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June 2024

ESC and iPSC

1. Capturing Totipotency in Human Cells through Spliceosomal Repression, , (Cell)
2. Applications, Challenges, and Prospects of Induced Pluripotent Stem Cells for Vascular Disease, , (Molecules and Cells)
3. X-chromosome Inactivation in Human iPSCs Provides Insight into X-Regulated Gene Expression in Autosomes, , (Genome Biology)
4. Advances and Challenges in Modeling Inherited Peripheral Neuropathies Using iPSCs, , (Experimental & Molecular Medicine)
5. The Relationship between Nanoscale Genome Organization and Gene Expression in Mouse Embryonic Stem Cells during Pluripotency Transition, , (Nucleic Acids Research)
6. Molecular Mechanism of BMP Signal Control by Twisted Gastrulation, , (Nature Communications)

Neural

1. Developmental Origin of Oligodendrocytes Determines Their Function in the Adult Brain, , (Nature Neuroscience)
2. Protein Translation Rate Determines Neocortical Neuron Fate, , (Nature Communications)
3. The Necroptosis Cell Death Pathway Drives Neurodegeneration in Alzheimer’s Disease, , (Acta Neuropathologica)
4. Spinal Inhibitory Neurons Degenerate before Motor Neurons and Excitatory Neurons in a Mouse Model of ALS, , (Science Advances)
5. Multiscale Engineering of Brain Organoids for Disease Modeling, , (Advanced Drug Delivery Reviews)
6. Myelin Plasticity in the Ventral Tegmental Area Is Required for Opioid Reward, , (Nature)
7. Neuronal Activity-Driven O-GlcNAcylation Promotes Mitochondrial Plasticity, , (Developmental Cell)

Cell Therapy

1. Transient Growth Factor Expression via mRNA in Lipid Nanoparticles Promotes Hepatocyte Cell Therapy in Mice, , (Nature Communications)
2. Heterologous Survey of 130 DNA Transposons in Human Cells Highlights Their Functional Divergence and Expands the Genome Engineering Toolbox, , (Cell)
3. Engineering Viral Vectors for Acoustically Targeted Gene Delivery, , (Nature Communications)
4. Bioactive-Material-Programmed CAR-T Cell Living Drug for Augmented Immunotherapy against Tumors, , (Cell Reports Physical Science)
5. Regenerative Medicine Act Passes Final Reading at Legislature, , (Focus Taiwan)

Organoid

1. Next-Generation Modeling of Cancer Using Organoids, , (Cold Spring Harbor Perspectives In Medicine)
2. A 3D Bioprinted Cortical Organoid Platform for Modeling Human Brain Development, , (Advanced Healthcare Materials)
3. Mice Hepatic Organoids for Modeling Nonalcoholic Fatty Liver Disease and Drug Response,, (Stem Cells and Development)
4. A Microfluidic Chip-Based Automated System for Whole-Course Monitoring the Drug Responses of Organoids, , (Analytical Chemistry)
5. A Novel Thin Plate Spline Methodology to Model Tissue Surfaces and Quantify Tumor Cell Invasion in Organ-on-Chip Models, , (Slas Discovery)
6. First-in-Kind Protocol for Creating Miniature Artificial Brains, , (TECH Explorist)
7. iPSC-Derived Hindbrain Organoids to Evaluate Escitalopram Oxalate Treatment Responses Targeting Neuropsychiatric Symptoms in Alzheimer’s Disease, , (Molecular Psychiatry)
8. Human Amniotic Mesenchymal Stem Cell-Islet Organoids Enhance the Efficiency of Islet Engraftment in a Mouse Diabetes Model, , (Life Sciences)

May 2024

ESC and IPSC 

• Single-Cell 3D Genome Structure Reveals Distinct Human Pluripotent States  (Genome Biology)
• The First Two Blastomeres Contribute Unequally to the Human Embryo  (Cell)
• Enhancing Genome Editing in hPSCs through Dual Inhibition of DNA Damage Response and Repair Pathways  (Nature Communications)
• Quantitative Proteomics Reveals the Dynamic Proteome Landscape of Zebrafish Embryos during the Maternal-to-Zygotic Transition  (iScience)
• Scientists Are Trying to Get Cows Pregnant with Synthetic Embryos  (MIT Technology Review)
• Forward Programming Human Pluripotent Stem Cells into Microglia  (Trends in Cell Biology)
• Cabinet Approves Two Draft Bills on Regenerative Medicine  (Overseas Community Affairs Council, Republic of China)
• 3D Reconstruction of a Gastrulating Human Embryo (Cell)

Neural 

• The Vascular Contribution of Apolipoprotein E to Alzheimer’s Disease  (Brain)
• The Role of Cellular Senescence in Neurodegenerative Diseases  (Archives Of Toxicology)
• Itaconate Protects Ferroptotic Neurons by Alkylating GPx4 Post Stroke  (Cell Death & Differentiation)
• Actomyosin-II Protects Axons from Degeneration Induced by Mild Mechanical Stress  (Journal Of Cell Biology
• Cell Adhesion Molecule Signaling at the Synapse: Beyond the Scaffold  (Cold Spring Harbor Perspectives In Biology)
• Autism Patient-Derived SHANK2BY29X Mutation Affects the Development of ALDH1A1 Negative Dopamine Neuron  (Molecular Psychiatry)
• New Perspective on Sustained Antidepressant Effect: Focus on Neurexins Regulating Synaptic Plasticity  (Cell Death Discovery)
• Origin, Identity, and Function of Terminal Schwann Cells  (Trends In Neurosciences)

Cell Therapy 

• Global Effort Aims to Protect Health and Safety of Human ‘Guinea Pigs’ in Drug Trials  (Science Insider)
• RNA Aggregates Harness the Danger Response for Potent Cancer Immunotherapy  (Cell)
• Single-Cell Transcriptome Landscape and Cell Fate Decoding in Human Brain  Organoids after Transplantation  (Advanced Science)
• Promoting Alzheimer’s Disease Research and Therapy with Stem Cell Technology  (Stem Cell Research & Therapy)
• Mechanism of Action, Potency and Efficacy: Considerations for Cell Therapies  (Journal Of Translational Medicine)
• Recent Trends in 3D Bioprinting Technology for Skeletal Muscle Regeneration  (Acta Biomaterialia)
• GLUT1 Overexpression Enhances CAR T Cell Metabolic Fitness and Anti-Tumor Efficacy  (Molecular Therapy)
• First Fetus-to-Fetus Transplant Demonstrated in Rats (Nature News)

Organoid 

• Pannexin1 Channel-Mediated Inflammation in Acute Ischemic Stroke  (Aging and Disease)
• FinalSpark Launches the First Remote Research Platform Using Human Neurons for Biocomputing  (FinalSpark (Businesswire))
• Establishment of Human Hematopoietic Organoids for Evaluation of Hematopoietic Injury and Regeneration Effect  (Stem Cell Research & Therapy)
• First Model of the Brain’s Information Highways Developed  (Informationsdienst Wissenschaft) 
• Cerebral Organoids Display Dynamic Clonal Growth and Tunable Tissue Replenishment  (Nature Cell Biology)
• High-Fat Diet Enhances Cell Proliferation and Compromises Intestinal Permeability in a Translational Canine Intestinal Organoid Model  (BMC Molecular And Cell Biology)
• Sebaceous Gland Organoid Engineering  (Burns & Trauma)
• Induced Pluripotent Stem Cells (iPSCs): Molecular Mechanisms of Induction and Applications  (Signal Transduction And Targeted Therapy)

April 2024

ESC and IPSC 

• A High Efficiency Precision Genome Editing Method with CRISPR in iPSCs  (Scientific Reports)
• Development and Application of Haploid Embryonic Stem Cells  (Stem Cell Research & Therapy)
• Human Embryonic Genetic Mosaicism and Its Effects on Development and Disease  (Nature Genetics)
• Annelid Adult Cell Type Diversity and Their Pluripotent Cellular Origins  (Nature Communications)
• Reconstructing Axial Progenitor Field Dynamics in Mouse Stem Cell-Derived Embryoids  (Developmental Cell)
• Crispr-Based Editing of Human Pluripotent Stem Cells for Disease Modeling  (Stem Cell Reviews and Reports)
• Induced Pluripotent Stem Cells in Cartilage Tissue Engineering: A Literature Review  (Bioscience Reports)
• Scientists Made a Six-Legged Mouse Embryo — Here’s Why  (Nature)

Neural 

• Origin, Identity, and Function of Terminal Schwann Cells  (Trends In Neurosciences)
• New Research Suggests Cerebellum May Play Important Role in Autism   (UC Davis Health)
• Neural Tracing Protein-Functionalized Nanoparticles Capable of Fast Retrograde Axonal Transport in Live Neurons  (Small)
• An Improved Method for Generating Human Spinal Cord Neural Stem Cells  (Experimental Neurology)
• Neurofilaments as Biomarkers in Neurological Disorders — towards Clinical Application  (Nature Reviews Neurology)
• Autophagy and Exosomes; Inter-Connected Maestros in Alzheimer’s Disease  (Inflammopharmacology)
• Immunological Aspects of Central Neurodegeneration (Cell Discovery)
• The Endotoxin Hypothesis of Alzheimer’s Disease (Molecular Neurodegeneration)

Cell Therapy 

• First Fetus-to-Fetus Transplant Demonstrated in Rats (Nature News)
• Cell Culture on Suspended Fiber for Tissue Regeneration: A Review  (International Journal Of Biological Macromolecules)
• Expression and Processing of Mature Human Frataxin after Gene Therapy in Mice  (Scientific Reports)
• This Startup Wants To Be OpenAI Of Stem Cell Therapy, Targets $250B Market  (Forbes)
• Mitochondrial DNA as a Target for Analyzing the Biodistribution of Cell Therapy Products  (Scientific Reports)
• The Dual Role of Mesenchymal Stem Cells in Apoptosis Regulation  (Cell Death & Disease)
• Xcell Biosciences Strengthens Cell and Gene Therapy Collaboration with Labcorp  (Xcell Biosciences, Inc. (BusinessWire))

Organoid 

• Replacing Animal Testing With Stem Cell-Organoids: Advantages and Limitations  (Stem Cell Reviews And Reports)
• Antisense Oligonucleotide Therapeutic Approach for Timothy Syndrome  (Nature)
• Generation of Human Cerebral Organoids with a Structured Outer Subventricular Zone  (Cell Reports)
• Advancing Organoid Engineering for Tissue Regeneration and Biofunctional Reconstruction  (Biomaterials Research)
• Uncharted Territory: Ethical Questions Cloud Fetal Brain Organoid Research  (Brain Tomorrow)
• Promising Preclinical Models for Lung Cancer Research—Lung Cancer Organoids: A Narrative Review  (Translational Lung Cancer Research)
• Complex Activity and Short-Term Plasticity of Human Cerebral Organoids Reciprocally Connected with Axons  (Nature Communications)
• Generation of Human Cerebral Organoids with a Structured Outer Subventricular Zone  (Cell Reports)

March 2024

ESC and IPSC 

• Diverting the Food-Freezing Technology Improves the Cryopreservation Efficiency of Induced Pluripotent Stem Cells and Derived Neurospheres  (Regenerative Therapy)
• Stem Cell Models of Inherited Arrhythmias  (Nature Cardiovascular Research)
• iPSC-Derived Models for Anorexia Nervosa Research (Trends in Molecular Medicine)
• Fetal Tissue Research Gains in Importance as Roadblocks Multiply  (STAT News)
• Crosstalk between Signaling Pathways and Energy Metabolism in Pluripotency  (International Journal Of Stem Cells)
• Will These Reprogrammed Elephant Cells Ever Make a Mammoth?  (Nature)
• Embryonic Stem Cell Transplant Showing Safety in 12 Patients  (Parkinson’s News Today)

