent protection by an ATP analogue reveals conformational changes in ERK2 upon activation. J. Mol. Biol., 353, 600-612.
  76. Old, W.M., Meyer-Arendt, K., Aveline-Wolf, K., Pierce, K.G., Mendoza, A., Sevinsky, J.R., Resing, K.A. and Ahn, N.G. (2005) Comparison of label-free methods for quantifying human proteins by shotgun proteomics. Mol. Cell. Proteomics, 4, 1487-1502.
  77. Ahn, N.G. and Resing, K.A. (2005) Lessons in rational drug design for protein kinases.Science, 308, 1266-1267.
  78. Resing, K.A. and Ahn, N.G. (2005) Proteomics strategies for protein identification. FEBS Lett., 579, 885-889.
  79. Resing, K.A. and Ahn, N.G. (2004) Identification of proteins by in-gel digestion and mass spectrometry. in "Proteome Analysis: Interpreting the Genome" D.W. Speicher, Ed., Elsevier Science, Inc., pp. 163-182.
  80. Kabuyama, Y., Resing, K.A. and Ahn, N.G. (2004) Applying proteomics to signaling networks. Curr. Op. Genetics and Dev., 14, 492-498.
  81. Liang, Z.X., Tsigos, I., Lee,T., Bouriotis, V., Resing, K.A., Ahn, N.G. and Klinman J.P. (2004) Evidence for increased local flexibility in psychrophilic alcohol dehydrogenase relative to its thermophilic homologue. Biochemistry, 43, 14676-14683.
  82. Jaspersen, S. L., Huneycutt, B. J., Giddings, Jr., T. H., Resing, K. A., Ahn, N. G. and Winey M. (2004) Cdc28/Cdk1 regulates spindle pole body duplication through phosphorylation of Spc42 and Mps1. Developmental Cell, 7, 263-274.
  83. Resing, K.A., Meyer-Arendt, K., Mendoza, A.M., Aveline-Wolf, L.D., Jonscher, K.R., Pierce, K.G., Old, W.M., Cheung, H.T., Russell, S., Wattawa, J.L., Goehle, G.R., Knight, R.D. and Ahn, N.G. (2004) Improving reproducibility and sensitivity in identifying human proteins by shotgun proteomics. Anal. Chem., 76, 3556-3568.
  84. Liang, Z.-X., Lee, T., Resing, K.A., Ahn, N.G. and Klinman, J.P. (2004) Thermal-activated protein mobility and its correlation with catalysis in thermophilic alcohol dehydrogenase. Proc. Natl. Acad. Sci. USA, 101, 9556-9561.
  85. Kabuyama, Y., Polvinen, K., Resing, K.A. and Ahn, N.G. (2004) Two-dimensional electrophoresis for the identification of signaling targets. in "Signal Transduction Protocols", R.C. Dickson, M. D. Mendenhall, Eds. Methods Mol. Biol. 284, 37-49.
  86. Lee, T., Hoofnagle A. N., Kabuyama, Y., Stroud, J., Min, X., Goldsmith, E.J., Chen, L., Resing, K.A. and Ahn, N.G. (2004) Docking site interactions in MAP kinases revealed by hydrogen exchange mass spectrometry. Molecular Cell, 14, 43-55.
  87. Sevinsky J.R., Whalen, A.M. and Ahn, N.G. (2004) ERK induces the megakaryocyte gene GPIIb/CD41 through MafB/Kreisler. Mol. Cell. Biol., 24, 4534-4545.
  88. Hoofnagle A. N., Resing, K. A. and Ahn, N.G. (2004) Practical methods for deuterium exchange/mass spectrometry. in "MAP kinase protocols", R. Seger, Ed., Methods Mol. Biol., 250, 283-298.
  89. Bernard, K.R., Jonscher, K.R., Resing, K.A. and Ahn, N.G. (2004) Methods in functional proteomics: 2D-PAGE with immobilized pH gradients (IPG), in gel digestion, and identification of proteins by mass spectrometry. in "MAP kinase protocols", R. Seger, Ed., Methods Mol. Biol. 250, 263-282.
