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Publications from BioServe-Supported Spaceflight Experiments and Ground Studies

(listed alphabetically, grouped by the year published) 

2015

Countryman, S. M., Stumpe, M. C., Crow, S. P., Adler, F. R., Greene, M. J., Vonshak, M., & Gordon, D. M. (2015). Collective search by ants in microgravity. Frontiers in Ecology and Evolution, 3, 25.

Hwang S, Crucian BE, Sams CF, Actor JK.  Post-spaceflight (STS-135) mouse splenocytes demonstrate altered activation properties and surface molecule expression. PLOS ONE. 2015 May 13; 10(5): e0124380. DOI: 10.1371/journal.pone.0124380. PMID: 25970640.

Nislow, C, Lee, AY, Allen, PL, Giaever, G, Smith, A, Gebbia, M, Stodieck, LS, Hammond, JS, Birdsall, HH and Hammond, TG. (2015) “Genes required for survival in microgravity revealed by genome-wide yeast deletion collections cultured during spaceflight.” BioMed Research Int, ID 976458, 10 pgs.

Philippou A, Minozzo FC, Spinazzola JM, Smith LR, Lei H, Rassier DE, Barton ER.  Masticatory muscles of mouse do not undergo atrophy in space. FASEB: Federation of American Societies for Experimental Biology Journal. 2015; epub. DOI: 10.1096/fj.14-267336. PMID: 25795455.

Zea, L., Phenotypic and Gene Expression Responses of E. coli  to Antibiotics during Spaceflight, Ph.D. Thesis, University of ŷ���ڱ���Ƶ, Boulder, CO, 2015

2014

Ishihara A¹, Nagatomo F, Terada M, Fujino H, Kondo H, Ishioka N. (2014) “Effects of microgravity on the mouse triceps brachii muscle.” Muscle Nerve. Oct 12. doi: 10.1002/mus.24491.

Latchney, S.E., Rivera, P.D., Mao, X.W., Ferguson, V.L., Bateman, T.A., Stodieck, L.S., Nelson, G.A. and Eisch, A.J. (2014) “The effect of spaceflight on mouse olfactory bulb volume, neurogenesis and cell death indicates the protective effect of novel environment”, J Appl Phsiol, epub 17 April.

Mao, XW, Pecaut, MJ, Ferguson, VL, Bateman TA, Bouxsein, ML and Gridley, DS. (2014)  “Biological and metabolic response in STS-135 space-flown mouse skin.” Free Radic Res.  epub 6 May.

2013

Behnke BJ¹, Stabley JN, McCullough DJ, Davis RT 3rd, Dominguez JM 2nd, Muller-Delp JM, Delp MD. (2013) “Effects of spaceflight and ground recovery on mesenteric artery and vein constrictor properties in mice.” FASEB J. Jan;27(1):399-409.

Chapes SK, Ortega MT. (2013) “Understanding macrophage differentiation during space flight: The importance of ground-based experiments before space flight.” Recent Pat Space Technol. 2013 Jun 1;3(1):40-47.

Crabbé A, Nielsen-Preiss SM, Woolley CM, Barrila J, Buchanan K, McCracken J, Inglis DO, Searles SC, Nelman-Gonzalez MA, Ott CM, Wilson JW, Pierson DL, Stefanyshyn-Piper HM, Hyman LE, Nickerson CA. (2013) “Spaceflight enhances cell aggregation and random budding in Candida albicans” PLoS One. 2013 Dec 4;8(12):e80677.

Gridley, DS, Mao, XW, Stodieck, LS, Ferguson, VL, Bateman, TA, Moldovan, M, Cunningham, CE, Jones, Slater, JM and Pecaut, MJ. (2013)  “Changes in mouse thymus and spleen after return on STS-135 mission in space.”  PLoS One, Sep 19;8(9):e75097.

Hammond, TG, Stodieck, LS, Birdsall, HH, Becker, JL, Koenig, P, Hammond, JS, Gunter, MA and Allen, PL. (2013) “Effects of microgravity on the virulence of Listeria monocytogenes, Enterococcus faecalis, Candida albicans, and Methicillin-Resistant Staphylococcus aureus”, Astrobiology, 13(11)1081-1090.

Hammond, TG, Stodieck, LS, Birdsall, HH Becker, JL, Koenig, P, Hammond, JS, Gunter, MA and Allen, PL (2013) “Effects of microgravity on the virulence of Salmonella Toward Caenorhabditis elegans,” New Space, 1(3):123-131.

Hanson, AM, Harrison, BC, Young, MH, Stodieck, LS and Ferguson, VL. (2013) “Longitudinal characterization of functional, morphologic and biochemical adaptations in mouse skeletal muscle with hindlimb suspension.” Muscle Nerve, 48(3):393-402.

Kim W, Tengra FK, Shong J, Marchand N, Chan HK, Young Z, Pangule RC, Parra M, Dordick JS, Plawsky JL, Collins CH.(2013) “Effect of spaceflight on Pseudomonas aeruginosa final cell density is modulated by nutrient and oxygen availability.” BMC Microbiol. 2013 Nov 6;13:241.

Kim, W.S., Tengra, F.K., Young, Z., Shong, J., Marchand, N., Chan, H.K., Pangule, R.C., Parra, M., Dordick, J.S., Plawsky, J.L., and Collins, C.H. (2013) “Spaceflight promotes biofilm formation by Pseudomonas aeruginosa.” PLoS One 8, e62437

Mao, XW, Pecaut, MJ, Stodieck, LS, Ferguson, VL, Bateman, TA, Bouxsein, M, Jones, TA, Moldovan, M, Cuinningham, CE, Chieu, J and Gridley, DS “Spaceflight environment induces mitochondrial oxidative damage in ocular tissue, Radiation Research, 2013, 180:340-350.

