Published: Jan. 26, 2017

Richard Johnson, MD

Richard Johnson, MD

On Friday, Jan. 27, the Distinguished Lecture Series will featureÌýRichard Johnson, MD. TheÌýlecture, titled "Climate Change and the Evolution of Humans," discusses a mutation in uric acid metabolism thatÌýlikely occurred in Europe as a survival advantage for apes livingÌýthere.

The mutation reportedlyÌýenhanced the ability of the apes to store fat and survive during theÌýperiod of progressive starvation.ÌýThis same mutation can be shown to markedly amplify the effectÌýof fructose to increaseÌýfat stores.Ìý

While this was a survival advantage for early apes, with the introduction of table sugar (fructose/glucose), the mutation markedly enhanced humans' ability to become fat and can be shown to have a role in the current diabetesÌýand obesity epidemic.Ìý

Johnson argues this case example shows how climate change has increased humanÌýrisk for obesity, diabetesÌýand kidneyÌýdisease today;Ìýhow it is being compounded by ongoing increases in temperatureÌýandÌýhow, equipped with this knowledge, humans can directly intervene toÌýnotÌýonly help the speciesÌýbutÌýother species whose survival is being challenged by changes in the environment.

Johnson is the Tomas Berl professor of medicine and department headÌýof the at the University of Å·ÃÀ¿Ú±¬ÊÓƵ Anschutz Medical Campus since 2008.

If you go

Who: Richard Johnson, MD
What: "Climate Change and the Evolution of Humans"
When: Friday, Jan. 27, 4 p.m.
Where: , room 338

He is a highly-cited scientist who has lectured in over 40 countries, has authored two booksÌý(The Sugar Fix, 2008,Ìýand the The Fat Switch, 2012)Ìýand whose research has been funded by the National Institutes of Health. Johnson's primary research interest has been on mechanisms causing kidney disease, but he also has performed research on mechanisms causing obesity, diabetesÌýand heart disease.ÌýHe has special interest in the potential role of sugar (especially fructose) and its byproductÌýuric acidÌýin driving metabolic and kidney disorders.

Most recently his work has shifted to how animals survive climate changeÌýand the potential role of heat stress and dehydration as a mechanism to cause chronic kidney disease. Johnson also has an active clinical practiceÌýand enjoys patient care.

The Distinguished Lecture Series, presented by theÌýCooperative Institute for Research in Environmental Sciences (CIRES), is designed to bring outstanding scientists who take imaginative positions on environmental issues and can establish enduring connections after their departure.