  90. Hoofnagle A. N., Stoner, J.W., Lee, T., Eaton, S.S. and Ahn, N.G. (2004) Phosphorylation-dependent changes in structure and dynamics in ERK2 detected by site directed spin labelling and electron paramagnetic resonance. Biophys. J., 86, 395-403.
  91. Haydon, C.E., Eyers, P.A., Wolf, L.A., Resing, K.A., Maller, J.L. and Ahn, N.G. (2003) Identification of novel phosphorylation sites on Xenopus laevis Aurora A and analysis of phosphopeptide enrichment by IMAC. Mol. Cell. Proteomics, 2, 1055-1067.
  92. Bernard, K., Litman, E., Fitzpatrick, J., Shellman,Y., Argast, G., Polvinen, K., Everett, A., Fukasawa, K., Norris, D., Ahn, N.G. and Resing, K.A. (2003) Functional proteomic analysis of melanoma progression. Cancer Res., 63, 6716-6725.
  93. Schweppe, R.E., Melton A.A., Brodsky, K.S., Aveline, L.D., Resing, K.A., Ahn, N.G. and Gutierrez-Hartmann, A. (2003) Purification and mass spectrometric identification of GרP as the functional pituitary Ets factor binding to the basal transcription element of the prolactin promoter. J. Biol. Chem., 278, 16863-16872.
  94. Schweppe R.E., Resing, K. A. and Ahn, N.G. (2003) The characterization of post-translational modifications by mass spectrometry. Accounts Chem. Res., 36, 453-61.
  95. Galasinski S.G., Resing, K.A. and Ahn, N.G. (2003) Histone modifications. Methods, 31, 3-11.
  96. Hoofnagle A. N., Resing, K.A. and Ahn, N.G. (2003) Protein analysis by hydrogen exchange mass spectrometry. Ann. Rev. Biophys. Biomol. Struct., 32, 1-25.
  97. Aurandt, J., Vikis, H.G., Gutkind, J.S., Ahn, N. and Guan, K.L. (2002) The semaphorin receptor plexin B1 signals through a direct interaction with the Rho specific nucleotide exchanger, LARG. Proc. Natl. Acad. Sci. USA, 99, 12085-12090.
  98. Roberts, E.C., Shapiro, P.S., Nahreini, T.S., Pages, G., Pouyssegur, J. and Ahn, N.G. (2002) Distinct cell cycle timing requirements for ERK and PI3K signaling pathways in somatic cell mitosis. Mol. Cell. Biol., 22, 7226-7241.
  99. Vaish, N.K., Dong, F., Andrews, L., Schweppe, R.E., Ahn, N.G., Blatt, L. and Seiwert, S.D. (2002) Monitoring post-translational modification of proteins in solution with allosteric ribozymes. Nature Biotechnology , 20, 810-815.
  100. McLaughlin, J.N., Thulin, C.D., Hart, S.J., Resing, K.A., Ahn, N.G. and Willardson, B.M. (2002) Regulatory interaction of phosducin-like protein with the cytosolic chaperonin complex. Proc. Natl. Acad. Sci. USA, 99, 7962-7967.
  101. Galasinski, S.C., Resing, K.A., Goodrich, J.A. and Ahn, N.G. (2002) Phosphatase inhibition leads to histone deacetylase 1/2 phosphorylation and disruption of co-repressor interactions. J. Biol. Chem., 277, 19618-19626.
  102. Galasinski S., Louie D.F., Gloor, K.K., Resing, K.A. and Ahn, N.G. (2002) Global regulation of post-translational modifications on core histones. J. Biol. Chem., 277, 2579-2588.
  103. Sharma, P., Veeranna, Sharma, M., Amin, N.D., Sihag, R.K., Grant, P., Ahn, N., Kulkarni, A.B. and Pant, H.C. (2002) Phosphorylation of MEK1 by cdk5/p35 down-regulates the mitogen-activated protein kinase pathway. J. Biol. Chem., 277, 528-534.