Vendrame, W. A., & Pinares, A. (2013). Characterizing parameters of Jatropha curcas cell cultures for microgravity studies. Advances in Space Research, 51(11), 2069-2074

Sung M¹, Li J, Spieker AJ, Spatz J, Ellman R, Ferguson VL, Bateman TA, Rosen GD, Bouxsein M Rutkove SB. (2013) “Spaceflight and hind limb unloading induce similar changes in electrical impedance characteristics of mouse gastrocnemius muscle.” J Musculoskelet Neuronal Interact Dec;13(4):405-11.

2012

Dabertrand F, Porte Y, Macrez N, Morel J.  Spaceflight regulates ryanodine receptor subtype 1 in portal vein myocytes in the opposite way of hypertension.. Journal of Applied Physiology. 2012 February 1; 112(3): 471-480. DOI: 10.1152/japplphysiol.00733.2011.

Gridley DS, Pecaut MJ, Green LM, Hermann EC, Bianski B, Slater JM, Stodieck LS, Ferguson VL and Sandberg LB.  (2012) “Effects of Space Flight on the Expression of Liver Proteins in the Mouse.” J Proteomics Bioinform, 5(10):256-261.

Klaus D.M, Fanchiang C and Ocampo RP (2012) “Perspectives on Spacecraft Human-Rating.”  AIAA-2012-3419.

Metts JG and Klaus DM. (2012) “First-order feasibility analysis of a space suit radiator concept based on estimation of water mass sublimation using Apollo mission data.” Advances in Space Research 49(1): 204-212.

Moreno NP, Vogt GL, Denk JP, Countryman S, Stodieck LS, Thomson WA.  Butterflies and Spiders in Space: Space Life Science Investigations for the Classroom. Gravitational and Space Biology. 2012; 26(1): 77 - 87.

Oczypok EA, Etherridge T, Freeman J, Stodieck L, Johnsen R, Bailie D, Szewczyk NJ. (2012) “Remote automated multi-generational growth and observation of an animal in low Earth orbit.”  J R Soc Interface, 9(68):596-599

Stodieck LS, Greybeck BJ, Cannon CMA, Hanson AM, Young MH, Simske SJ, Ferguson, VL. (2012) “In vivo measurement of hindlimb neuromuscular function in mice” Muscle and Nerve, 45(4):536-43.

2011

Cartwright JH,  Escribano B, Sainz-Díaz CI, Stodieck LS. (2011) “Chemical-garden formation, morphology, and composition. II. Chemical gardens in microgravity.” Langmuir. Apr 5; 27(7):3294-300.

Crabbé A¹, Schurr MJ, Monsieurs P, Morici L, Schurr J, Wilson JW, Ott CM, Tsaprailis G, Pierson DL, Stefanyshyn-Piper H, Nickerson CA. (2011) “Transcriptional and proteomic responses of Pseudomonas aeruginosa PAO1 to spaceflight conditions involve Hfq regulation and reveal a role for oxygen,” Appl Environ Microbiol. 2011 Feb;77(4):1221-30.

Kobrick RL, Klaus DM, and Street KW. (2011) “Developing  Abrasion Test Standards for Evaluating Lunar Construction Materials.” SAE Int. J. Aerospace 4(1):160-171.

Klaus DM. (2011) “Microgravity” in Encyclopedia of Astrobiology, Part 13/M, Muriel Gargaud (ed.), Springer-Verlag Berlin Heidelberg, pp. 1054-1055.

Metts JG, Nabity JA and Klaus DM. (2011) “Theoretical Performance Analysis of Electrochromic Radiators for Space Suit Thermal Control.” Advances in Space Research 47(7): 1256-1264.

Kobrick RL, Klaus DM and Street KW Jr. (2011) “Validation of proposed metrics for two-body abrasion scratch test analysis standards.” WEAR (issue 11-12) 270: 815–822.

Kobrick RL, Klaus DM and Street KW, Jr. (2011) “Standardization of a volumetric displacement measurement for two-body abrasion scratch test data analysis.” WEAR (issue 9-10) 270: 650-657.

Kobrick RL, Klaus DM and Street KW Jr. (2011) “Defining an abrasion index for lunar surface systems as a function of dust interaction modes and variable concentration zones.” Planetary and Space Science 59: 1749–1757.

Lloyd SA, Simske SJ, Bogren LK, Olesiak SE, Bateman TA and Ferguson VL. (2011) “Effects of combined insulin-like growth factor 1 and macrophage colony-stimulating factor on the skeletal properties of mice.”  In Vivo. May-Jun; 25(3):297-305.

Searles SC, Woolley CM, Petersen RA, Hyman LE, Nielsen-Preiss SM. (2011) “Modeled microgravity increases filamentation, biofilm formation, phenotypic switching, and antimicrobial resistance in Candida albicans.” Astrobiology. 2011 Oct;11(8):825-36.

2010

Allen DL, Greybeck BJ, Hanson AM, Cleary AS and Lindsay SF.  (2010) “Skeletal muscle expression of bone morphogenetic protein-1 and tolloid-like-1 extracellular proteases in different fiber types and in response to unloading, food deprivation and differentiation.” J Physiol Sci, 60(5): p. 343-352.

Gifford KK, Williams S, Maiorani L, Marshall B and Sotola M. (2010) “BioNet Middleware and Software framework in Support of Space Operations.” AIAA SpaceOps AIAA-2010-2251.

Hanson AM, Stodieck LS, Cannon CM, Simske SJ, Ferguson VL. (2010) “Seven days of muscle re-loading and voluntary wheel running following hindlimb suspension in mice restores running performance, muscle morphology and metrics of fatigue but not muscle strength.” J Muscle Res Cell Motil, 31(2): p. 141-153.

Horneck G, Mancinelli R. and Klaus D. (2010) “Space Microbiology.” Microbiology and Molecular Biology Reviews 74(1): 121-156.