Neural 

• Biofilm Exopolysaccharides Alter Sensory-Neuron-Mediated Sickness during Lung Infection  (Cell)
• The Dynamics of Notch Signaling in the Neuron-Glia Switch: A Balancing Act  (Journal Of Neurophysiology)
• Genetically Engineered Marmosets Promise Insight into Early Stages of Parkinson’s  (Science)
• Contrasting Somatic Mutation Patterns in Aging Human Neurons and Oligodendrocytes  (Cell)
• Updates on Mouse Models of Alzheimer’s Disease (Molecular Neurodegeneration)
• Neuropathogenesis-on-Chips for Neurodegenerative Diseases  (Nature Communications)
• U of T Startup Targets Harmful Side Effect of Cancer Treatment  (University of Toronto)
• Computer scientist Wins NSF CAREER Award to Advance Alzheimer’s Research Using AI  (Wake Forest University)
• Neuronal Dynamics Direct Cerebrospinal Fluid Perfusion and Brain Clearance  (Nature)

Cell Therapy 

• Nanomaterials Boost CAR-T Therapy for Solid Tumors (Advanced Healthcare Materials)
• A Humanized Mouse Model for Adeno-Associated Viral Gene Therapy  (Nature Communications)
• Why Is The FDA Concerned Å·ÃÀ¿Ú±¬ÊÓƵ Secondary Cancers After CAR T Cells?  (Forbes)
• Synthetic Receptor Scaffolds Significantly Affect the Efficiency of Cell Fate Signals  (Scientific Reports)
• Targeted Nonviral Delivery of Genome Editors In Vivo (Proceedings Of The National Academy Of Sciences Of The United States Of America)
• Emerging Strategies for Nanomedicine in Autoimmunity  (Advanced Drug Delivery Reviews)
• Scripps Research Scientists Honored With Prestigious CZI Awards to Address Diseases Tied to Aging  (Scripps Research)

Organoid 

• Past and Future of Alveolar Organoids for Lung Regenerative Medicine  (Stem Cells)
• Advances and Applications of Cancer Organoids in Drug Screening and Personalized Medicine  (Stem Cell Reviews And Reports)
• Establishment of Patient-Derived Organoids for Guiding Personalized Therapies in Breast Cancer Patients  (International Journal Of Cancer)
• Organ-on-Chip Models for Infectious Disease Research  (Nature Microbiology)
• Cholangiocyte Organoids to Study Drug-Induced Injury (BMC)
• Bioengineering Toolkits for Potentiating Organoid Therapeutics  (Advanced Drug Delivery Reviews)
• Cellular Reprogramming as a Tool to Model Human Aging in a Dish  (Nature Communications)
• Vascularized Organoid-on-a-Chip: Design, Imaging, and Analysis  (Angiogenesis)

February 2024

ESC and IPSC 

• Multiomics Evaluation of Human iPSCs and iPSC-Derived Neurons  (Journal Of Proteome Research)
• Cellular Reprogramming as a Tool to Model Human Aging in a Dish   (Nature Communications)
• Epigenetic Reprogramming in the Transition from Pluripotency to Totipotency  (Journal of Cell Physiology)
• A Single-Cell Time-Lapse of Mouse Prenatal Development From Gastrula to Birth  (Nature)
• Pluripotent Stem Cell-Based Cardiac Regenerative Therapy for Heart Failure  (Journal Of Molecular And Cellular Cardiology)
• China Conducts First Nationwide Review of Retractions and Research Misconduct  (Nature News)
• Induced-Pluripotent Stem Cells and Neuroproteomics as Tools for Studying Neurodegeneration  (Academic Radiology)
• Improving Stem Cell Research  (Harvard University)

Neural 

• Multisensory Gamma Stimulation Promotes Glymphatic Clearance of Amyloid  (Nature)
• Neuralink Brain Chip: Advance Sparks Safety and Secrecy Concerns  (Nature)
• GFAP-Isoforms in the Nervous System: Understanding the Need for Diversity  (Current Opinion in Cell Biology)
• Dissecting the Spatiotemporal Diversity of Adult Neural Stem Cells  (Molecular Systems Biology)
• New Rabies Viral Resources for Multi-Scale Neural Circuit Mapping  (Molecular Psychiatry)
• Identification of Direct Connections between the Dura and the Brain  (Nature)
• 3D Printer Creates Brain Tissue That Acts like the Real Thing  (Science)
• Mitochondrial Stress: A Key Role of Neuroinflammation in Stroke  (Journal of Neuroinflammation)

Cell Therapy 

• Gene Therapy in Glioblastoma Multiforme: Can It Be a Role Changer?  (Heliyon)
• Inibitory CARs Fail to Protect From Immediate T Cell Cytotoxicity  (Molecular Therapy)
• In ‘Major Milestone,’ FDA Approves First Cell Therapy for Solid Tumors  (STAT News)
• Gene Therapy Allows a Deaf Child to Hear for the First Time  (Nature Italy)
• Host Brain Environmental Influences on Transplanted Medial Ganglionic Eminence Progenitors  (Scientific Reports)
• Naturally Occurring T Cell Mutations Enhance Engineered T Cell Therapies  (Fractals-Complex Geometry Patterns And Scaling In Nature And Society)
• Roles of Exosomes in Immunotherapy for Solid Cancers  (Cell Death & Disease)

Organoid 

• The Benefits of Stem Cell Biology and Tissue Engineering in Low-Earth Orbit  (Stem Cells And Development)
• Comparing Stem Cells, Transdifferentiation, and Brain Organoids as Tools for Psychiatric Research  (Translational Psychiatry)
• Advanced Lung Organoids for Respiratory System and Pulmonary Disease Modeling  (Journal of Tissue Engineering)
• A Growth Factor-Reduced Culture System for Colorectal Cancer Organoids  (Cancer Letters)
• Chromatin Remodeling in Patient-Derived Colorectal Cancer Models  (Advanced Science)
• Shaping the Neurovascular Unit Exploiting Human Brain Organoids  (Molecular Neurobiology)
• Live Organoid Cyclic Imaging  (Advanced Science)
• Characterizing Human Astrocyte Calcium Signaling in a Cerebral Organoid  (Biophysical Journal)

January 2024

ESC &iPSC

• Hallmarks of Stemness in Mammalian Tissues https://www.stemcellsciencenews.com/newsletter/219117/ (Cell Stem Cell)
• FOXO1-Mediated Lipid Metabolism Maintains Mammalian Embryos in Dormancy https://www.stemcellsciencenews.com/newsletter/219186/ (Nature Cell Biology)
• DNA Methylation Restricts Coordinated Germline and Neural Fates in Embryonic Stem Cell Differentiation https://www.stemcellsciencenews.com/newsletter/219185/ (Nature Structural & Molecular Biology)
• XIST Directly Regulates X-Linked and Autosomal Genes in Naive Human Pluripotent Cells https://www.stemcellsciencenews.com/newsletter/219250/ (Cell)
• Mitotic Bookmarking Redundancy by Nuclear Receptors in Pluripotent Cells https://www.stemcellsciencenews.com/newsletter/219390/ (Nature Structural & Molecular Biology)
• ROR2 Expression Predicts Human-Induced Pluripotent Stem Cell Differentiation into Neural Stem/Progenitor Cells and GרAergic Neurons https://www.stemcellsciencenews.com/newsletter/219597/ (Scientific Reports)
• Generation of Three Isogenic Human Induced Pluripotent Stem Cell Lines from Normal Neonate Skin Fibroblasts https://www.stemcellsciencenews.com/newsletter/219595/ (Stem Cell Research)
• Incomplete Reprogramming of DNA Replication Timing in Induced Pluripotent Stem Cells https://www.stemcellsciencenews.com/newsletter/219593/ (Cell Reports)
• Cloned Rhesus Monkey Lives to Adulthood for First Time https://www.stemcellsciencenews.com/newsletter/219801/ (Nature News)
• Lineage Regulators TFAP2C and NR5A2 Function as Bipotency Activators in Totipotent Embryos https://www.stemcellsciencenews.com/newsletter/219996/ (Nature Structural & Molecular Biology)
• ZFP281 Controls Transcriptional and Epigenetic Changes Promoting Mouse Pluripotent State Transitions via DNMT3 and TET1 https://www.stemcellsciencenews.com/newsletter/220028/ (Developmental Cell)
• Telomere Dynamics in Human Pluripotent Stem Cells https://www.stemcellsciencenews.com/newsletter/220209/ (Cell Cycle)
• The Impact of Induced Pluripotent Stem Cells in Animal Conservation https://www.stemcellsciencenews.com/newsletter/220205/ (Veterinary Research Communications)

Neural

• SpaceX Returns Vital Life Science Research Sponsored by the ISS National Lab https://www.stemcellsciencenews.com/newsletter/219008/ (ISS National Lab)
• Shigella Virulence Protein VirG Is a Broadly Protective Antigen and Vaccine Candidate https://www.stemcellsciencenews.com/newsletter/219023/ (NPJ Vaccines)
• Combined Small-Molecule Treatment Accelerates Maturation of Human Pluripotent Stem Cell-Derived Neurons https://www.stemcellsciencenews.com/newsletter/219022/ (Nature Biotechnology)
• Human Cerebellar Organoids with Functional Purkinje Cells https://www.stemcellsciencenews.com/newsletter/219114/ (Cell Stem Cell)
• The Long-Term Effects of Heated Tobacco Product Exposure on the Central Nervous System in a Mouse Model of Prodromal Alzheimer’s Disease https://www.stemcellsciencenews.com/newsletter/219054/ (Scientific Reports)
•  Synaptic-Like Transmission between Neural Axons and Arteriolar Smooth Muscle Cells Drives Cerebral Neurovascular Coupling https://www.stemcellsciencenews.com/newsletter/219229/ (Nature Neuroscience)
• Yap/Taz Activity Is Associated with Increased Expression of Phosphoglycerate Dehydrogenase That Supports Myoblast Proliferation https://www.stemcellsciencenews.com/newsletter/219228/ (Cell And Tissue Research)
• Predicting Myosin Heavy Chain Isoform from Post-Dissection Fiber Length in Human Skeletal Muscle Fibers https://www.stemcellsciencenews.com/newsletter/219225/ (American Journal Of Physiology-Cell Physiology)
• Microglia Enhance Post-Anesthesia Neuronal Activity by Shielding Inhibitory Synapses https://www.stemcellsciencenews.com/newsletter/219271/ (Nature Neuroscience)
• Long and Short-Term Effect of mTOR Regulation on Cerebral Organoid Growth and Differentiations https://www.stemcellsciencenews.com/newsletter/219266/ (Tissue Engineering And Regenerative Medicine)
• Neocortical Neurogenesis in Development and Evolution—Human-Specific Features https://www.stemcellsciencenews.com/newsletter/219377/ (Journal of Comparative Neurology)
• Apically Localized PANX1 Impacts Neuroepithelial Expansion in Human Cerebral Organoids https://www.stemcellsciencenews.com/newsletter/219468/ (Cell Death Discovery)
• First Brain Organoids Grown from Fetal Tissue Offer Window on Development https://www.stemcellsciencenews.com/newsletter/219523/ (Science)
• Molecular Profiling of Human Substantia Nigra Identifies Diverse Neuron Types Associated with Vulnerability in Parkinson’s Disease https://www.stemcellsciencenews.com/newsletter/219671/ (Science Advances)
• IFITM3 Promotes Glioblastoma Stem Cell-Mediated Angiogenesis via Regulating JAK/STAT3/bFGF Signaling Pathway https://www.stemcellsciencenews.com/newsletter/219772/ (Cell Death & Disease)
• Neural Stem Cell Homeostasis Is Affected in Cortical Organoids Carrying a Mutation in Angiogenin https://www.stemcellsciencenews.com/newsletter/219773/ (Journal Of Pathology)
• The Role of IL-6 in Neurodegenerative Disorders https://www.stemcellsciencenews.com/newsletter/219840/ (Neurochemical Research)
• TREM2 Variants That Cause Early Dementia and Increase Alzheimer’s Disease Risk Affect Gene Splicing https://www.stemcellsciencenews.com/newsletter/219838/ (Brain)
• DNA Methylation-Mediated Repression of microRNA-410 Promotes the Growth of Human Glioma Cells and Triggers Cell Apoptosis Through Its Interaction with STAT3 https://www.stemcellsciencenews.com/newsletter/219919/ (Scientific Reports)
• SARS-CoV-2 Infection Causes Dopaminergic Neuron Senescence https://www.stemcellsciencenews.com/newsletter/220096/ (Cell Stem Cell)
• Modeling the Neuroimmune System in Alzheimer’s and Parkinson’s Diseases https://www.stemcellsciencenews.com/newsletter/220168/ (Journal of Neuroinflammation)