  104. Ahn, N.G. (2002) MAP kinase. Encyclopedic Reference of Cancer, M. Schwab (Editor), Springer-Verlag, Heidelberg.
  105. Ahn, N.G. (2001) Introduction: protein phosphorylation and signaling. Chem Rev. 101, 2207-8 (N. Ahn, Editor).
  106. Emrick, M.A., Hoofnagle, A.N., Miller, A.S., Ten Eyck, L.F. and Ahn, N.G. (2001) Constitutive activation of extracellular signal-regulated kinase 2 by synergistic point mutations. J. Biol. Chem., 276, 46469-46479.
  107. Thulin, C.D., Savage, J.R., McLaughlin, J.N., Truscott, S.M., Old, W.M., Ahn, N.G., Resing, K.A., Hamm, H.E., Bitensky, M.W. and Willardson, B.M. (2001) Modulation of the G-protein regulator phosducin by Ca2+/calmodulin-dependent protein kinase II phosphorylation and 14-3-3 protein binding. J. Biol. Chem., 276, 23805-23815.
  108. Friedman, D.B., Kern, J.W., Huneycutt, B.J., Vinh D.B.N., Crawford, D.K., Steiner, E., Scheiltz, D., Yates, J., Resing, K.A., Ahn, N.G., Winey, M. and Davis, T.N. (2001) Yeast Mps1p phosphorylates the spindle pole component Spc110p in the N-yerminal domain. J. Biol. Chem., 276, 17958-17967.
  109. Jesch S.A., Lewis, T.S., Ahn, N.G. and Linstedt, A.D. (2001) Mitotic phosphorylation of Golgi reassembly stacking protein 55 by mitogen activated protein kinase ERK2. Mol. Biol. Cell, 12, 1811-1817.
  110. Ahn, N.G., Nahreini, T.S., Tolwinski, N.S. and Resing, K.A. (2001) Pharmacologic inhibitors of MKK1 and MKK2. Methods Enzymology, 332, 417-431.
  111. Ahn, N.G. and Resing, K.A. (2001) Towards the phosphoproteome (News and Views). Nature Biotechnolology, 19, 317-318.
  112. Hoofnagle A.N., Resing, K.A., Goldsmith, E.J. and Ahn, N.G. (2001) Changes in protein conformational mobility upon activation of ERK2, as detected by hydrogen exchange. Proc. Natl. Acad. Sci. USA, 98, 956-961.
  113. Lewis, T.S., Hunt, J., Aveline, L.D., Jonscher, K.R., Louie, D.F., Yeh, J., Nahreini T.S., Resing, K.A. and Ahn, N.G. (2000) Identification of novel MAP kinase pathway signaling targets by functional proteomics and mass spectrometry. Molecular Cell, 6, 1343-1354.
  114. Seiwert, S., Nahreini, T.S., Aigner, S., Ahn, N.G. and Uhlenbeck O.C. (2000) RNA aptamers as pathway-specific MAP kinase inhibitors. Chemistry and Biology, 7, 833-843.
  115. Prowse, C.N., Hagopian, J.C., Cobb, M.H., Ahn, N.G. and Lew J. (2000) Catalytic reaction pathway for the mitogen-activated protein kinase, ERK2. Biochemistry, 39, 6258-6266.
  116. Rak, J., Mitsuhashi, Y., Sheehan, C., Tamir, A., Viloria-Petit, A., Filmus, J., Mansour, S.J., Ahn, N.G. Kerbel, R.S. (2000) Oncogenes and tumor angiogenesis: differential modes of vascular endothelial growth factor up-regulation in ras-transformed epithelial cells and fibroblasts. Cancer Res., 60, 490-498.
  117. Louie, D.F., Gloor, K.K., Galasinski, S.C., Resing, K.A. and Ahn, N.G. (2000) Phosphorylation and subcellular redistribution of high mobility group proteins 14 and 17, analyzed by mass spectrometry. Protein Sci., 9, 170-179.
  118. Holmström, T.H., Johnson, V.L., Tran, S., Ahn, N.G., Chow, S.C. and Eriksson, J.E. (1999) Inhibition of mitogen-activated kinase signaling sensitizes tumor cells to Fas receptor-mediated apoptosis. Mol. Cell. Biol., 19, 5991-6002.
  119. Boeshans, K.M., Resing, K.A., Hunt, J.B., Ahn, N.G. and Shabb, J.B. (1999) Structural characterization of the membrane-associated regulatory subunit of type I cAMP dependent protein kinase by mass spectrometry: Identification of Ser81 as the in vivo phosphorylation site of RIa. Protein Sci., 8, 1515-1522.