Jenkins A, Kuzminsky S, Gifford KK, Pitts RL and Nichols K. (2010) “Delay/Disruption-Tolerant Networking: Flight Test Results from the International Space Station.” IEEE AerospaceConference, 5446948. 

Kearney M, Kiely A, Yeh, P, Gerner J, Calzolari GP, Gifford K, and Merri M. (2010) “CCSDS – Advancing Spaceflight Technology for International Collaboration.” 61^st International Astronautical Congress, Prague, CZ, IAC-10-D9.2.8, September.

Khairul-Bariah AAN, Then SM, Rageshwary R, Fazlina N, Wan-Zurinah WN, Roslan H, Klaus DM, Stodieck LS and Jamal R. (2010) “Changes in Gene Expression of HepG2 Cells Exposed to Microgravity.” Gravitational and Space Biology Bulletin 23(2): 91-92.

Lebsack TW, Fa V, Woods CC, Gruener R, Manziello AM, Pecaut MJ, Gridley DS, Stodieck LS, Ferguson VL, Deluca D.  (2010) “Microarray analysis of spaceflown murine thymus tissue reveals changes in gene expression regulating stress and glucocorticoid receptors.” J Cell Biochem. May 15;110 (2):372-81.

Pitts R, Nichols K, Holbrook M, Gifford KK, Kuzminsky S and Jenkins A. (2010)  “DTN Implementation and Utilization Options on the International Space Station.” AIAA SpaceOps, AIAA-2010-2173.

Talbot NC, Caperna TJ, Blomberg L, Graninger PG, Stodieck LS (2010) “The effects of space flight and microgravity on the growth and differentiation of PICM-19 pig liver stem cells.” In Vitro Cell Dev Biol Anim. 46(6):502-15.

Thomas EA, Weislogel MM, Klaus DM. (2010) “Design Considerations for Sustainable Spacecraft Water Management Systems.” Advances in Space Research 46: 761-767.

Tian J, Pecaut MJ, Slater JM, Gridley DS. (2010) “Spaceflight modulates expression of extracellular matrix, adhesion, and profibrotic molecules in mouse lung.”  J Appl Physiol Jan;108(1):162-71.

2009

Allen DL, Bandstra ER, Harrison BC, Thorng S, Stodieck LS, Kostenuik PJ, Morony S, Lacey DL, Hammond TG, Leinwand LL, Argraves WS, Bateman TA, Barth JL (2009) “Effects of Spaceflight on murine skeletal muscle gene expression”, J Appl Physiol, Feb;106(2):582-95

Baqai FP, Gridley DS, Slater JM, Luo-Owen X, Stodieck LS, Ferguson V, Chapes SK, Pecaut MJ (2009)“Effects of spaceflight on innate immune function and antioxidant gene expression”, J Appl Physiol, Jun;106(6):1935-42.

Czupalla, M., Hager, P., Hein, A., Dirlich, T., Zhukov, A., Pfeiffer, M and Klaus, D. (2009) “Model Confidence Level - A Systematic Metric for Development of a Virtual Space Habitat” SAE Technical Paper 2009-01-0208

Gridley DS, Slater JM, Luo-Owen X, Rizvi A, Chapes SK, Stodieck LS, Ferguson VL, Pecaut MJ, (2009) “Spaceflight effects on T lymphocyte distribution, function and gene expression”, J Appl Physiol, Jan;106(1):194-202.

Klaus, D.M. and Higdon, K.P. (2009) “Academic Principles of Human Space Habitat Design”, SAE Technical Paper 2009-01-2547 Kobrick, R.L. and Klaus, D.M. (2009) “Developing Abrasion Test Standards for Evaluating Lunar Construction Materials” SAE Technical Paper 2009-01-2377

Leidich, J., Thomas, E.A. and Klaus, D.M. (2009) “A Novel Testing Protocol for Evaluating Particle Behavior in Fluid Flow Under Simulated Reduced Gravity Conditions” SAE Technical Paper 2009-01-2359

Metts, J.G. and Klaus, D.M. (2009) “Conceptual Analysis of Electrochromic Radiators for Space Suits” SAE Technical Paper 2009-01-2570

Ortega MT, Pecaut MJ, Gridley DS, Stodieck LS, Ferguson VL, Chapes, SK (2009) “Shifts in Bone Marrow Cell Phenotypes Caused by Space Flight”, J Appl Phsiol, 106(2):548-55.

Seelig, H-D., Hoehn, A., Stodieck, L.S., Klaus, D.M., Adams, W.W. and Emery, W.J. (2009) “Plant water parameters and the remote sensing R1300/R1450 leaf water index: controlled condition dynamics during the development of water deficit stress” Irrigation Science 27:357–365

Seelig, H-D, Hoehn, A, Stodieck, LS, Klaus, DM, Adams III, WW and Emery, WJ (2009) “Plant water parameters and the remote sensing R1300/R1450 leaf water index: controlled condition dynamics during the development of water deficit stress”, Irrigation Sci, 27(5):357-365.

Thomas, E.A., Leidich, J. and Klaus, D.M. (2009) “A Sustainable Regolith-Based Water Recovery Concept for the Lunar Outpost” SAE Technical Paper 2009-01-2503

2008

Allen DL, Bandstra ER, Harrison BC, Thorng S, Stodieck LS, Kostenuik PJ, Morony S, Lacey DL, Hammond TG, Leinwand LL, Argraves WS, Bateman TA, Barth JL. “Effects of Spaceflight on murine skeletal muscle gene expression,” J Appl Physiol. 2008 Dec 12. [Epub ahead of print]

Benoit, M.R., Brown, R.B., and Todd, P., Nelson, E, and Klaus, D.M. “Buoyant plumes from solute gradients generated by non-motile,” Escherichia coli. Physical Biology 2008, 5: 046007, 10pp (doi:10.1088/1478-3975/5/4/046007)

Coleman, C. B., Allen, P. L., Rupert, M., Goulart, C., Hoehn, A., Stodieck, L. S., & Hammond, T. G. (2008). Novel Sfp1 transcriptional regulation of Saccharomyces cerevisiae gene expression changes during spaceflight. Astrobiology, 8(6), 1071-1078.