Organoid

• Vascularized Liver-on-a-Chip Model to Investigate Nicotine-Induced Dysfunction https://www.stemcellsciencenews.com/newsletter/219017/ (Biomicrofluidics)
• Human Apical-Out Nasal Organoids Reveal an Essential Role of Matrix Metalloproteinases in Airway Epithelial Differentiation https://www.stemcellsciencenews.com/newsletter/219027/ (Nature Communications)
• High-Throughput Deconvolution of 3D Organoid Dynamics at Cellular Resolution for Cancer Pharmacology with Cellos https://www.stemcellsciencenews.com/newsletter/219116/ (Nature Communications)
• Analysis of Off-Tumor Toxicities of T Cell-Engaging Bispecific Antibodies via Donor-Matched Intestinal Organoids and Tumoroids https://www.stemcellsciencenews.com/newsletter/219115/ (Nature Biomedical Engineering)
• Kidney Organoid Models Reveal Cilium-Autophagy Metabolic Axis as a Therapeutic Target for PKD Both In Vitro and In Vivo https://www.stemcellsciencenews.com/newsletter/219113/ (Cell Stem Cell)
• Spatiotemporal Modulation of Growth Factors Directs the Generation of Multilineage Mouse Embryonic Stem Cell-Derived Mammary Organoids https://www.stemcellsciencenews.com/newsletter/219112/ (Developmental Cell)
• EGFR-Activated Myofibroblasts Promote Metastasis of Pancreatic Cancer https://www.stemcellsciencenews.com/newsletter/219111/ (Cancer Cell)
• Predictive Metabolomic Signatures for Safety Assessment of Three Plastic Nanoparticles Using Intestinal Organoids https://www.stemcellsciencenews.com/newsletter/219187/ (Science Of The Total Environment)
• Human Fetal Brain Self-Organizes Into Long-Term Expanding Organoids https://www.stemcellsciencenews.com/newsletter/219253/ (Cell)
• Long and Short-Term Effect of mTOR Regulation on Cerebral Organoid Growth and Differentiations https://www.stemcellsciencenews.com/newsletter/219266/ (Tissue Engineering And Regenerative Medicine)
• A Disulfidptosis-Related lncRNAs Signature in Hepatocellular Carcinoma: Prognostic Prediction, Tumor Immune Microenvironment and Drug Susceptibility https://www.stemcellsciencenews.com/newsletter/219320/ (Scientific Reports)
• Human Conjunctiva Organoids To Study Ocular Surface Homeostasis and Disease https://www.stemcellsciencenews.com/newsletter/219475/ (Cell Stem Cell)
• Stem Cell Investigations to Improve Cancer Treatment Among Payloads Flying on Axiom Space’s Third Private Astronaut Mission https://www.stemcellsciencenews.com/newsletter/219474/ (ISS National Laboratory)
• Organoids Derived From Patients Provide a New Opportunity for Research and Individualized Treatment of Malignant Peritoneal Mesothelioma https://www.stemcellsciencenews.com/newsletter/219471/ (Molecular Cancer)
• In Vitro Models for Investigating Intestinal Host-Pathogen Interactions https://www.stemcellsciencenews.com/newsletter/219472/ (Advanced Science)
• Uniform Cerebral Organoid Culture on a Pillar Plate by Simple and Reproducible Spheroid Transfer From an Ultralow Attachment Well Plate https://www.stemcellsciencenews.com/newsletter/219470/ (Biofabrication)
• Precancerous Nature of Intestinal Metaplasia With Increased Chance of Conversion and Accelerated DNA Methylation https://www.stemcellsciencenews.com/newsletter/219469/ (Gut)
• Micro instrumentation for Brain Organoids https://www.stemcellsciencenews.com/newsletter/219647/ (Advanced Healthcare Materials)
• Bioassembly of Multicellular Spheroids to Mimic Complex Tissue Structure Using Surface-Modified Magnetized Nanofibers https://www.stemcellsciencenews.com/newsletter/219689/ (Biofabrication)
• Gelatin-Based Hybrid Hydrogels as Matrices for Organoid Culture https://www.stemcellsciencenews.com/newsletter/219889/ (Biomacromolecules)
• Establishment of Tumor Microenvironment-Å·ÃÀ¿Ú±¬ÊÓƵ Organoid Model from Patients with Intracranial Meningioma https://www.stemcellsciencenews.com/newsletter/220164/ (Cancer Cell International)

December 2023

Neural News

• The Neurobiology of SARS-CoV-2 Infection (Nature Reviews Neuroscience)
• Patient- and Xenograft-Derived Organoids Recapitulate Pediatric Brain Tumor Features and Patient Treatments (EMBO Molecular Medicine)
• Targeting Synapse Function and Loss for Treatment of Neurodegenerative Diseases (Nature Reviews Drug Discovery)
• White Matter Injury across Neurodegenerative Disease (Trends In Neurosciences)
• Human-Specific Features and Developmental Dynamics of the Brain N-glycome (Science Advances)
• Efficient Generation of Brain Organoids Using Magnetized Gold Nanoparticles (Scientific Reports)
• Simvastatin Differentially Modulates Glial Functions in Cultured Cortical and Hypothalamic Astrocytes Derived from Interferon α/β Receptor Knockout Mice (Neurochemical Research)
• Econazole Selectively Induces Cell Death in NF1-Homozygous Mutant Tumor Cells (Cell Reports Medicine)

Organoid News

• Patient- and Xenograft-Derived Organoids Recapitulate Pediatric Brain Tumor Features and Patient Treatments (EMBO Molecular Medicine)
• A Rapid and Stable Spontaneous Reprogramming System of Spermatogonial Stem Cells to Pluripotent State (Cell & Bioscience)
• Efficient Generation of Brain Organoids Using Magnetized Gold Nanoparticles (Scientific Reports)
• Applications of Lung Cancer Organoids in Precision Medicine: From Bench to Bedside (Cell Communication and Signaling)
• The Impact of Extracellular Matrix on the Precision Medicine Utility of Pancreatic Cancer Patient-Derived Organoids (JCI Insight)
• In Vitro Modeling of the Human Dopaminergic System Using Spatially Arranged Ventral Midbrain–Striatum–Cortex Assembloids (Nature Methods)
• Single-Organoid Analysis Reveals Clinically Relevant Treatment-Resistant and Invasive Subclones in Pancreatic Cancer (NPJ Precision Oncology)
• 3D Hepatic Organoid Production from Human Pluripotent Stem Cells (Differentiation)
• Single-Cell Transcriptome Profiling of Primary Tumors and Paired Organoids of Pancreatobiliary Cancer (Cancer Letters)
• Adult Dental Epithelial Stem Cell-Derived Organoids Deposit Hydroxylapatite Biomineral (International Journal of Oral Science)
• Stress-Free Cell Aggregation by Using the CEPT Cocktail Enhances Embryoid Body and Organoid Fitness (Biofabrication)

ESC & iPSC

• The Circadian Regulator PER1 Promotes Cell Reprogramming by Inhibiting Inflammatory Signaling From Macrophages (PLOS Biology)
• NAT10-Mediated ac4C Modification Promotes Ectoderm Differentiation of Human Embryonic Stem Cells via Acetylating NR2F1 mRNA (Cell Proliferation)
• Hypoblast From Human Pluripotent Stem Cells Regulates Epiblast Development (Nature)
• Synthetic Genetic Circuits To Uncover the OCT4 Trajectories of Successful Reprogramming of Human Fibroblasts (Science Advances)
• A Human Embryonic Limb Cell Atlas Resolved in Space and Time (Nature)
• Loss of Cohesin Regulator PDS5A Reveals Repressive Role of Polycomb Loops (Nature Communications)
• Evaluating the In Vitro Developmental Toxicity Potency of a Series of Petroleum Substance Extracts Using New Approach Methodologies (NAMs) (Archives Of Toxicology)
• Applications of Plant-made Fibroblast Growth Factor for Human Pluripotent Stem Cells (Stem Cells And Development)
• Metabolic Regulatory Network Kinetic Modeling with Multiple Isotopic Tracers for iPSCs (Biotechnology And Bioengineering)
• Utility of Human Induced Pluripotent Stem Cell-Derived Small Intestinal Epithelial Cells for Pharmacokinetic, Toxicological, and Immunological Studies (Biochemical And Biophysical Research Communications)
• A Patterned Human Primitive Heart Organoid Model Generated by Pluripotent Stem Cell Self-Organization (Nature Communications)
• In Vitro Production of Naked Mole-Rats’ Blastocysts From Non-Breeding Females Using In Vitro Maturation and Intracytoplasmic Sperm Injection (Scientific Reports)

November 2023

ESC & iPSC News

• Metabolic Plasticity Sustains the Robustness of Caenorhabditis elegans Embryogenesis (EMBO Reports) https://www.stemcellsciencenews.com/newsletter/216547/
• The PERK Branch of the Unfolded Protein Response Safeguards Protein Homeostasis and Mesendoderm Specification of Human Pluripotent Stem Cells (Advanced Science) https://www.stemcellsciencenews.com/newsletter/216809/
• A Novel Perfusion Bioreactor Promotes the Expansion of Pluripotent Stem Cells in a 3D-Bioprinted Tissue Chamber (Biofabrication) https://www.stemcellsciencenews.com/newsletter/216803/
• NR5A2 Connects Zygotic Genome Activation to the First Lineage Segregation in Totipotent Embryo(Cell Research) https://www.stemcellsciencenews.com/newsletter/217008/
• Generation of Glucocorticoid-Producing Cells Derived from Human Pluripotent Stem Cells (Cell Reports Methods) https://www.stemcellsciencenews.com/newsletter/217006/
• Mammalian Oocytes Store Proteins for the Early Embryo on Cytoplasmic Lattices (Cell) https://www.stemcellsciencenews.com/newsletter/217003/
• Generation, Characterization, and Differentiation of Induced Pluripotent Stem-Like Cells in the Domestic Cat (Reproduction & Development) https://www.stemcellsciencenews.com/newsletter/217088/
• Small Molecule-Mediated Reprogramming of Xenopus Blastula Stem Cells to a Neural Crest State (Developmental Biology) https://www.stemcellsciencenews.com/newsletter/217085/
• This Hybrid Baby Monkey Is Made of Cells from Two Embryos (Nature) https://www.stemcellsciencenews.com/newsletter/217226/
• Single-Cell, Whole-Embryo Phenotyping of Mammalian Developmental Disorders (Nature) https://www.stemcellsciencenews.com/newsletter/217353/
• Generation of Induced Pluripotent Stem Cell Lines IRMBi003-A and IRMBi003-B from a Healthy Donor to Model Alzheimer’s Disease (Stem Cell Research) https://www.stemcellsciencenews.com/newsletter/217745/
• Generation of an NCS1 Gene Knockout Human Induced Pluripotent Stem Cell Line Using CRISPR/Cas9 (Stem Cell Research) https://www.stemcellsciencenews.com/newsletter/217746/
• Use of 2D Minilungs from Human Embryonic Stem Cells to Study the Interaction of Cryptococcus neoformans with the Respiratory Tract (Microbes And Infection) https://www.stemcellsciencenews.com/newsletter/218128/
• Functional Engineering of Human iPSC-Derived Parasympathetic Neurons Enhances Responsiveness to Gastrointestinal Hormones (FEBS Open Bio) https://www.stemcellsciencenews.com/newsletter/218127/
• Generation of Induced Pluripotent Stem Cell Line (RCMGi012-a) From Fibroblasts of Patient With Mucopolysaccharidosis Type VI (Stem Cell Research) https://www.stemcellsciencenews.com/newsletter/218126/