  120. Forsberg, E.C., Zaboikina, T.N, Versaw, W.K., Ahn, N.G. and Bresnick, E.H. (1999) Enhancement of b-Globin locus control region-mediated transactivation by mitogen-activated protein kinases through stochastic and graded mechanisms. Mol. Cell. Biol., 19, 5565-5575.
  121. Resing, K.A., Hoofnagle, A.N. and Ahn, N.G. (1999) Modeling deuterium exchange behavior of ERK2 using pepsin mapping to probe secondary structure. J. Am. Soc. Mass Spec., 10, 685-702.
  122. Shapiro, P.S., Whalen, A.M., Tolwinski, N.S., Froelich-Ammon, S.J., Garcia, M., Osheroff, N. and Ahn, N.G. (1999) ERK activates topoisomerase IIa through a mechanism independent of phosphorylation. Mol. Cell. Biol., 19, 3551-3560.
  123. Ahn, N.G., Tolwinski, N.S., Hsiao, K. and Goueli, S.A. (1999) U0126: An inhibitor of MKK/ERK signal transduction in mammalian cells. Promega Notes, 71, 4-7.
  124. Tolwinski, N.S., Shapiro, P.S., Goueli, S. and Ahn, N.G. (1999) Nuclear localization of MAP kinase kinase-1 is promoted by serum stimulation and G2/M progression. Requirement for phosphorylation at the activation lip and signaling downstream of MKK. J. Biol. Chem., 274, 6168-6174.
  125. Resing, K.A. and Ahn, N.G. (1999) Applications of mass spectrometry to signal transduction. Prog. Biophys. Mol. Biol., 71, 501-523.
  126. Shapiro, P.S.,Vaisberg, E., Hunt, A.J., Tolwinski, N.S., Whalen, A.M., McIntosh, J.R. and Ahn, N.G. (1998) Activation of the MKK/ERK pathway during somatic cell mitosis. Direct interactions of active ERK with kinetochores and regulation of the mitotic 3F3/2 phosphoantigen. J. Cell Biol., 142, 1533-1545.
  127. Biggs, J.R., Ahn, N.G. and Kraft, A.S. (1998) Activation of the mitogen-activated protein kinase pathway in U937 leukemic cells induces phosphorylation of the amino terminus of the TATA binding protein. Cell Growth Diff., 9, 667-676.
  128. Duesbery, N.S., Webb, C., Leppla, S., Gordon, V.M., Klimpel, K.R., Copeland, T.D., Ahn, N.G., Oskarsson, M.K., Fukasawa, K., Paull, K.D. and Vande Woude, G.F. (1998) Proteolytic inactivation of MAPKK by anthrax lethal factor. Science, 280, 734-737.
  129. Veeranna, Amin, N.D, Ahn, N.G., Jaffe, H., Winters, C.A., Grant, P., and Pant, H.C. (1998) Phosphorylation of Lys-Ser-Pro (KSP) repeats in high molecular weight neurofilament protein. J. Neuroscience. 18, 4008-4021.
  130. Lewis, T.S., Shapiro, P.S. and Ahn, N.G. (1998) Signal transduction through MAP kinase cascades. Adv. Cancer Res., 74, 49-139.
  131. Shapiro, P.S. and Ahn, N.G. (1998) Feedback regulation of Raf-1 and mitogen activated protein kinase kinases 1 and 2 by MKP-1 phosphatase. J. Biol. Chem., 273, 1788-1793.
  132. Resing, K.A. and Ahn, N.G. (1998) Deuterium exchange mass spectrometry as a probe of protein kinase activation. Analysis of wild type and constitutively active mutants of MAP kinase kinase 1. Biochemistry, 37, 463-475.
  133. Frost, J.A., Steen, H., Shapiro, P., Lewis, T., Ahn, N., Shaw, P.E. and Cobb, M.H. (1997) Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins.. EMBO J., 16, 6426-6438.
  134. Font de Mora, J., Porras, A., Ahn, N. and Santos, E. (1997) Mitogen-activated protein kinase is not necessary for, but antagonizes, 3T3-L1 adipocytic differentiation. Mol. Cell. Biol., 17, 6068-6075.