Gridley DS, Slater JM, Luo-Owen X, Rizvi A, Chapes SK, Stodieck LS, Ferguson VL, Pecaut MJ. “Spaceflight Effects on T Lymphocyte Distribution, Function and Gene Expression,” J Appl Physiol. 2008 Nov 6. [Epub ahead of print]

Klaus, D. and Morrow, R. “Life Sciences (Air and Space Year in Review)” Aerospace America 2008, 12: 88-89 Ortega MT, Pecaut MJ, Gridley DS, Stodieck LS, Ferguson VL, Chapes SK. “Shifts in Bone Marrow Cell Phenotypes Caused by Space Flight,” J Appl Physiol. 2008 Dec 4. [Epub ahead of print]

Seelig H-D, Hoehn A, Stodieck LS, Klaus DM, Adams WW III and Emery WJ. “The assessment of leaf water content using leaf reflectance ratios in the visible,
near-, and short-wave infrared”, Int. J. of Remote Sensing 2008
29(13):3701-3713.

Seelig H-D, Hoehn A, Stodieck LS, Klaus DM, Admas WW III and Emery WJ. “Relations of remote sensing leaf water indices to leaf water thickness in cowpea, bean, and sugarbeet plants,” Remote Sensing of Environment 2008 112: 445-455.

Seelig ,H-D., Adams, W.W., Hoehn, A., Stodieck, L.S., Klaus, D.M. and Emery, W. J. “Extraneous variables and their influence on reflectance-based measurements of leaf water content.” Irrigation Science 2008, 26: 407–414

Wilson JW, Ott CM, Quick L, Davis R, zu Bentrup KH, Crabbé A, Richter E, Sarker S, Barrila J, Porwollik S, Cheng P, McClelland M, Tsaprailis G, Radabaugh T, Hunt A, Shah M, Nelman-Gonzalez M, Hing S, Parra M, Dumars P, Norwood K, Bober R, Devich J, Ruggles A, CdeBaca A, Narayan S, Benjamin J, Goulart C, Rupert M, Catella L, Schurr MJ, Buchanan K, Morici L, McCrac ken J, Porter MD, Pierson DL, Smith SM, Mergeay M, Leys N, Stefanyshyn-Piper HM, Gorie D, Nickerson CA. “Media ion composition controls regulatory and virulence response of Salmonella in spaceflight.” PLoS ONE. 2008; 3(12):e3923. Epub 2008 Dec 12.

2007

Benoit, M. and Klaus, D.M. (2007) “Microgravity, Bacteria, and the Influence of Motility” Advances in Space Research, 39(7): 1225-1232

Cavanagh, P. R., & Rice, A. J. (2007). Bone loss during spaceflight: etiology, countermeasures, and implications for bone health on Earth. Cleveland Clinic Press.

Clawson, J. (2007) Title: Durability and design approaches in the use of flexible transparent polymer films for a Mars greenhouse application. Doctoral Thesis, University of ŷ���ڱ���Ƶ

Geschwill, L., Massey, D., Kobrick, R., Kanner, L. and Klaus, D (2007) Educational Opportunities Supporting the Development of a Full-Scale Mockup of the New Lunar Lander at the University Level: A Case Study. AIAA Region V Student Paper Conference and Competition, US Air Force Academy, ŷ���ڱ���Ƶ Springs, CO, April 2007 (received 3rd Place Award, Team Category)

Gifford, K.K., Braham, S., (2007) "Wireless network systems to support NASA's Exploration Vision" AIAA InfoTech@Aerospace 2007, Paper # AIAA-2007-2927, Rohnert Part, CA.

Hoehn, A., Countryman, S., Freeman, J., Gifford, K., Goulart, C., Kalinowski, W., Koenig, P., Kusminski, S., Williams, S., and Stodieck, L. (2007) “Science Research and Education Modules for the CGBA Spaceflight Incubator” SAE Technical Paper 2007-01-3188.

Hoehn, A., Lynch, K., Clawson, J., Kapit, J., Young, S., Kounaves, S. and Brown, I. (2007) “Microbial Detection Array (MDA), a Novel Instrument for Unambiguous Detection of Microbial Metabolic Activity” SAE Technical Paper in Astrobiology Applications 2007-01-3190.

Johanson, K., Allen, P, Gonzalez-Villalobos, R., Nesbit, J., Nickerson, C., Höner zu Bentrup, K., Wilson, J., Ramamurthy, R., D’Elia, R., Muse, K., Hammond, J., Freeman, J., Stodieck, L. and Hammond, T. (2007) “Haploid deletion strains of Saccharomyces cerevisiae that determine survival during space flight” Acta Astronautica, 60(4-7):460-471

Klaus, D. (2007) Life Sciences (Air and Space Year in Review) Aerospace America 12: 87

Klaus, D.M., Metts, J., Kobrick, R., Mesloh, M., Monk, T., Gauthier, E., Eberhart, K., Baca, D., Wright, C., Gustafson, A., Oryshchyn, L. and Massey, D. (2007) “Space Suit Concepts and Vehicle Interfaces for the Constellation Program” SAE Technical Paper 2007-01-3088

Kobrick, R.L., and D.B. Spencer (2007) "Optimizing Trajectories for Suborbital Human Spaceflight" Journal of Spacecraft and Rockets, Vol. 44, No. 2

Kounaves, S. P., Brown, I. I., Galindo, C. , Hoehn, A., Kapit, J., Lynch, K., McKay, D., Sarkisova, S. and Young, S. (2007) “Detection of Microbial Life in Soil Based on Minimal Assumptions Using Measurements of Physical and Chemical Changes Induced by Growth” 7th International Conference on Mars” Pasadena, CA.