Cell Therapy News

• CAR T Cell Design-Dependent Remodeling of the Brain Tumor-Immune Microenvironment Modulates Tumor-Associated Macrophages and Anti-Glioma Activity (Cancer Research Communications) https://www.stemcellsciencenews.com/newsletter/217570/
• Implications of High Tumor Burden on Chimeric Antigen Receptor T Cell Immunotherapy (JAMA Oncology) https://www.stemcellsciencenews.com/newsletter/217588/
• Anti-TACI Single and Dual-Targeting CAR T Cells Overcome BCMA Antigen Loss in Multiple Myeloma (Nature Communications) https://www.stemcellsciencenews.com/newsletter/217569/
• CAR T Cells for Treating Autoimmune Diseases (RMD Open) https://www.stemcellsciencenews.com/newsletter/218023/
• Cell-Based Therapy by Autologous Bone Marrow-Derived Mononuclear Cells for Bone Augmentation of Plate-Stabilized Proximal Humeral Fractures – a Multicentric, Randomized, Open Phase IIa Study (Stem Cells Translational Medicine) https://www.stemcellsciencenews.com/newsletter/218019/
• Genetic Retargeting of E3 Ligases to Enhance CAR T Cell Therapy (Cell Chemical Biology) https://www.stemcellsciencenews.com/newsletter/218018/
• An In Vitro Model of the Macrophage-Endothelial Interface to Characterize CAR T-cell Induced Cytokine Storm (Scientific Reports) https://www.stemcellsciencenews.com/newsletter/216840/
• Smart Nanoparticles for Cancer Therapy (Signal Transduction and Targeted Therapy) https://www.stemcellsciencenews.com/newsletter/216992/
• AT7867 Promotes Pancreatic Progenitor Differentiation of Human iPSCs (Stem Cell Reports) https://www.stemcellsciencenews.com/newsletter/216989/
• Transplanting Old Organs Promotes Senescence in Young Recipients (American Journal Of Transplantation) https://www.stemcellsciencenews.com/newsletter/216988/
• Injectable Supramolecular Hydrogels for In Situ Programming of CAR-T Cells towards Solid Tumor Immunotherapy (Advanced Materials) https://www.stemcellsciencenews.com/newsletter/217350/

Neural Cell News

• iPS-Cell-Derived Microglia Promote Brain Organoid Maturation via Cholesterol Transfer (Nature) https://www.stemcellsciencenews.com/newsletter/216764/
• Neuronal TIMP2 Regulates Hippocampus-Dependent Plasticity and Extracellular Matrix Complexity (Molecular Psychiatry) https://www.stemcellsciencenews.com/newsletter/216828/
• A Purkinje Cell to Parabrachial Nucleus Pathway Enables Broad Cerebellar Influence over the Forebrain (Nature Neuroscience) https://www.stemcellsciencenews.com/newsletter/216884/
• A Neurodegeneration Checkpoint Mediated by REST Protects against the Onset of Alzheimer’s Disease (Nature Communications) https://www.stemcellsciencenews.com/newsletter/216883/
• A Spinal Cord Neuroprosthesis for Locomotor Deficits Due to Parkinson’s Disease (Nature Medicine) https://www.stemcellsciencenews.com/newsletter/216959/
• Selective Plasticity of Fast and Slow Excitatory Synapses on Somatostatin Interneurons in Adult Visual Cortex (Nature Communications) https://www.stemcellsciencenews.com/newsletter/217048/
• Peptide-Based Approaches to Directly Target Alpha-Synuclein in Parkinson’s Disease (Molecular Neurodegeneration) https://www.stemcellsciencenews.com/newsletter/217202/
• STING Signaling in the Brain: Molecular Threats, Signaling Activities, and Therapeutic Challenges (Neuron) https://www.stemcellsciencenews.com/newsletter/217203/
• Chemogenetic Approaches Reveal Dual Functions of Microglia in Seizures (Brain Behavior And Immunity) https://www.stemcellsciencenews.com/newsletter/217199/
• The Circadian Clock Time Tunes Axonal Regeneration (Cell Metabolism) https://www.stemcellsciencenews.com/newsletter/217272/
• Targeted Suppression of mTORC2 Reduces Seizures across Models of Epilepsy (Nature Communications) https://www.stemcellsciencenews.com/newsletter/217307/
• Knockout or Inhibition of USP30 Protects Dopaminergic Neurons in a Parkinson’s Disease Mouse Model (Nature Communications) https://www.stemcellsciencenews.com/newsletter/217305/
• Altered Corollary Discharge Signaling in the Auditory Cortex of a Mouse Model of Schizophrenia Predisposition (Nature Communications) https://www.stemcellsciencenews.com/newsletter/217399/
• Molecular Biomarkers for Vascular Cognitive Impairment and Dementia (Nature Reviews Neurology) https://www.stemcellsciencenews.com/newsletter/217469/
• Mitigating Aberrant Cdk5 Activation Alleviates Mitochondrial Defects and Motor Neuron Disease Symptoms in Spinal Muscular Atrophy (Proceedings Of The National Academy Of Sciences Of The United States Of America) https://www.stemcellsciencenews.com/newsletter/217558/
• Characterization of Neuromuscular Transmission and Projections of Muscle Motor Neurons in the Rat Stomach (American Journal Of Physiology-Gastrointestinal And Liver Physiology) https://www.stemcellsciencenews.com/newsletter/217662/
• Asteroid Impact: The Potential of Astrocytes to Modulate Human Neural Networks within Organoids (Frontiers In Neuroscience) https://www.stemcellsciencenews.com/newsletter/217763/
• Sequential Appetite Suppression by Oral and Visceral Feedback to the Brainstem (Nature) https://www.stemcellsciencenews.com/newsletter/217762/
• Third-Generation Rabies Viral Vectors Allow Nontoxic Retrograde Targeting of Projection Neurons with Greatly Increased Efficiency (Cell Reports Methods) https://www.stemcellsciencenews.com/newsletter/218092/
• Disruption of the Autism Gene and Chromatin Regulator KDM5A Alters Hippocampal Cell Identity (Science Advances) https://www.stemcellsciencenews.com/newsletter/218132/

Organoid Cell News

• The Drug Efficacy Testing in 3D Cultures Platform Identifies Effective Drugs for Ovarian Cancer Patients (NPJ Precision Oncology) https://www.stemcellsciencenews.com/newsletter/216766/
• Using Picoliter Droplet Deposition to Track Clonal Competition in Adherent and Organoid Cancer Cell Cultures (Scientific Reports) https://www.stemcellsciencenews.com/newsletter/216765/
• Cancer-on-Chip Models for Metastasis: Importance of the Tumor Microenvironment (Trends In Biotechnology) https://www.stemcellsciencenews.com/newsletter/216829/
• SARS-CoV-2 Infection Engenders Heterogeneous Ribonucleoprotein Interactions to Impede Translation Elongation in the Lungs (Experimental & Molecular Medicine) https://www.stemcellsciencenews.com/newsletter/216841/
• In-Organoid Single-Cell CRISPR Screening Reveals Determinants of Hepatocyte Differentiation and Maturation (Genome Biology) https://www.stemcellsciencenews.com/newsletter/217081/
• Potential Application of Intestinal Organoids in Intestinal Diseases (Stem Cell Reviews and Reports) https://www.stemcellsciencenews.com/newsletter/217179/
• Ascorbate Protects Human Kidney Organoids From Damage Induced by Cell-Free Hemoglobin (Disease Models & Mechanisms) https://www.stemcellsciencenews.com/newsletter/217178/
• Hepatitis C Virus Infects and Perturbs Liver Stem Cells (mBio) https://www.stemcellsciencenews.com/newsletter/217177/
• Patient-Derived Organoids Identify Tailored Therapeutic Options and Determinants of Plasticity in Sarcomatoid Urothelial Bladder Cancer (npj Precision Oncology) https://www.stemcellsciencenews.com/newsletter/217175/
• Reconstruction of Dynamic Mammary Mini Gland In Vitro for Normal Physiology and Oncogenesis (Nature Methods) https://www.stemcellsciencenews.com/newsletter/217171/
• Human Intestinal Organoids From Cronkhite-Canada Syndrome Patients Reveal Link Between Serotonin and Proliferation (Journal Of Clinical Investigation) https://www.stemcellsciencenews.com/newsletter/217172/
• Cochlear Organoids Reveal Transcriptional Programs of Postnatal Hair Cell Differentiation from Supporting Cells (Cell Reports) https://www.stemcellsciencenews.com/newsletter/217311/
• Modular 3D Printed Platform for Fluidically Connected Human Brain Organoid Culture (Biofabrication) https://www.stemcellsciencenews.com/newsletter/217310/
• Recent Advances in Lung Organoid Development and Applications in Disease Modeling (Journal Of Clinical Investigation) https://www.stemcellsciencenews.com/newsletter/217398/
• Single-Cell Transcriptomics Stratifies Organoid Models of Metabolic Dysfunction-Associated Steatotic Liver Disease (EMBO Journal) https://www.stemcellsciencenews.com/newsletter/217395/
• Human Intestinal Organoids: Modeling Gastrointestinal Physiology and Immunopathology – Current Applications and Limitations (European Journal Of Immunology) https://www.stemcellsciencenews.com/newsletter/217496/
• Stress-Free Cell Aggregation by Using the CEPT Cocktail Enhances Embryoid Body and Organoid Fitness (Biofabrication) https://www.stemcellsciencenews.com/newsletter/217605/
• Engineered Synthetic Matrices for Human Intestinal Organoid Culture And Therapeutic Delivery (Advanced Materials) https://www.stemcellsciencenews.com/newsletter/217768/
• Deriving Early Single-Rosette Brain Organoids from Human Pluripotent Stem Cells (Stem Cell Reports) https://www.stemcellsciencenews.com/newsletter/217766/
• NOTCH3 Signaling Controls Human Trophoblast Stem Cell Expansion and Differentiation (Development) https://www.stemcellsciencenews.com/newsletter/217797/
• Multi-Chamber Cardioids Unravel Human Heart Development and Cardiac Defects (Cell) https://www.stemcellsciencenews.com/newsletter/218150/

October 2023

• The Role of Zfp352 in the Regulation of Transient Expression of 2-Cell Specific Genes in Mouse Embryonic Stem Cells (Genes to Cells)
• Telomeric DNA Breaks in Human Induced Pluripotent Stem Cells Trigger ATR-Mediated Arrest and Telomerase-Independent Telomere Damage Repair   (Journal of Molecular Cell Biology)
• Transcriptomic Analysis of PADI4 Target Genes during Multi-Lineage Differentiation of Embryonic Stem Cells  (Philosophical Transactions Of The Royal Society B-Biological Sciences)
• The Efficient Generation of Functional Human Hepatocytes from Chemically Induced Pluripotent Stem Cells (Cell Proliferation)
• Fabrication of Shape-Designable Cartilage from Human Induced Pluripotent Stem Cell-Derived Chondroprogenitors Using a Cell Self-Aggregation Technique  (Biomedical Materials)
• Functional Interrogation of Twenty Type 2 Diabetes-Associated Genes Using Isogenic Human Embryonic Stem Cell-Derived β-Like Cells (Cell Metabolism)
• BRD9-Mediated Control of the TGF-β/Activin/Nodal Pathway Regulates Self-Renewal and Differentiation of Human Embryonic Stem Cells and Progression of Cancer Cells (Nucleic Acids Research)
• Investigation of Immune-Related Diseases Using Patient-Derived Induced Pluripotent Stem Cells(Inflammation and Regeneration)

Cell Therapy News

• A Deregulated m6A Writer Complex Axis Driven by BRD4 Confers an Epitranscriptomic Vulnerability in Combined DNA Repair–Targeted Therapy (Proceedings Of The National Academy Of Sciences Of The United States Of America)
• Preclinical Development of a Chimeric Antigen Receptor T Cell Therapy Targeting FGFR4 in Rhabdomyosarcoma (Cell Reports Medicine)
• Involving Stemness Factors to Improve CAR T-Cell-Based Cancer Immunotherapy (Medical Oncology)
• Impact of Targeting Moiety Type and Protein Corona Formation on the Uptake of Fn14-Targeted Nanoparticles by Cancer Cells (ACS Nano)
• Sustained Long-Term Disease Correction in a Murine Model of MPSII Following Stem Cell Gene Therapy (Molecular Therapy-Methods & Clinical Development)
• Mind the GAP: RASA2 and RASA3 GTPase-Activating Proteins As Gatekeepers of T Cell Activation and Adhesion (Trends in Immunology)
• Synthetic Transcription Factor Engineering for Cell and Gene Therapy (Trends In Biotechnology)
• NKGen Biotech Announces FDA Clearance of Investigational New Drug Application for SNK01 NK Cell Therapy to Treat Alzheimer’s Disease (NKGen Biotech Inc.)

