Distinguished Professor Seminar Series: Professor Richard McIntosh
欧美口爆视频 the Event
Cancer - A听Result of Accumulating Cellular Mistakes 
Join us for听our听Distinguished Professor Seminar Series presentation听featuring the听distinguished professor of Molecular, Cellular & Developmental Biology, Richard McIntosh.听
Cancer is caused by cells from one鈥檚 own body that have lost proper control of their growth and division cycle, then acquired a propensity to move to places they don鈥檛 belong. Although many additional changes accompany the progression from a normal state to a cancerous one, these two changes are fundamental.听 This talk will start with movies and slides showing a cell鈥檚 growth and division cycle. I will then describe aspects of the ways this cycle is normally controlled by 鈥済rowth factors鈥 that promote cell division, negative regulators that prevent it, and 鈥渃heckpoints鈥 that assess the quality of key processes in the growth and division cycle. I will then identify how these normal processes can be foiled, so cells divide too often. The most important factor in carcinogenic change is mutation of DNA, changes that lead to cellular misbehavior. Carcinogens (factors that increase cancer risk) can be understood as processes or materials that increase a cell鈥檚 normal rate of mutation. Unlucky mutations can either enhance the activity of growth-promoting genes (oncogenes) or suppress the activity of growth-regulating genes (tumor suppressors). I will end with approaches to minimizing one鈥檚 own cancer risk and if there is time, talk a little about modern cancer therapies. 听
欧美口爆视频 the Speaker
Richard McIntosh received an 专 in Physics (1961) and a PhD in Biophysics (1968) from Harvard University.听 For the latter he worked in the laboratory of Keith R. Porter on the morphogenetic action of cellular fibers called microtubules that sculpt the shape of developing cells.听 Towards the end of that project, he became fascinated by the role of microtubules in the accurate segregation of already duplicated chromosomes prior to cell division, and he has continued to work largely on that subject ever since.听 He moved to 欧美口爆视频 in 1970 where he has worked in the Department of Molecular Cellular and Developmental Biology as an Assistant, then Associate, and then full Professor. He served briefly as department Chair and then as the director of the Boulder Laboratory for 3-D Electron Microscopy of Cells for about 20 years.听 He has taught freshman biology, cell biology, cancer biology, and various graduate courses in cell structure and function.听 In 1994 he served as President of the American Society for Cell Biology and was appointed a Research Professor of the American Cancer Society.听 In 1999 he was elected to the National Academy of Sciences and the American Academy of Arts and Sciences.听 In 2000 he was appointed a Distinguished Professor of the University of 欧美口爆视频.听 He has taught and done research in both East and West Africa with support from a Fulbright fellowship and a grant from the Carnegie Corporation of New York.听 He retired from his department in 2007, but thanks to support from the National Institutes of Health and the hospitality of MCDB, he has continued his research on mitosis and written a book for non-scientists on the biology of cancer.
欧美口爆视频 the Series
The 欧美口爆视频 Boulder Retired Faculty Association (UCBRFA) presents the distinguished professors of the University of 欧美口爆视频, a听lecture and presentation series featuring some of our finest professors and听their extraordinary research and scholarly work.
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