Lee, J.S., Klaus, D.M., Maness, P.C. and Spear, J.R. (2007) The Effect of Butyrate Concentration on Hydrogen Production via Photofermentation for use in a Martian Habitat Resource Recovery Process. International Journal of Hydrogen Energy 32 (15): 3301– 3307

Russell, J.F. and Klaus, D.M. (2007) “Maintenance, Reliability and Policies for Spacecraft Life Support Systems on Orbital Space Stations” Reliability, Engineering and Systems Safety 92(6): 808-820.

Wilson JW, Ott CM, Honer zu Bentrup K, Ramamurthy R, Quick L, Porwollik S, Cheng P, McClelland M, Tsaprailis G, Radabaugh T, Hunt A, Fernandez D, Richter E, Shah M, Kilcoyne M, Joshi L, Nelman-Gonzalez MA, Hing SM, Parra MP, Dumars P, Norwood KL, Bober R, Devich J, Ruggles AD, Goulart C, Rupert M, Stodieck LS, Stafford P, Catella LA, Schurr MJ, Buchanan K, Morici L, McCracken J, Allen PL, Baker-Coleman C, Hammond TG, Vogel J, Nelson R, Pierson DL, Stefanyshyn-Piper HM, Nickerson CA.  Space flight alters bacterial gene expression and virulence and reveals a role for global regulator Hfq. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(41): 16299-16304. DOI: 10.1073/pnas.0707155104. PMID: 17901201.

2006

Aponte, V. M., Finch, D. S., and Klaus, D. M. (2006) Considerations for non-invasive in-flight monitoring of astronaut immune status with potential use of MEMS and NEMS devices. Life Sciences Journal 79(14): 1317-1333

Benoit, M.R., Li, W., Stodieck, L.S., Lam, K.S., Winther, C.L., Roane, T.M. and Klaus, D.M. (2006) Microbial Antibiotic Production Aboard the International Space Station. Applied Microbiology and Biotechnology, 70(4): 403-411

Chappell, S.P. and Klaus, D.M. (2006) Enhanced simulation of partial gravity for extravehicular activity. Journal of Human Performance in Extreme Environments 9(1)

Chappell, S.P., Klaus, D.M. and Parazynski, S.E. (2006) Access Systems for Partial Gravity Exploration & Rescue: Engineering Analysis & Design, SAE Technical Paper 2006-01-2291

Gifford, K.K., Kuzminsky, S., Williams, S., and Saiz, J., "BioNet: A developer-centric middleware architecture for heterogeneous devices and protocols" IEEE Wireless Communications and Networking Conference, Las Vegas, NV, April, 2006.

Hanson AM, Young MH, Stodieck LS, Ferguson VL (2006) "Longitudinal Hindlimb Suspension Study Reveals Physical, Functional and Biochemical Changes in Mouse Skeletal Muscle." Poster Presentation, Annual Meeting of the American Society for Gravitational and Space Biology, Arlington, VA Gravitational and Space Biology, 20(1):16

Hatfield, T., Klaus, D. and Simske, S. (2006) Ultrasonic 360º Cross Section Scanning Methodology for Monitoring Bone and Muscles Areas During Space Flight. Microgravity Science and Technology XVIII(1): 15-21

Hoehn, A., J.B. Freeman, P. Koenig, L.S. Stodieck, M. Vellone, S. Williams, J. deLuis, W. Feenstra, J.C. Parrish, S. Pretorius, L. Sun, S. Dyble, N. Searby, D. Vandendriesche (2006): " Single Loop for Cell Culture (SLCC) – Development and Spaceflight Qualification of a Perfusion Cell Culture System", SAE-paper 2006-01-2212, International Conference Environmental Systems (ICES), July 2006, Norfolk, Virginia.

Heyenga, A.G., C. Blackford, R.N. Bowman, M.H. Kliss, "Optimization of Extraterrestrial Plant Biology Research Through the Use of Standardized Plant Cultivation and Analysis Technologies", SAE-paper 2006-01-2213, International Conference Environmental Systems (ICES), July 2006, Norfolk, Virginia.

Klaus, D.M. and Howard, H.N. (2006) Antibiotic Efficacy and Microbial Virulence during Space Flight. Trends in Biotechnology 24(3):131-6

Klaus, D., Bamsey, M., Schuller, M., Godard, O., Little, F. and Askew, R. (2006) Defining Space Suit Operational Requirements for Lunar and Mars Missions and Assessing Alternative Architectures. SAE Technical Paper 2006-01-2290

Kobrick, R.L., Battler, M. M., Persaud, R., Wilkinson, N. (2006) “Training a crew for human exploration by using Mars analogue research stations” 57th International Astronautical Congress. Space Education and Outreach Symposium, Space Exploration Education session, IAC-06-E1.5.04, Valencia, Spain.

Kobrick, R.L., Dara, S., Burley, J., and Gill, S. (2006): “A New Countermeasure Device For Long Duration Space Flights” Acta Astronautica, 58: 523-536.

Kounaves, S.P., Lynch, K.L., Brown, I. I., Hoehn, A., McKay, D.S., Young S.M.M. (2006) Microbial Detection Array. Astrobiology 6(1): 282 [Epub DOI:10.1089/ast.2006.6.247]

Russell, J., Klaus, D. and Mosher, T. (2006) Applying Analysis of International Space Station Crew-Time Utilization to Mission Design. J Spacecraft and Rockets 43(1): 130-136.

Plancke, P., Saiz, J., Hernandez-Velasco, I., Gifford, K.K., and Carron, C., "Wireless Communications and Interfaces onboard Spacecraft" AIAA SpaceOps 2006 Conference, Rome, Italy, June, 2006.