Neural News

• Fe65-Engineered Neuronal Exosomes Encapsulating Corynoxine-B Ameliorate Cognition and Pathology of Alzheimer’s Disease (Signal Transduction and Targeted Therapy)
• Clinical Trial Links Oncolytic Immunoactivation to Survival in Glioblastoma (Nature)
• Crosstalk between Small-Cell Lung Cancer Cells and Astrocytes Mimics Brain Development to Promote Brain Metastasis (Nature Cell Biology)
• A Humanized Chemogenetic System Inhibits Murine Pain-Related Behavior and Hyperactivity in Human Sensory Neurons (Science Translational Medicine)
• Models for Evaluating Glioblastoma Invasion along White Matter Tracts (Trends in Biotechnology)
• Subventricular Zone Cytogenesis Provides Trophic Support for Neural Repair in a Mouse Model of Stroke (Nature Communications)
• Microglia and Complement Mediate Early Corticostriatal Synapse Loss and Cognitive Dysfunction in Huntington’s Disease (Nature Medicine)
• This Is the Largest Map of the Human Brain Ever Made (Nature)
• HMGA2 Directly Mediates Chromatin Condensation in Association with Neuronal Fate Regulation (Nature Communications)
• Dexmedetomidine Alleviates Cognitive Impairment by Promoting Hippocampal Neurogenesis via BDNF/TrkB/CREB Signaling Pathway in Hypoxic–Ischemic Neonatal Rats (CNS Neuroscience & Therapeutics)

Organoid News

• Establishment of a 96-Well Transwell System Using Primary Human Gut Organoids to Capture Multiple Quantitative Pathway Readouts (Scientific Reports)
• Efficient Genetic Editing of Human Intestinal Organoids Using Ribonucleoprotein-Based CRISPR (Disease Models & Mechanisms)
• Mapping Oto-Pharyngeal Development in a Human Inner Ear Organoid Model (Development)  A Scalable Human Islet 3D-Culture Platform Maintains Cell Mass and Function Long-Term for Transplantation (American Journal Of Transplantation)
• Tissue Morphology Influences the Temporal Program of Human Brain Organoid Development (Cell Stem Cell)
• Characterization and AAV-Mediated CRB Gene Augmentation in Human Derived CRB1^KO and CRB1^KOCRB2^+/- Retinal Organoids (Molecular Therapy-Methods & Clinical Development)
• Deciphering Neuronal Deficit and Protein Profile Changes in Human Brain Organoids from Patients with Creatine Transporter Deficiency (eLife)
• Unlocking the Potential of Organoids in Cancer Treatment and Translational Research: An Application of Cytologic Techniques (Cancer Cytopathology)
• Induced Regeneration of Articular Cartilage: Identification of a Dormant Regeneration Program for a Non-regenerative Tissue Icon for the Forest of Biologists (Development)
• Systematic Review: Predictive Value of Organoids in Colorectal Cancer (Scientific Reports)

September 2023

• GATA1 Deletion in Human Pluripotent Stem Cells Increases Differentiation Yield and Maturity of Neutrophils (iScience)
• CHK1-CDC25A-CDK1 Regulate Cell Cycle Progression and Protect Genome Integrity in Early Mouse Embryos (EMBO Reports)
• Recent Advances in Regulating the Proliferation or Maturation of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes (Stem Cell Research & Therapy)
• Comparison of miRNA Transcriptome of Exosomes in Three Categories of Somatic Cells with Derived iPSCs (Scientific Data)
• Directed Differentiation of Human Pluripotent Stem Cells into Articular Cartilage Reveals Effects Caused by Absence of WISP3, the Gene Responsible for Progressive Pseudorheumatoid Arthropathy of Childhood  (Cytotherapy)
• Trichostatin A for Efficient CRISPR-Cas9 Gene Editing of Human Pluripotent Stem Cells (CRISPR Journal)
• KLF4 Facilitates Chromatin Accessibility Remodeling in Porcine Early Embryos (Science China Life Sciences)
• DUX4 Expression in Cancer Induces a Metastable Early Embryonic Totipotent Program (Cell Reports)
• Uncovering the Role of FOXA2 in the Development of Human Serotonin Neurons (Advanced Science)
• Human Trials of Artificial Wombs Could Start Soon. Here’s What You Need to Know (Nature News)
• Cardiac Involvement in Patient-Specific Induced Pluripotent Stem Cells of Myotonic Dystrophy Type 1: Unveiling the Impact of Voltage-Gated Sodium Channels (Frontiers in Physiology)
• Deepening the Role of Excitation/Inhibition Balance in Human iPSCs-Derived Neuronal Networks Coupled to MEAs during Long-Term Development (Journal of Neural Engineering)
• Accelerated Differentiation of Human Induced Pluripotent Stem Cells into Regionally Specific Dorsal and Ventral Spinal Neural Progenitor Cells for Application in Spinal Cord Therapeutics (Frontiers in Neuroscience)
• Mini-TCRs: Truncated T Cell Receptors to Generate T Cells from Induced Pluripotent Stem Cells (Molecular Therapy-Methods & Clinical Development)
• Monolayer Platform to Generate and Purify Primordial Germ-Like Cells In Vitro Provides Insights into Human Germline Specification (Nature Communications)
• Induced Pluripotent Stem Cells: Ex Vivo Models for Human Diseases Due to Mitochondrial DNA Mutations (Journal of Biomedical Science)
• TOBF1 Modulates Mouse Embryonic Stem Cell Fate through Regulating Alternative Splicing of Pluripotency Genes (Cell Reports)

August 2023

• Manipulating and Studying Gene Function in Human Pluripotent Stem Cell Models (FEBS Letters)
• Rat Post-Implantation Epiblast-Derived Pluripotent Stem Cells Produce Functional Germ Cells (Cell Reports Methods)
• NAT10-Mediated N4-Acetylcytidine mRNA Modification Regulates Self-Renewal in Human Embryonic Stem Cells (Nucleic Acids Research)
• Country-Specific Regulation and International Standardization of Cell-Based Therapeutic Products Derived from Pluripotent Stem Cells (Stem Cell Reports)
• Female Naïve Human Pluripotent Stem Cells Carry X Chromosomes with Xa-Like and Xi-Like Folding Conformations (Science Advances)
• A Fast Chemical Reprogramming System Promotes Cell Identity Transition through a Diapause-Like State (Nature Cell Biology)
• Distinct Characteristics of Two Types of Alternative Lengthening of Telomeres in Mouse Embryonic Stem Cells (Nucleic Acids Research)
• The MORC2 p.S87L Mutation Reduces Proliferation of Pluripotent Stem Cells Derived from a Patient with the Spinal Muscular Atrophy-Like Phenotype by Inhibiting Proliferation-Related Signaling Pathways (Journal Of Immunotherapy)
• Utilizing Human Induced Pluripotent Stem Cells to Study Atrial Arrhythmias in the Short QT Syndrome (Journal Of Molecular And Cellular Cardiology)
• Reprogramming iPSCs to Study Age-Related Diseases: Models, Therapeutics, and Clinical Trials (Mechanisms Of Ageing And Development)
• Cell-Type-Specific Regulation of APOE and CLU Levels in Human Neurons by the Alzheimer’s Disease Risk Gene SORL1 (Cell Reports)
• Enhancing Viability of Human Embryonic Stem Cells during Cryopreservation via RGD-REP-Mediated Activation of FAK/AKT/FoxO3a Signaling Pathway (Tissue Engineering And Regenerative Medicine)
• Control of Stem Cell Renewal and Fate by YAP and TAZ (Nature Reviews Molecular Cell Biology)
• Haspin Balances the Ratio of Asymmetric Cell Division Through Wnt5a and Regulates Cell Fate Decisions in Mouse Embryonic Stem Cells (Cell Death Discovery)
• Effects of Low Doses of Methylmercury (MeHg) Exposure on Definitive Endoderm Cell Differentiation in Human Embryonic Stem Cells (Archives Of Toxicology)
• Improved Cryopreservation of Human Induced Pluripotent Stem Cell (iPSC) and iPSC Derived Neurons Using Ice-Recrystallization Inhibitors (Stem Cells)
• Wnt and BMP Signaling Direct Anterior/Posterior Differentiation in Aggregates of Mouse Embryonic Stem Cells (Biology Open)
• The Induction of Parathyroid Cell Differentiation from Human Induced Pluripotent Stem Cells Promoted via TGF-α/EGFR Signaling (Stem Cells And Development)
• Single-Molecule Tracking of Nanog and Oct4 in Living Mouse Embryonic Stem Cells Uncovers a Feedback Mechanism of Pluripotency Maintenance (EMBO Journal)

July 2023

• Building Human Artery and Vein Endothelial Cells from Pluripotent Stem Cells, and Enduring Mysteries Surrounding Arteriovenous Development (Seminars in Cell & Developmental Biology)
• Derivation and Characteristics of Induced Pluripotent Stem Cells from a Patient with Acute Myelitis (Frontiers In Cell And Developmental Biology)
• Chemical Genomics Reveals Targetable Programs of Human Cancers Rooted in Pluripotency (Cell Chemical Biology)
• ZMYM2 Is Essential for Methylation of Germline Genes and Active Transposons in Embryonic Development (Nucleic Acids Research)
• Artificial Induction of Circadian Rhythm by Combining Exogenous BMAL1 Expression and Polycomb Repressive Complex 2 Inhibition in Human Induced Pluripotent Stem Cells (Cellular and Molecular Life Sciences)
• Effective SARS-CoV-2 Replication of Monolayers of Intestinal Epithelial Cells Differentiated from Human Induced Pluripotent Stem Cells (Scientific Reports)
• Human Trophoblast Stem Cell-State Acquisition from Pluripotent Stem Cells and Somatic Cells (Current Opinion in Genetics & Development)
• Restricting Epigenetic Activity Promotes the Reprogramming of Transformed Cells to Pluripotency in a Line-Specific Manner (Cell Death Discovery)
• Crosstalk between RNA m6A and DNA Methylation Regulates Transposable Element Chromatin Activation and Cell Fate in Human Pluripotent Stem Cells (Nature Genetics)