  135. Resing, K.A. and Ahn, N.G. (1997) Protein phosphorylation analysis by electrospray ionization mass spectrometry. Methods Enzymology, 283, 29-44.
  136. Whalen, S.G., Marcellus, R.C., Whalen, A.M., Ahn, N.G., Ricciardi, R.P. and Branton, P.E. (1997) Phosphorylation within the transactivation domain of adenovirus E1A protein by MAP kinase regulates expression of early region 4. J. Virology, 71, 3545-3553.
  137. Whalen, A.M., Galasinski, S.C., Shapiro, P.S., Nahreini, T.S. and Ahn, N.G. (1997) Megakaryocytic differentiation induced by constitutive activation of MAP kinase kinase. Mol. Cell. Biol., 17, 1947-1958.
  138. Robinson, M.J., Cheng, M., Khokhlatchev, A., Ebert, D., Ahn, N., Guan, K.-L., Stein, B., Goldsmith, E. and Cobb, M.H. (1996) Contribution of the MAP kinase phosphorylation lip to MEK specificity. J. Biol. Chem., 271, 29734-29739.
  139. Mansour, S.J., Candia, J.M., Matsuura, J., Manning, M. and Ahn, N.G. (1996) Interdependent domains controlling the enzymatic activity of MAP kinase kinase 1. Biochemistry, 35, 15529-15536.
  140. Louie, D.F., Resing, K.A., Lewis, T.S. and Ahn, N.G. (1996) Mass spectrometric analysis of 40S ribosomal proteins from Rat-1 fibroblasts. J. Biol. Chem., 271, 28189-28198.
  141. Matten, W.T., Mansour, S.J., Copeland, T., Ahn, N.G. and Vande Woude, G.F. (1996) A positive feedback signal from MAPK to Mos during Xenopus oocyte maturation. Dev. Biol., 179, 485-492.
  142. Voyno-Yasenetskaya, T.A., Faure, M.P., Ahn, N.G., and Bourne, H.R. (1996) Ga12and Ga13regulate extracellular signal-regulated kinase and c-Jun kinase pathways by different mechanisms in COS-7 cells. J. Biol. Chem., 271, 21081-21087.
  143. Choi, T., Rulong, S., Resau, J., Fukasawa, K., Matten, W., Kuriyama, R., Mansour, S., Ahn, N. and Vande Woude, G.F. (1996) Mos/MAP kinase can induce early meiotic phenotypes in the absence of MPF: A novel system for analyzing spindle formation during meiosis I, Proc. Natl. Acad. Sci. USA, 93, 4730-4735.
  144. Mansour, S.J., Candia, J.M., Gloor, K. and Ahn, N.G. (1996) Constitutively activated MAPKK1 and MAPKK2 mediate similar transcriptional and morphological responses. Cell Growth Diff., 7, 243-250.
  145. Bokemeyer, D., Sorokin, A., Yan, M., Ahn, N.G., Templeton, D.J. and Dunn, M.J. (1996) Induction of mitogen-activated protein kinase phosphatase 1 by the stress-activated protein kinase signaling pathway but not by extracellular signal-regulated kinase in fibroblasts. J. Biol. Chem., 271, 639-642.
  146. Chepenik, K.P., Shipman-Appasamy, P., Ahn, N. and Goldowitz, D. (1995) Developmental regulation of various annexins in the embryonic palate of the mouse: Dexamethasone affects expression of annexin-1. J. Craniofacial Genetics Dev. Biol., 15, 171-181.
  147. Thorburn, J., Carlson, M., Mansour, S.J., Chien, K.R., Ahn, N.G. and Thorburn, A. (1995) Inhibition of a signaling pathway in cardiac muscle cells by active MAP kinase kinase. Mol. Biol. Cell, 11, 1479-1490.
  148. Markowitz, R.-B., Hermann, A.S., Taylor, D.F., He, L., Anthony-Cahill, S., Ahn, N.G. and Dynan, W.S. (1995) Phosphorylation of the C-terminal domain of RNA polymerase II by the extracellular-signal-regulated protein kinase, ERK2. Biochem. Biophys Res. Comm., 207, 1051-1057.