Schuller, M., Klaus, D., Lalk, T., Wiseman, L., Thomas, G., Little, F., Godard, O., Kobrick, R., Abdel-Fattah, S., Rouen, M. and Askew, R. (2006) Innovative Schematic Concept Analysis for a Space Suit Portable Life Support Subsystem, SAE Technical Paper 2006-01-2201

Stroud, K.J. and Klaus, D.M. (2006) Spacecraft Design Considerations for Piloted Reentry and Landing. J. British Interplanetary Society 59(12): 426-442

2005

Bandstra ER, Barth JL, Argraves WS, Harrison BC, Bateman TA (2005) “Microarray Analysis of Spaceflown Mouse Gastrocnemius.” In Bone Loss during Spaceflight Symposium Proceedings, Cleveland Clinic, Cleveland, OH.

Bateman, TA (2005) “Spaceflight as a biomedical test-bed for bone loss countermeasures and candidate osteoporosis therapies.” In IAA Humans in Space.

Benoit, M.R. (2005) Responses, Applications, and Analysis of Microgravity Effects on Bacteria. Doctoral Thesis, University of ŷ���ڱ���Ƶ, Boulder

Benoit, M.R. and Klaus, D.M. (2005). “Can genetically modified Escherichia coli with neutral buoyancy induced by gas-vesicles be used as an alternative method to clinorotation for microgravity studies?” Microbiology 151(1): 69-74.

Benoit, M.R., Nelson, E.S. and Klaus, D.M. (2005) “Mathematical Analysis and Numerical Modeling of Buoyant Flow from Solute Gradients around Growing Escherichia coli Cells” (abstract) Gravitational and Space Biology Bulletin 19(1): p. 21 and (poster) ASGSB 21st Annual Meeting, Reno, NV

Benoit, M. R., Nelson, E. S., and Klaus, D. M. (2005) “Numerical model simulations of buoyant plumes resulting from solute gradients around metabolizing bacteria.” In Proceedings of the COMSOL Multiphysics™ Conference, Cambridge, MA, October 23-25, pp. 63-69.

Cannon, C.M., Dieter-Seelig, H., Stodieck, L.S., Hanson, A.M., Simske, S.J., Ferguson, V. L. (2005) "A novel combination of methods to assess sarcopenia and muscle performance in mice." Biomed Scie Instrum. 41: 116-121.

Clawson, J. M. and A. Hoehn (2005). “Stress-Accelerated Photodegradation of Space-Rated Flexible Transparent Films Exposed to Mars Surface UV.” SAE-paper: 2005-01-2775, In International Conference Environmental Systems (ICES) Proceedings, Rome, Italy.

Clawson, J. M. and A. Hoehn (2005). “Global Estimates of the Photosynthetically Active Radiation at the Mars Surface.” SAE-paper: 2005-01-2813 In International Conference Environmental Systems (ICES) Proceedings, Rome, Italy.

Clawson, J. M., A. Hoehn, et al. (2005). Inflatable Transparent Structures for Mars Greenhouse Applications. SAE -paper: 2005-01-2846, In International Conference Environmental Systems (ICES) Proceedings, Rome, Italy.

Gifford, K., Kuzminsky, S. and Williams, S. (2005) "An Integrated Architecture for Advanced Environmental and Physiological Monitoring." SAE Paper 2005-01-2874 In International Conference on Environmental Systems (ICES) Proceedings, Rome, Italy.

Goulart, Carla V., Woodard, Sherry, and Campbell, Kimberly. (2005) “STARS™ (Science Technology and Research Students): A Hands-on, Interactive, Scientific and Cultural Exchange Lesson.” SAE-paper 2005- 01-3102, In International Conference Environmental Systems (ICES) Proceedings, Rome, Italy.

Hamilton, SA, Gridley, DS, Pecaut, MJ, Bateman, TA (2005) “Osteoblast and Osteoclast Response to Radiation Induced Bone Loss.” In Radiation Research Society Annual Meeting Proceedings. Hamilton, SA, Gridley, DS, Pecaut, MJ, Bateman, TA (2005) “Radiation affects the microarchitecture of bone.” In 27th American Society for Bone and Mineral Research Annual Meeting Proceedings.

Hamilton, SA, Gridley, DS, Pecaut, MJ, and Bateman, TA (2005) “The Effects of Radiation on Murine Bone Loss.” In Proceedings of the 15th Human in Space Symposium, Graz, International Academy of Astronautics 15:85.

Hamilton, SA, Pecaut, MJ, Gridley, DS, Harris, LG, and Howard, SH (2005) “Low-dose ionizing radiation induces murine bone loss.” In Bone Loss during Spaceflight Symposium Proceedings, Cleveland Clinic, Cleveland, OH.

Hamilton, SA, Gridley, DS, Pecaut, MJ, and Bateman, TA (2005) “Osteoblast and Osteoclast Response to Radiation Induced Bone Loss.” In Radiation Research Society Annual Meeting Proceedings.

Hanson, A.M., Ferguson, V.L, Simske, S.J., Cannon, C.M., Stodieck, L.S. (2005) “Comparison of tail-suspension and sciatic nerve crush on the musculoskeletal system in young-adult mice.” Biomed Sci Instrum. 41:92-6, 2.

Hanson, A.M., Simske, S.J, Stodieck, L.S, Cannon, C.A., Ferguson, V.L. (2005) “Investigating Voluntary Wheel Running as a Recovery Method for Tail Suspension Induced Sarcopenia” Gravitational and Space Biology Bulletin 19(1): p. 10 and (poster) ASGSB 21st Annual Meeting, Reno, NV

Heÿenga, G., Kliss, M., and Blackford, C. (2005): "The Performance of a Miniature Plant Cultivation System Designed for Space Flight Application", SAE-paper: 2005-01-2844. In International Conference Environmental Systems (ICES) Proceedings, Rome, Italy.