June 2023

• Pluripotency-Independent Induction of Human Trophoblast Stem Cells from Fibroblasts (Nature Communications) 
• Human Embryonic Stem Cells Exert Antitumor Effects on Prostate Cancer Cells in a Co-Culture Microenvironment (Frontiers In Oncology) 
• LIS1 RNA-Binding Orchestrates the Mechanosensitive Properties of Embryonic Stem Cells in AGO2-Dependent and Independent Ways (Nature Communications) 
• Identification and Functional Evaluation of Alternative Splice Variants of Dax1 in Mouse Embryonic Stem Cells (Stem Cells And Development) 
• The Circadian Clock CRY1 Regulates Pluripotent Stem Cell Identity and Somatic Cell Reprogramming (Cell Reports) 
• On-Chip Real-Time Impedance Monitoring of hiPSC-Derived and Artificial Basement Membrane-Supported Endothelium (Bioactive Materials)
• Suspension Culture Improves iPSC Expansion and Pluripotency Phenotype (Current Stem Cell Research & Therapy) 
• Apicobasal RNA Asymmetries Regulate Cell Fate in the Early Mouse Embryo (Nature Communications) 
• Pluripotency-Independent Induction of Human Trophoblast Stem Cells from Fibroblasts (Nature Communications) 
• Harnessing Three-Dimensional (3D) Cell Culture Models for Pulmonary Infections: State of the Art and Future Directions (Naunyn-Schmiedebergs Archives Of Pharmacology) 
• Generation of an Induced Pluripotent Stem Cell Lines NSHDMUi001-A from Patients with Type 2 Diabetes (Stem Cell Research)
• GSK-3α/β and MEK Inhibitors Assist the Microenvironment of Tumor Initiation (Cytotechnology)
• A Model of the Post-implantation Human Embryo Derived from Pluripotent Stem Cells (Nature) 
• Self-Patterning of Human Stem Cells into Post-implantation Lineages (Nature)  
• Most Advanced Synthetic Human Embryos Yet Spark Controversy (Nature News) 
• Sequential and Directional Insulation by Conserved CTCF Sites Underlies the Hox Timer in Stembryos (Nature Genetics) 
• Cell-Membrane-Coated and Cell-Penetrating Peptide-Conjugated Trimagnetic Nanoparticles for Targeted Magnetic Hyperthermia of Prostate Cancer Cells [ACS Applied Materials & Interfaces] 
• Comparative Landscape of Genetic Dependencies in Human and Chimpanzee Stem Cells (Cell) 
• Overcoming the H4K20me3 Epigenetic Barrier Improves Somatic Cell Nuclear Transfer Reprogramming Efficiency in Mice (Cell Proliferation) 
• Reprogramming Human Female Adipose Mesenchymal Stem Cells into Primordial Germ Cell-Like Cells (Stem Cell Reviews And Reports)  
• An O-GlcNAc Transferase Pathogenic Variant Linked to Intellectual Disability Affects Pluripotent Stem Cell Self-Renewal (Disease Models & Mechanisms) 
• Generation of Two Induced Pluripotent Stem Cell Lines and the Corresponding Isogenic Controls from Parkinson’s Disease Patients Carrying the Heterozygous Mutations c.815G > a (p.R272Q) or c.1348C > T (p.R450C) in the RHOT1 Gene Encoding Miro1 )Stem Cell Research) 
• Generation of Induced Pluripotent Stem Cell Line (XWHNi002-a) from a Female with APP Gene Mutation (Stem Cell Research) 
• Human Induced Pluripotent Stem Cell-Derived Pericytes as Scalable and Editable Source to Study Direct Lineage Reprogramming Into Induced Neurons (Cellular Reprogramming) 
• Human Prostate Organoid Generation and the Identification of Prostate Development Drivers Using Inductive Rodent Tissues (Development) 
• A Model of the Post-implantation Human Embryo Derived from Pluripotent Stem Cells (Nature) 
• Self-Patterning of Human Stem Cells into Post-implantation Lineages (Nature) 

May 2023

• Identification of an Adipose Tissue-Resident Pro-Preadipocyte Population (Cell Reports) 
• Optogenetic Manipulation Identifies the Roles of ERK and AKT Dynamics in Controlling Mouse Embryonic Stem Cell Exit from Pluripotency (Developmental Cell) 
• Human Embryo Science: Can the World’s Regulators Keep Pace?(Nature News) 
• Esrrb Guides Naive Pluripotent Cells through the Formative Transcriptional Programme (Nature Cell Biology) 
• Acoel Single-Cell Atlas Reveals Expression Dynamics and Heterogeneity of Adult Pluripotent Stem Cells (Nature Communications) 
• Hypo immune Induced Pluripotent Stem Cells Survive Long Term in Fully Immunocompetent, Allogeneic Rhesus Macaques 
• (Nature Biotechnology) https://www.nature.com/articles/s41587-023-01784-x
• Embryonic Stem Cell ERK, AKT, Plus STAT3 Response Dynamics Combinatorics Are Heterogeneous but NANOG State Independent (Stem Cell Reports) 
• Generation of iPSC-Derived Human Forebrain Organoids Assembling Bilateral Eye Primordia (Nature Protocols) 
• A CRISPR-Engineered Isogenic Model of the 22q11.2 A-B Syndromic Deletion (Scientific Reports) 
• Cellular Population Dynamics Shape the Route to Human Pluripotency 
• (Nature Communications) https://www.nature.com/articles/s41467-023-37270-w
• The Effect of Vitamin D3 and Valproic Acid on the Maturation of Human Induced Pluripotent Stem Cell-Derived Enterocyte-Like Cells (Stem Cells) https://academic.oup.com/stmcls/advance-article-abstract/doi/10.1093/stmcls/sxad042/7179740?redirectedFrom=fulltext&login=false
• RNA Stability Controlled by m6A Methylation Contributes to X-to-Autosome Dosage Compensation in Mammals (Nature Structural & Molecular Biology) 
• Apicobasal RNA Asymmetries Regulate Cell Fate in the Early Mouse Embryo (Nature Communications) 
• Propensity of Patient-Derived iPSCs for Retinal Differentiation: Implications for Autologous Cell Replacement (Stem Cells Translational Medicine)  
• Critically Short Telomeres Derepress Retrotransposons to Promote Genome Instability in Embryonic Stem Cells (Cell Discovery) 
• USP7 Represses Lineage Differentiation Genes in Mouse Embryonic Stem Cells by Both Catalytic and Noncatalytic Activities (Science Advances) 
• Extensive Programmed Centriole Elimination Unveiled in C. elegans Embryos (Science Advances) 
• Ablation of ZC3H11A Causes Early Embryonic Lethality and Dysregulation of Metabolic Processes 
• [Proceedings Of The National Academy Of Sciences Of The United States Of America] 
• Reprogramming of Three-Dimensional Chromatin Organization in the Early Embryo 
• (Current Opinion In Structural Biology) 
• Mesodermal FGF and BMP Govern the Sequential Stages of Zebrafish Thyroid Specification (Development) 
• Differentiation and Single-Cell RNA-Seq Analyses of Human Pluripotent-Stem-Cell-Derived Renal Organoids (Star Protocols) 
• The Promises and Pitfalls of CRISPR-Mediated Base Editing in Stem Cells (CRISPR Journal)https://www.liebertpub.com/doi/10.1089/crispr.2023.0013
• First Female Arab Astronaut Reaches ISS for Historic Mission to Conduct Stem Cell & Cancer Research (The Free Press Journal) 
• Is Space the Place for Stem Cell Manufacturing? Scientists Will Soon Test That on the ISS (FierceBiotech) 
• Modulation of WNT, Activin/Nodal, and MAPK Signaling Pathways Increases Arterial Hemogenic Endothelium and Hematopoietic Stem/Progenitor Cell Formation during Human iPSC Differentiation (Stem Cells) 
• MutSα and MutSβ as Size-Dependent Cellular Determinants for Prime Editing in Human Embryonic Stem Cells (Molecular Therapy – Nucleic Acids) 
• Generation of Stable Integration-Free Pig Induced Pluripotent Stem Cells under Chemically Defined Culture Condition (Cell Proliferation) 
• Parallel Genome-Wide CRISPR Screens to Identify State-Dependent Self-Renewal Regulators of Mouse Embryonic Stem Cells (Stem Cells and Development) 
• CRISPR/Cas9 Assisted Stem Cell Therapy in Parkinson’s Disease (Biomaterials Research) 
• The RNA Cap Methyltransferases RNMT and CMTR1 Co-Ordinate Gene Expression during Neural Differentiation (Biochemical Society Transactions) 
• BCL2 Is a Major Regulator of Haploidy Maintenance in Murine Embryonic Stem Cells (Cell Proliferation)
• Deriving Schwann Cells from hPSCs Enables Disease Modeling and Drug Discovery for Diabetic Peripheral Neuropathy (Cell Stem Cell)
• Establishment of Bovine Trophoblast Stem Cells (Cell Report)
• https://www.cell.com/cell-reports/fulltext/S2211-1247(23)00450-3
• Chemically Defined Production of Tri-Lineage Human iPSC-Derived Cardiac Spheroids (Current Protocols) 
• Differentiation of Stem Cell-Derived Pancreatic Progenitors into Insulin-Secreting Islet Clusters in a Multiwell-Based Static 3D Culture System (Cell Reports Methods) 
• A Transcriptomic Signature of X Chromosome Overdosage in Saudi Klinefelter Syndrome Induced Pluripotent Stem Cells (Endocrine Connections) 
• Patient-Specific Induced Pluripotent Stem Cell Properties Implicate Ca2+-Homeostasis in Clinical Arrhythmia Associated with Combined Heterozygous RYR2 and SCN10A Variants (Philosophical Transactions Of The Royal Society B-Biological Sciences) 
• The Generation and Properties of Human Cortical Organoids as a Disease Model for Malformations of Cortical Development (Neural Regeneration Research) 
• Efficient and Rapid Fluorescent Protein Knock-In with Universal Donors in Mouse Embryonic Stem Cells (Development) 
• A Desert lncRNA HIDEN Regulates Human Endoderm Differentiation via Interacting with IMP1 and Stabilizing FZD5 mRNA (Genome Biology)
• Modeling Human Skeletal Development Using Human Pluripotent Stem Cells 
• (Proceedings Of The National Academy Of Sciences Of The United States Of America) 

April 2023

• A human induced pluripotent stem cell model from a patient with hereditary cerebral small vessel disease carrying a heterozygous R302Q mutation in HTRA1 (Inflammation and Regeneration) 
• Development of substrates for the culture of human pluripotent stem cells (Biomaterials Science) 
• Albumin-Based Solution Is the Ideal Post-thawing Suspension Medium for Cord Blood Hematopoietic Stem Cells: A Stability and Proliferative Evaluation (Transfusion) 
• Brain p3-Alcβ Peptide Restores Neuronal Viability Impaired by Alzheimer’s Amyloid β-Peptide (EMBO Molecular Medicine) 
• Extracellular Vesicles in Tumor Angiogenesis and Resistance to Anti-Angiogenic Therapy (Cancer Science) 
• Gene Editing to Prevent Ventricular Arrhythmias Associated with Cardiomyocyte Cell Therapy (Cell Stem Cell) 
• Hematopoietic Stem-Cell Gene Therapy Is Associated with Restored White Matter Microvascular Function in Cerebral Adrenoleukodystrophy (Nature Communications) 
• Interleukin-1 Receptor Antagonist: A Promising Cytokine against Human Squamous Cell Carcinomas (Heliyon) 
• Modelling Hyperexcitability in Human Cerebral Cortical Organoids: Oxygen/Glucose Deprivation Most Effective Stimulant (Heliyon) 
• Pluripotent, Germ Cell Competent Adult Stem Cells Underlie Cnidarian Regenerative Ability and Clonal Growth (Current Biology) 
• Rif1 Regulates Self-Renewal and Impedes Mesendodermal Differentiation of Mouse Embryonic Stem Cells (Stem Cell Reviews and Reports) 
• Scalable generation of sensory neurons from human pluripotent stem cells (STEM CELL REPORTS) 
• Optimized whole-genome CRISPR interference screens identify ARID1A-dependent growth regulators in human induced pluripotent stem cells (STEM CELL REPORTS) 
• Neurite outgrowth deficits caused by rare PLXNB1 mutation in pediatric bipolar disorder (Molecular Psychiatry) 
• A hydrogel model of the human blood-brain barrier using differentiated stem cells (PLOS ONE) 
• Dynamic Changes in Heparan Sulfate Nanostructure in Human Pluripotent Stem Cell Differentiation (ACS Nano) 
• Induced pluripotent stem cell technology in bone biology (Science Direct) 
• Trajectory reconstruction identifies dysregulation of perinatal maturation programs in pluripotent stem cell-derived cardiomyocytes (Cell Reports) 
• Engineering Alignment Has Mixed Effects on Human Induced Pluripotent Stem Cell Differentiated Cardiomyocyte Maturation (Tissue Engineering Part A) 
• Secretive Derived from Hypoxia Preconditioned Mesenchymal Stem Cells Promote Cartilage Regeneration and Mitigate Joint Inflammation via Extracellular Vesicles (Bioactive Materials) 
• Skeletal Muscle Gene Expression Dysregulation in Long-Term Spaceflights and Aging Is Clock-Dependent (NPJ Microgravity) 