  149. Al-Alawi, N., Rose, D.W., Buckmaster, C., Ahn, N., Rapp, U., Meinkoth, J. and Feramisco, J.R. (1995) TSH-induced mitogenesis is Ras dependent but appears to bypass the Raf-dependent cytoplasmic kinase cascade. Mol. Cell Biol., 15, 1162-1168.
  150. Resing, K.A., Mansour, S.J., Hermann, A.S., Johnson, R.S., Candia, J.M., Fukasawa, K., Vande Woude, G.F. and Ahn, N.G. (1995) Determination of v-Mos catalyzed phosphorylation sites and autophosphorylation sites on MAP kinase kinase by ESI/MS. Biochemistry, 34, 2610-2620.
  151. Mansour, S.J., Matten, W.T., Hermann, A.S., Candia, J.M., Rong, S., Fukasawa, K., Vande Woude, G.F. and Ahn, N.G. (1994) Gain-of-function mutations in MAP kinase kinase promote mammalian cell transformation. Science, 265, 966-970.
  152. Mansour, S.J., Resing, K.A., Candia, J.M., Hermann, A.S., Gloor, J.W., Herskind, K.R., Wartmann, M., Davis, R.J. and Ahn, N.G. (1994) Mitogen-activated protein kinase phosphorylation of mitogen-activated protein kinase-kinase: Analysis of in vitro phosphorylation sites. J. Biochem., 116, 304-314.
  153. Posada, J., Yew, N., Ahn, N.G., Vande Woude, G.F. and Cooper, J.A. (1993) Mos stimulates MAP kinase in Xenopus oocytes and activates a MAP kinase kinase in vitro. Mol. Cell . Biol., 13, 2546-2553.
  154. Ahn, N.G. (1993) The MAP kinase cascade. Discovery of a new signal transduction pathway. Mol. Cell. Biochem., 127/128, 201-209.
  155. Genot, E.M., Meier, K.E., Liccardi, K.A., Ahn, N.G., Uittenbogaart, C.H., Wietzerbin, J., Clark, E.A. and Valentine, M.A. (1993) Phosphorylation of CD20 in cells from a hairy cell leukemia cell line. Evidence for involvement of calcium/calmodulin-dependent protein kinase II. J. Immunol., 151, 71-82.
  156. Yonemura, K., Raines, E.W., Ahn, N.G. and Narayanan, A.S. (1993) Mitogenic signalling mechanisms of human cementum-derived growth factor. J. Biol. Chem., 268, 26120-26126.
  157. Krebs, E.G., Ahn, N.G., Campbell, J.S., Graves, L.M., Seger, R. and Weiel, J.E. (1993) Regulation of protein serine/threonine kinases by tyrosine kinases. Adv. Second Messengers Phosphoprotein Res., 28, 227-236.
  158. Gause, K.C., Homma, M.K., Licciardi, K.A., Seger, R., Ahn, N.G., Peterson, M.J., Krebs, E.G. and Meier, K.E. (1993) Effects of phorbol ester in mitogen-activated protein kinase kinase activity in wild-type and phorbol ester-resistant EL4 thymoma cells. J. Biol. Chem., 268, 16124-16129.
  159. Ahn, N.G., Campbell, J.S., Seger, R., Jensen, A.L., Graves, L.M. and Krebs, E.G. (1993) Metabolic labelling of mitogen-activated protein kinase kinase in A431 cells demonstrates phosphorylation on serine and threonine residues. Proc. Natl. Acad. Sci. USA, 90, 5143-5147.
  160. Ahn, N.G., Seger, R. and Krebs, E.G. (1992) The mitogen-activated protein kinase activator. Curr. Op. Cell Biol., 4, 992-999.
  161. Seger, R., Seger, D., Lozeman, F.J., Ahn, N.G., Graves, L.M., Campbell, J.S., Ericsson, L., Harrylock, M., Jensen, A.M. and Krebs, E.G. (1992) Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases. J. Biol. Chem., 267, 25628-25631.