Hoehn, A., Clawson, J.M., Higgins, C., Jairala, J., Journey-Kahler, P., Lee, J., and Stodieck, L. (2005): “Carbon Dioxide Scrubbers for Controlling the Gaseous Composition of Spaceflight Plant Growth Chambers – Design Trades and Test Results.” SAE-paper: 2005-01-2954, In International Conference Environmental Systems (ICES) Proceedings, Rome, Italy.

Hoehn, A., Clawson, J.M., Freeman, J.B., and Stodieck, L.S. (2005): "Temperature and Humidity Control Capabilities and Limitations of a Spaceflight Plant Growth Chamber." SAE-paper: 2005-01-2845. In International Conference Environmental Systems (ICES) Proceedings, Rome, Italy.

Howard, H.N. and Klaus, D.M. (2005) “Containment Geometry Considerations for Space Flight and Simulated Microgravity Microbiology Experiments” (abstract) Gravitational and Space Biology Bulletin 19(1): p. 11 and (poster) ASGSB 21st Annual Meeting, Reno, NV

Howard, SH, Hamilton, SA, Harris, LG, Pecaut, MJ, Gridley, DS, Obenaus, A, and Bateman, TA (2005) “Heavy ion iron radiation causes bone loss in rats.” In Bone Loss during Spaceflight Symposium Proceedings, Cleveland Clinic, Cleveland, OH.

Klaus, D. M., Adams, A. C., Bamsey, M., Cragg, M., Ellis, T., Higgins, C. D., Howard, H. N., Jairala, J., Kelly, E. A., Krauser, W. R., McFarland, S. M., and Vellone, M. M. (2005): "Spacecraft Life Support System Design Guidelines for Human Exploration of the Moon and Mars", SAE-paper: 2005-01-3008. In International Conference Environmental Systems (ICES) Proceedings, Rome, Italy.

Lau, AG, Yuan, YY, Kostenuik, PJ, Morony, S, Adamu, S, Asuncion, F, and Bateman, TA (2005) “RANKL Has Detrimental Effects on Cortical and Trabecular Bone Volume, Mineralization, and Bone Strength in Mice.” In Bone Loss during Spaceflight Symposium Proceedings, Cleveland Clinic, Cleveland, OH.

Lloyd, SAJ, Cheluvaraju, C, Hamilton, SA, and Bateman, TA. (2005) “Determination of Minimum, Efficacious Comparable Doses of Zoledronate and Osteoprotegerin: Maximizing Bone Mass and Turnover.” In Annual Meeting of the American Society of Gravitational and Space Biology Proceedings.

Miesse, AM and Bateman, TA (2005) “Gender Response to Regenerative Nerve Damage-Induced Bone Loss.” In Bone Loss during Spaceflight Symposium Proceedings, Cleveland Clinic, Cleveland, OH.

Miesse, AM and Bateman, TA (2005) “Gender Response to Regenerative Nerve Damage-Induced Bone Loss.” In 27th American Society for Bone and Mineral Research Annual Meeting Proceeedings.

Mohr, KE, Recknor, CP, Recknor, JC, and Bateman, TA (2005) “Retrospective analysis of teriparatide as a therapy for osteoporosis.” In Bone Loss during Spaceflight Symposium Proceedings, Cleveland Clinic, Cleveland, OH.

Russell, J.F. (2005) Expanded Life-Cycle Analysis to Optimize Spacecraft Life Support System Design. Doctoral Thesis, University of ŷ���ڱ���Ƶ, Boulder Russell, J.F. and Klaus, D.M. (2005) “Anticipated Extravehicular Activity Time on the Lunar Surface Based on ISS Operations” Space 2005, AIAA 2005-6697

Seelig, H.D. (2005) The Assessment of Water Deficit Stress in Plants using Optical Measurement Methods. Doctoral Thesis, University of ŷ���ڱ���Ƶ, Boulder Stroud, K.J., Harm, D.L. and Klaus, D.M. (2005) “Preflight Virtual Reality Training as a Countermeasure for Space Motion Sickness and Disorientation” Aviation, Space and Environmental Medicine 76:352-356

Yuan, YY, Kostenuik,, PJ, Morony, S, Adamu, S, Asuncion, F. and Bateman, TA (2005) “Continuous Administration of RANKL Caused High Bone Turnover and Bone Loss in Rats.” In Bone Loss during Spaceflight Symposium Proceedings, Cleveland Clinic, Cleveland, OH.

Yuan, YY, Lau, AG, Kostenuik,, PJ, Morony, S, Adamu, S, Asuncion, F, and Bateman, TA (2005) “RANKL Has Detrimental Effects on Cortical and Trabecular Bone Volume, Mineralization and Bone Strength In Mice.” In ASBMR Bone Quality Meeting Proceedings.

Yuan, YY, Lau, AG, Kostenuik,, PJ, Morony, S, Adamu, S, Asuncion, F, and Bateman, TA (2005) “RANKL Has Detrimental Effects on Cortical and Trabecular Bone Volume, Mineralization and Bone Strength In Mice.” 27th American Society for Bone and Mineral Research Annual Meeting.

2004

Bandstra ER, Barth JL, Argraves WS, Bateman TA (2004) “Analysis of gene array changes in muscle caused by spaceflight.” Grav Space Biol Bul 18:12. (abstract)

Bateman TA (2004) “Molecular therapies for disuse osteoporosis.” Grav Space Biol Bul 17:83-89.

Bembey AK, Koonjul A, Bushby AJ, Ferguson VL, Boyde A. (2004) “Contribution of collagen, mineral and water phases to the nanomechanical properties of bone.” Fall 2004 MRS Proceedings: Fundamentals of Nanoindentation and Nanotribology III.

Benoit, M.R. and Klaus. D.M. (2004) “Mitigating the Effects of Clinorotation on Escherichia coli through Induced Cellular Neutral Buoyancy” (abstract) Gravitational and Space Biology Bulletin 18(1): p. 21

Bushby AJ, Ferguson VL, Boyde A. (2004) “Nanoindentation of bone: comparison of specimens tested in liquid and embedded in PMMA.” J Mat Res, 19:249-259.