• Advancing Cell Therapy for Neurodegenerative Diseases (Cell Stem Cell) 

• A Multi-Omics Integrative Analysis Based on CRISPR Screens Re-defines the Pluripotency Regulatory Network in ESCs (Communications Biology) 
• Cancer Neuroscience: State of the Field, Emerging Directions (Cell) 
• CRISPR-Based Functional Genomics Screening in Human-Pluripotent-Stem-Cell-Derived Cell Types(Cell Genomics) 
• DC Vaccine Enhances CAR-T Cell Antitumor Activity by Overcoming T Cell Exhaustion and Promoting T Cell Infiltration in Solid Tumors (Clinical And Translational Oncology) 
• Decoding the Molecular Crosstalk between Grafted Stem Cells and the Stroke-Injured Brain (Cell Reports) 
• Human iPSC-Derived Neural Progenitor Cells Secreting GDNF Provide Protection in Rodent Models of ALS and Retinal Degeneration (Stem Cell Reports) 
• MicroRNA-146a Promotes Embryonic Stem Cell Differentiation towards Vascular Smooth Muscle Cells through Regulation of Kruppel-like Factor 4 (Current Medical Science)
• Mechanisms of Resistance and Treatment of Relapse After CAR T-Cell Therapy for Large B-Cell Lymphoma and Multiple Myeloma (Transplantation And Cellular Therapy)
• Progress and Emerging Techniques for Biomaterial-Based Derivation of Mesenchymal Stem Cells (MSCs) from Pluripotent Stem Cells (PSCs) (Biomaterials Research)
• Transforming the Understanding of Brain Immunity (Science)
• An In Vivo Neuroimmune Organoid Model to Study Human Microglia Phenotypes (Cell)
• Directing iPSC Differentiation into iTenocytes Using Combined Scleraxis Overexpression and Cyclic Loading (Journal of Orthopaedic Research)
• Autologous Mesenchymal Stem Cells Offer a New Paradigm for Salivary Gland Regeneration(International Journal of Oral Science)
• Hypoimmune Induced Pluripotent Stem Cells Survive Long Term in Fully Immunocompetent, Allogeneic Rhesus Macaques(Nature Biotechnology)
• Rescue of GM3 Synthase Deficiency by Spatially Controlled, rAAV-Mediated ST3GAL5 Delivery (JCI Insight)
• Effects of HDAC Inhibitors on Neuroblastoma SH-SY5Y Cell Differentiation Into Mature Neurons via the Wnt Signaling Pathway (BMC Neuroscience)
• Deriving Schwann Cells from hPSCs Enables Disease Modeling and Drug Discovery for Diabetic Peripheral Neuropathy(Cell Stem Cell)
• Differentiation of Stem Cell-Derived Pancreatic Progenitors into Insulin-Secreting Islet Clusters in a Multiwell-Based Static 3D Culture System(Cell Reports Methods)
• A Transcriptomic Signature of X Chromosome Overdosage in Saudi Klinefelter Syndrome Induced Pluripotent Stem Cells (Endocrine connections)
• Patient-Specific Induced Pluripotent Stem Cell Properties Implicate Ca²⁺-Homeostasis in Clinical Arrhythmia Associated with Combined Heterozygous RYR2 and SCN10A Variants (Philosophical Transactions Of The Royal Society B-Biological Sciences)
• Mesenchymal Stem Cell-Derived Extracellular Vesicles Protect against Abdominal Aortic Aneurysm Formation by Inhibiting NET-Induced Ferroptosis (Communications Biology)
• Critically Short Telomeres Derepress Retrotransposons to Promote Genome Instability in Embryonic Stem Cells(Cell Discovery) https://www.nature.com/articles/s41421-023-00538-y

March 2023

• Dipeptidyl peptidase 4 Promotes Survival and Stemness of Acute Myeloid Leukemia Stem Cells (Cell Reports) 
• Generation of Self-Organized Autonomic Ganglion Organoids from Fibroblasts (iScience) 
• Human Gene-Engineered Calreticulin Mutant Stem Cells Recapitulate MPN Hallmarks and Identify Targetable Vulnerabilities (Leukemia) 
• Melatonin-Mediated FKBP4 Downregulation Protects against Stress-Induced Neuronal Mitochondria Dysfunctions by Blocking Nuclear Translocation of GR (Cell Death & Disease) 
• Patient-Derived Spheroids and Patient-Derived Organoids Simulate Evolutions of Lung Cancer (Heliyon) 
• Psychedelics Promote Neuroplasticity through the Activation of Intracellular 5-HT2A Receptors (Science) 

• A Multi-Organoid Platform Identifies CIART as a Key Factor for SARS-CoV-2 Infection (Nature Cell Biology) 
• Apoptosis Inhibition Enhances Induced Pluripotent Stem Cell Generation during T Cell Reprogramming (Biochemical and Biophysical Research Communications) 
• Clinical Use of CAR T-cells in Treating Acute Lymphoblastic Leukemia (Transfusion And Apheresis Science) 
• Dying Transplanted Neural Stem Cells Mediate Survival Bystander Effects in the Injured Brain (Cell Death & Disease) 
• Fibroblast Heterogeneity: Keystone of Tissue Homeostasis and Pathology in Inflammation and Aging (Frontiers In Immunology) 
• Generation of Functional Oocytes from Male Mice In Vitro (Nature) 
• Highly Efficient and Rapid Generation of Human Pluripotent Stem Cells by Chemical Reprogramming (Cell Stem Cell) 
• Improved Survival of Patients with Primary Plasma Cell Leukemia with VRd or Daratumumab-based Quadruplets: A Multicenter Study by the Greek Myeloma Study Group (American Journal Of Hematology)
• Implantation of Engineered Human Microvasculature to Study Human Infectious Diseases in Mouse Models (iScience) 
• The Novel GATA1-Interacting Protein HES6 Is an Essential Transcriptional Cofactor for Human Erythropoiesis (Nucleic Acids Research) 
• Very Small Embryonic-Like Stem Cells Transform into Cancer Stem Cells and Are Novel Candidates for Detecting/Monitoring Cancer by a Simple Blood Test (Stem Cells)

February 2023

• A Molecular Characterization and Clinical Relevance of Microglia-Like Cells Derived from Patients with Panic Disorder (Translational Psychiatry) 
• Bioengineering Approaches to Promote Maturity in Human Skeletal Muscle Constructs (Biophysical Journal) 
• Cancer Stem Cells: Recent Insights and Therapies (Biochemical Pharmacology) 
• Supports Meso-Endoderm Differentiation from Mouse Embryonic Stem Cells (Nature Communications) 
• Inflammation and DNA Damage: Cause, Effect or Both (Nature Reviews Rheumatology) 
• iPSC-Based Modeling of THD Recapitulates Disease Phenotypes and Reveals Neuronal Malformation (EMBO Molecular Medicine) 
• Lnc956-TRIM28-HSP90B1 Complex on Replication Forks Promotes CMG Helicase Retention to Ensure Stem Cell Genomic Stability and Embryogenesis (Science Advances) 
• Multicenter Long-Term Follow-Up of Allogeneic Hematopoietic Cell Transplantation with Omidubicel: A Pooled Analysis of Five Prospective Clinical Trials (Transplantation And Cellular Therapy) 
• NANOGP1, a Tandem Duplicate of NANOG, Exhibits Partial Functional Conservation in Human Naïve Pluripotent Stem Cells (Development) 
• Nanosheet Coating Improves Stability of Human Pluripotent Stem Cell Culture on Glass Substrates (Biochemical and Biophysical Research Communications) 
• Reversal of Aging-Associated Increase in Myelopoiesis and Expression of Alarmins by Angiotensin-(1–7) (Scientific Reports) 
• Transcriptional Reprogramming of Skeletal Muscle Stem Cells by the Niche Environment (Nature Communications) 
• Transgenic Skin Biomechanical Properties Following First Lifesaving Epidermal Regeneration Using Combined Gene and Cell Therapy (Journal of the German Society of Dermatology) 

January 2023

• Administration of Stem Cells against Cardiovascular Diseases with a Focus on Molecular Mechanisms: Current Knowledge and Prospects (Tissue and Cell) 
• Binary Colloidal Crystals Promote Cardiac Differentiation of Human Pluripotent Stem Cells via Nuclear Accumulation of SETDB1 (ACS Nano) 
• Corneal Stem Cells Niche and Homeostasis Impacts in Regenerative Medicine; Concise Review (European Journal of Ophthalmology) 
• Cross-Species Transcriptomic Atlas of Dorsal Root Ganglia Reveals Species-Specific Programs for Sensory Function (Nature Communications) 
• Endothelial Cell-Derived Exosomes Boost and Maintain Repair-Related Phenotypes of Schwann Cells via miR199-5p to Promote Nerve Regeneration (Journal Of Nanobiotechnology) 
• Generation of Urine-Derived Induced Pluripotent Stem Cells and Cerebral Organoids for Modeling Down Syndrome (Stem Cell Reviews and Reports) 
• Human iPSC-Derived Preclinical Models to Identify Toxicity of Tumor-Specific T Cells with Clinical Potential (Molecular Therapy-Methods & Clinical Development) 
• Photoreceptor Laminin Drives Differentiation of Human Pluripotent Stem Cells to Photoreceptor Progenitors That Partially Restore Retina Function (Molecular Therapy) 
• Progenitor-Derived Endothelin Controls Dermal Sheath Contraction for Hair Follicle Regression (Nature Cell Biology) 
• Protein Kinase C Modulation Determines the Mesoderm/Extraembryonic Fate under BMP4 Induction from Human Pluripotent Stem Cells (Stem Cells) 
• The Impact of the Cellular Environment and Aging on Modeling Alzheimer’s Disease in 3D Cell Culture Models (Advanced Science) 
• Transcriptional and Functional Effects of Lithium in Bipolar Disorder iPSC-Derived Cortical Spheroids (Molecular Psychiatry) 
• Transplanted Human iPSC-Derived Vascular Endothelial Cells Promote Functional Recovery by Recruitment of Regulatory T Cells to Ischemic White Matter in the Brain (Journal of Neuroinflammation) 

December 2022

·&²Ô²ú²õ±è;&²Ô²ú²õ±è;&²Ô²ú²õ±è;&²Ô²ú²õ±è;  RNA Degradation Eliminates Developmental Transcripts during Murine Embryonic Stem Cell Differentiation via CAPRIN1-XRN2 

·&²Ô²ú²õ±è;&²Ô²ú²õ±è;&²Ô²ú²õ±è;&²Ô²ú²õ±è;  Embryonic Origins of Adult Pluripotent Stem Cells 

·&²Ô²ú²õ±è;&²Ô²ú²õ±è;&²Ô²ú²õ±è;&²Ô²ú²õ±è;  Bulk RNA sequencing analysis of developing human induced pluripotent cell-derived retinal organoids 

·&²Ô²ú²õ±è;&²Ô²ú²õ±è;&²Ô²ú²õ±è;&²Ô²ú²õ±è;  Effect of thymoquinone on pharmacokinetics of 5-fluorouracil in rats and its effect on human cell line in vitro 

·&²Ô²ú²õ±è;&²Ô²ú²õ±è;&²Ô²ú²õ±è;&²Ô²ú²õ±è;  Stress-Induced Reversible Cell-Cycle Arrest Requires PRC2/PRC1-Mediated Control of Mitophagy in Drosophila Germline Stem Cells and Human iPSCs 

·&²Ô²ú²õ±è;&²Ô²ú²õ±è;&²Ô²ú²õ±è;&²Ô²ú²õ±è;  Plpp3, a novel regulator of pluripotency exit and endodermal differentiation of mouse embryonic stem cells 