  162. Seger, R., Ahn, N.G., Posada, J., Munar, E.S., Jensen, A.J., Cooper, J.A., Cobb, M.H. and Krebs, E.G. (1992) Purification and characterization of mitogen-activated protein kinase activator(s) from epidermal growth factor-stimulated A431 cells. J. Biol Chem., 267, 14373-14381.
  163. Ahn, N.G., Robbins, D.J., Haycock, J.W., Seger, R., Cobb, M.H. and Krebs, E.G. (1992) Identification of an activator of the MAP kinases ERK1 and ERK2 in PC12 cells stimulated with nerve growth factor or bradykinin. J. Neurochem., 59, 147-156.
  164. Haycock, J.W., Ahn, N.G., Cobb, M.H. and Krebs, E.G. (1992). ERK1 and ERK2, two microtubule-associated protein 2 kinases, mediate the phosphorylation of tyrosine hydroxylase at serine 31 in situ. Proc. Natl. Acad. Sci. USA, 89, 2365-2369.
  165. Seger, R., Ahn, N.G., Boulton, T.G., Yancopoulos, G.D., Panayotatos, N., Radziejewska, E., Ericsson, L., Bratlien, R.L., Cobb, M.H. and Krebs, E.G. (1991). Microtubule-associated protein 2 kinases, ERK1 and ERK2, undergo autophosphorylation on both tyrosine and threonine residues: Implications for their mechanism of activation. Proc. Natl. Acad. Sci. USA, 88, 6142-6146.
  166. Ahn, N.G., Seger, R., Bratlien, R.L. and Krebs, E.G. (1991). Growth factor stimulated phosphorylation cascades: Activation of growth factor-stimulated MAP kinase. CIBA FoundationSymposia, 164, 113-131.
  167. Ahn, N.G., Seger, R., Bratlien, R.L., Diltz, C.D., Tonks, N.K. and Krebs, E.G. (1991) Multiple components in an epidermal growth factor-stimulated protein kinase cascade. In vitro activation of a MBP/MAP2 kinase. J. Biol. Chem., 256, 4220-4227.
  168. Ahn, N.G. and Krebs, E.G. (1990) Evidence for an epidermal growth factor-stimulated protein serine/threonine kinase cascade in Swiss 3T3 cells. Activation of serine peptide kinase activity by myelin basic protein kinases in vitro. J. Biol. Chem., 265, 11495-11501.
  169. Ahn, N.G., Weiel, J.E., Chan, C.P. and Krebs, E.G. (1990) Identification of multiple epidermal growth factor-stimulated protein serine/threonine kinases from Swiss 3T3 cells. J. Biol. Chem., 265, 11487-11494.
  170. Weiel, J.E., Ahn, N.G., Seger, R. and Krebs, E.G. (1990) Communication between protein tyrosine and protein serine/threonine phosphorylation. Adv. in Second Messengers and Protein Phosphorylation, Nishizuka, Y., Endo, M. and Tanaka, C., eds., Raven Press, New York, 24, pp. 182-195.
  171. Ahn, N.G. and Klinman, J.P. (1989) Nature of rate-limiting steps in a compartmentalizedenzyme system.Quantitation of dopamine transport and hydroxylation rates in resealed chromaffin granule ghosts. J. Biol. Chem., 264, 12259-12265.
  172. Ahn, N.G., Teller, D.C., Bienkowski, M.J., McMullen, B.A., Lipkin, E.W. and de Haën, C. (1988) Sedimentation equilibrium analysis of five lipocortin-related phospholipase A2inhibitors from human placenta. J. Biol. Chem., 263, 18657-18663.
  173. Ahn, N. and Klinman, J.P. (1987) Activation of dopamine b-monooxygenase by external and internal electron donors in resealed chromaffin granule ghosts. J. Biol. Chem., 262, 1485-1492.
  174. Ahn, N.G., Lipkin, E.W., Teller, D.C. and de Haën, C. (1986) Coupling between insulin binding and activation of glucose transport in rat adipocytes. Fed. Proc., 45, 1835.
  175. Ahn, N. and Klinman, J.P. (1983) Mechanism of modulation of dopamine b-monooxygenase by pH and fumarate as deduced from initial rate and primary deuterium isotope effect studies. Biochemistry, 22, 3096-3106.