·&²Ô²ú²õ±è;&²Ô²ú²õ±è;&²Ô²ú²õ±è;&²Ô²ú²õ±è;  Optimization of the proliferation and persistency of CAR T cells derived from human induced pluripotent stem cells 

·&²Ô²ú²õ±è;&²Ô²ú²õ±è;&²Ô²ú²õ±è;&²Ô²ú²õ±è;  CD34^dim cells identified as pluripotent stem cell-derived definitive hemogenic endothelium purified using bone morphogenetic protein 4 

·&²Ô²ú²õ±è;&²Ô²ú²õ±è;&²Ô²ú²õ±è;&²Ô²ú²õ±è;  A Reference Human Induced Pluripotent Stem Cell Line for Large-Scale Collaborative Studies 

·&²Ô²ú²õ±è;&²Ô²ú²õ±è;&²Ô²ú²õ±è;&²Ô²ú²õ±è;  The Consequences of Recurrent Genetic and Epigenetic Variants in Human Pluripotent Stem Cells 

·&²Ô²ú²õ±è;&²Ô²ú²õ±è;&²Ô²ú²õ±è;&²Ô²ú²õ±è;  Dialysis based-culture medium conditioning improved the generation of human induced pluripotent stem cell derived-liver organoid in a high cell density 

November 2022

• Long-Range Axonal Projections of Transplanted Mouse Embryonic Stem Cell-Derived Hypothalamic Neurons into Adult Mouse Brain (PLoS One) 
• Modeling Placental Development and Disease Using Human Pluripotent Stem Cells (Placenta)
• Transcription Factor Antagonism Regulates Heterogeneity in Embryonic Stem Cell States (Molecular Cell) 
• Membrane Potential Drives the Exit from Pluripotency and Cell Fate Commitment via Calcium and mTOR (Nature Communications) 
• Lamin A/C-dependent Chromatin Architecture Safeguards Naïve Pluripotency to Prevent Aberrant Cardiovascular Cell Fate and Function (Nature Communications) 
• Virtual Cells in a Virtual Microenvironment Recapitulate Early Development-Like Patterns in Human Pluripotent Stem Cell Colonies (Stem Cell Reports) 
• Stabilization of hESCs in Two Distinct Substrates along the Continuum of Pluripotency (iScience) 
• Acute Severe Hypoxia Induces Apoptosis of Human Pluripotent Stem Cells by a HIF-1α and P53 Independent Mechanism (Scientific Reports) 
• Intermediate Cells of In Vitro Cellular Reprogramming and In Vivo Tissue Regeneration Require Desmoplakin (Science Advances) 
• Transient Inhibition of p53 Enhances Prime Editing and Cytosine Base-Editing Efficiencies in Human Pluripotent Stem Cells (Nature Communications) 
• Stabilization of Cell-Cell Adhesions Prevents Symmetry Breaking and Locks In Pluripotency in 3D Gastruloids (Stem Cell Reports) 
• Nucleosome Breathing Facilitates Cooperative Binding of Pluripotency Factors Sox2 and Oct4 to DNA(Biophysical Journal) 
• Therapeutic Function of a Novel Rat Induced Pluripotent Stem Cell Line in a 6-OHDA-Induced Rat Model of Parkinson’s Disease (International Journal of Molecular Medicine]) 
• Embryonic Stem Cells Lacking DNA Methyltransferases Differentiate into Neural Stem Cells That Are Defective in Self-Renewal (International Journal of Stem Cells)
• Using Pluripotent Stem Cells to Understand Normal and Leukemic Hematopoietic Development (Stem Cells Translational Medicine) 

October 2022

World’s first stem cell treatment for spina bifida delivered during fetal surgery!    

• Identification of Stable Housekeeping Genes for Induced Pluripotent Stem Cells and -Derived Endothelial Cells for Drug Testing (Scientific Reports) https://www.nature.com/articles/s41598-022-20435-w
• TGFβ Superfamily Signaling Regulates the State of Human Stem Cell Pluripotency and Capacity to Create Well-Structured Telencephalic Organoids (Stem Cell Reports) https://www.cell.com/stem-cell-reports/fulltext/S2213-6711(22)00422-2
• The Kleisin Subunits of Cohesin Are Involved in the Fate Determination of Embryonic Stem Cells (Molecules and Cells) https://www.molcells.org/journal/view.html?doi=10.14348/molcells.2022.2042 
• Human Cellular Models for Retinal Disease: From Induced Pluripotent Stem Cells to Organoids (Retina-the Journal of Retinal and Vitreous Diseases) https://journals.lww.com/retinajournal/Abstract/2022/10000/HUMAN_CELLULAR_MODELS_FOR_RETINAL_DISEASE__From.1.aspx 
• Super-Enhancers Conserved within Placental Mammals Maintain Stem Cell Pluripotency (Proceedings of the National Academy of Sciences of the United States of America) https://www.pnas.org/doi/10.1073/pnas.2204716119 
• High Glucose Impairs Osteogenic Differentiation of Embryonic Stem Cells via Early Diversion of Beta-Catenin from Forkhead Box O to T Cell Factor Interaction (Birth Defects Research) https://onlinelibrary.wiley.com/doi/10.1002/bdr2.2085

September 2022

• Retinoic Acid Delays Initial Photoreceptor Differentiation and Results in a Highly Structured Mature Retinal Organoid (Stem Cell Research & Therapy) https://stemcellres.biomedcentral.com/articles/10.1186/s13287-022-03146-x
• Engineering Placenta-Like Organoids Containing Endogenous Vascular Cells from Human-Induced Pluripotent Stem Cells (Bioengineering & Translational Medicine) https://aiche.onlinelibrary.wiley.com/doi/full/10.1002/btm2.10390 
• Induction of Functional Xeno-Free MSCs from Human iPSCs via a Neural Crest Cell Lineage (NPJ Regenerative Medicine) https://www.nature.com/articles/s41536-022-00241-8
• CTCF Acetylation at Lysine 20 Is Required for the Early Cardiac Mesoderm Differentiation of Embryonic Stem Cells (Cell Regeneration) https://cellregeneration.springeropen.com/articles/10.1186/s13619-022-00131-w
• Evolutionary Origin of Vertebrate OCT4/POU5 Functions in Supporting Pluripotency (Nature Communications) https://www.nature.com/articles/s41467-022-32481-z
• Dominant Role of DNA Methylation over H3K9me3 for IAP Silencing in Endoderm (Nature Communications) https://www.nature.com/articles/s41467-022-32978-7
• LncRNA-Smad7 Mediates Cross-Talk between Nodal/TGF-β and BMP Signaling to Regulate Cell Fate Determination of Pluripotent and Multipotent Cells (Nucleic Acids Research) https://academic.oup.com/nar/advance-article/doi/10.1093/nar/gkac780/6711145
• Passage Number Affects Differentiation of Sensory Neurons from Human Induced Pluripotent Stem Cells (Scientific Reports) https://www.nature.com/articles/s41598-022-19018-6 
• Modeling Urea Cycle Disorders Using iPSCs (NPJ Regenerative Medicine) https://www.nature.com/articles/s41536-022-00252-5
• Building In Vitro Models of the Brain To Understand the Role of APOE in Alzheimer’s Disease [Life Science Alliance] https://www.life-science-alliance.org/content/5/11/e202201542 
• PFOS Disrupts Key Developmental Pathways during hiPSC Derived Cardiomyocyte Differentiation (In Vitro Toxicology in Vitro) https://www.sciencedirect.com/science/article/pii/S0887233322001734?via%3Dihub
• Imprinting Fidelity in Mouse iPSCs Depends on Sex of Donor Cell and Medium Formulation (Nature Communications) https://www.nature.com/articles/s41467-022-33013-55
• CRISPR-Cas9 Screen in Human Embryonic Stem Cells to Identify Genes Required for Neural Differentiation (STAR Protocols) https://www.sciencedirect.com/science/article/pii/S2666166722005627?via%3Dihub
• Different Transcriptional Profiles of Human Embryonic Stem Cells Grown in a Feeder-Free Culture System and on Human Foreskin Fibroblast Feeder Layers (Aging-Us) https://www.aging-us.com/article/204282/text
• Fast Generation of Forebrain Oligodendrocyte Spheroids from Human Embryonic Stem Cells by Transcription Factors (iScience) https://www.cell.com/action/showPdf?pii=S2589-0042%2822%2901444-4
• METTLing in Stem Cell and Cancer Biology (Stem Cell Reviews and Reports) https://link.springer.com/article/10.1007/s12015-022-10444-7
• A Stem Cell Roadmap of Ribosome Heterogeneity Reveals a Function for RPL10A in Mesoderm Production (Nature Communications) https://www.nature.com/articles/s41467-022-33263-3
• Human PSCs Determine the Competency of Cerebral Organoid Differentiation via FGF Signaling and Epigenetic Mechanisms (iScience) https://www.cell.com/action/showPdf?pii=S2589-0042%2822%2901412-2 
• Mouse Embryo Model Derived Exclusively from Embryonic Stem Cells Undergoes Neurulation and Heart Development (Cell Stem Cell) https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(22)00377-0
• Heparinized Gelatin-Based Hydrogels for Differentiation of Induced Pluripotent Stem Cells (Biomacromolecules) https://pubs.acs.org/doi/10.1021/acs.biomac.2c00585
• Acquisition and Maintenance of Pluripotency Are Influenced by Fibroblast Growth Factor, Leukemia Inhibitory Factor, and 2i in Bovine-Induced Pluripotent Stem Cells (Frontiers in Cell and Developmental Biology) https://www.stemcellsciencenews.com/newsletter/194131/
• Recent Advances for Using Human Induced-Pluripotent Stem Cells as Pain-in-a-Dish Models of Neuropathic Pain (Experimental Neurology) https://www.sciencedirect.com/science/article/pii/S0014488622002485?via%3Dihub
• Modeling Metabolic Diseases and Drug Response Using Stem Cells and Organoids (Nature Reviews Endocrinology) https://www.nature.com/articles/s41574-022-00733-z
• Harnessing Conserved Signaling and Metabolic Pathways to Enhance the Maturation of Functional Engineered Tissues (NPJ Regenerative Medicine) https://www.nature.com/articles/s41536-022-00246-3
• Spatial Molecular Anatomy of Germ Layers in the Gastrulating Cynomolgus Monkey Embryo (Cell Reports) https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01105-6
• Modeling Human Extraembryonic Mesoderm Cells Using Naive Pluripotent Stem Cells (Cell Stem Cell) https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(22)00337-X
• Systemic Proteomics and miRNA Profile Analysis of Exosomes Derived from Human Pluripotent Stem Cells (Stem Cell Research & Therapy) https://stemcellres.biomedcentral.com/articles/10.1186/s13287-022-03142-1
• Robust Genome Editing via modRNA-Based Cas9 or Base Editor in Human Pluripotent Stem Cells (Cell Reports Methods) https://www.cell.com/cell-reports-methods/fulltext/S2667-2375(22)00172-2
• Molecular Convergence between Down Syndrome and Fragile X Syndrome Identified Using Human Pluripotent Stem Cell Models (Cell Reports) https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01136-6
• Modeling Human Multi-Lineage Heart Field Development with Pluripotent Stem Cells (Cell Stem Cell) https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(22)00343-5 
• Generation of Human Induced Pluripotential Stem Cells from Individuals with Complex Heterozygous, Isogenic Corrected, and Homozygous Bloc1s1 Mutations (Stem Cell Research) https://www.sciencedirect.com/science/article/pii/S1873506122002549

August 2022

• DLL4 and VCAM1 Enhance the Emergence of T Cell–Competent Hematopoietic Progenitors from Human Pluripotent Stem Cells (Science Advances) https://www.science.org/doi/10.1126/sciadv.abn5522
• Repeated Intravenous Administration of hiPSC-MSCs Enhance the Efficacy of Cell-Based Therapy in Tissue Regeneration (Communications Biology) https://www.nature.com/articles/s42003-022-03833-8