Chappell SP and Klaus DM (2004) “Adaptation of terrestrial mountaineering equipment and training methods for planetary EVA operations.” 34th ICES, SAE Technical Paper ICES 2004-01-2290

Clark KL, Oelke A, Johnson ME, Eilert KD, Simpson PC, Todd SC (2004) “CD81 associates with 14-3-3 in a redox-regulated palmitoylation-dependent manner.” J Biol Chem 279:19401-19406.

Czupalla M, Aponte V, Chappell S, Klaus D (2004) “Analysis of a spacecraft life support system for a Mars mission.” Acta Astronautica 55:537-547.

Ferguson VL, Bushby AJ, Boyde A. (2004) “Elastic modulus of dental enamel: Effect of enamel prism orientation and mineral content.” Fall 2004 MRS Proceedings: Fundamentals of Nanoindentation and Nanotribology III.

Goulart CV, Woodard S, Rupert M, Stodieck LS (2004) “Performance of the STARS™ life sciences habitats in spaceflight and ground controls.” 34th ICES, SAE Technical Paper ICES 2004-01-2394.

Harris LG, Pecaut MJ, Obenaus A, Nelson GA, Gridley DS, Bateman TA (2004) “The effects of radiation on the rat bone.” Grav Space Biol Bul 18:20. (abstract)

Hatfield, T.R. (2004) Development of Novel Ultrasonic Physiological Measurement Methodologies Appropriate for Space Flight. Doctoral Thesis, University of ŷ���ڱ���Ƶ, Boulder

Hatfield TR, Klaus DM, Simske SJ (2004) “An ultrasonic methodology for muscle cross section measurement to support spaceflight.” Micrograv Sci and Tech, 15(3)3-11.

Heyenga AG, Stodieck LS, Hoehn A, Kliss M, Blackford C (2004) "Approaches in the design of a space plant cultivation facility for Arabidopsis thaliana." 34th ICES, SAE Technical Paper ICES 2004-01-2459.

Hoehn, A., Klaus, D. and Stodieck, L. (2004) “A Modular Suite of Hardware Enabling Space Flight Cell Culture Research” J. Gravitational Physiology 11(1): 39-50

Howard, H.N. and Klaus, D.M. (2004) “Antibiotic Effectiveness in Simulated Microgravity” (abstract) Gravitational and Space Biology Bulletin 18(1): p. 10 Klaus, D.M. (2004) “Bioastronautics in Aerospace Engineering Sciences” (abstract) Gravitational and Space Biology Bulletin 18(1): p.32

Klaus DM (2004) “Gravitational influence on biomolecular engineering processes.” Grav Space Biol Bul 17(2):51-65.

Klaus D, Chluda H, Ellis T, Fehring J, Howard H, Jairala J, Lloyd T, Matthews D, Morris K, Rowley K, Sauers C, Stephens T (2004) “Systems engineering evaluation of a Mars habitat design.” 34th ICES, SAE Technical Paper ICES 2004-01-2372.

Klaus, D., Benoit, M., Nelson, E. and Hammond, T. (2004) “Extracellular Mass Transport Considerations for Space Flight Research Concerning Suspended and Adherent in vitro Cell Cultures” J. Gravitational Physiology 11(1): 17-28

Manley, J.M., Benoit, M.R. and Klaus, D.M. (2004) “Non-invasive Measurement of the Population Density of E. coli Grown in Simulated Microgravity” (abstract) Gravitational and Space Biology Bulletin 18(1): p. 6

Medine GM, Zaikovskii V, Klabunde, KJ (2004) “Synthesis and adsorption properties of intimately intermingled mixed metal oxide nanoparticles.” J Mater Chem 14:757-763.

Miesse AM, Willey JS, Bateman TA (2004) “Potential role of proinflammatory cytokines in nerve damage related bone loss.” Biomed Sci Instrumen 40:266-271.

Milstead JR, Simske SJ, Bateman TA (2004) “Comparison of skeletal disuse models in mice: spaceflight versus hindlimb suspension.” J Bone Miner Res 21:M216. (abstract)

Milstead JR, Simske SJ, Bateman TA (2004) “Spaceflight and hindlimb suspension disuse models in mice.” Biomed Sci Instrumen 40:105-110.

Pecaut MJ, Green LM, Bianski B, Jones TA, Nelson GA, Kostenuik PJ, Bateman TA, Morony, S, Stodieck, LS, Lacey, DL, Simske, SJ, Gridley, DS (2004) “Effects of spaceflight on hepatic gene expression in the C57BL/6 Mouse.” Grav Space Biol Bul 18:56. (abstract)

Seelig H-D, Klaus DM, Stodieck LS and Hoehn A (2004) “Non-contact measurement methods of detecting plant water deficit stress for space flight growth chamber application” 34th ICES, SAE Technical Paper ICES 2004-01-2455

Stroud, K.J. (2004) Mitigating Vestibular Disturbances During Spaceflight Using Virtual Reality Training and Reentry Vehicle Design Guidelines. Doctoral Thesis, University of ŷ���ڱ���Ƶ, Boulder

Thacker RE, Bateman TA (2004) “Differentiating the contribution of material and structural properties to changes in bone mechanical strength.” J Bone Miner Res 1:SU234. (abstract)

Yuan YY, Ferguson VL, Simske SJ, Bateman TA (2004) “Low dose administration of macrophage colony stimulating factor.” Biomed Sci Instrumen 40:93-98.

2003

Benoit, M.R., D.M. Klaus and E.S. Nelson (2003) “Computational Modeling of Extracellular Mass Transport” (abstract) Gravitational and Space Biology Bulletin 17(1): p. 11

Clawson, J., Hoehn, A., Maute K. (2003) "Materials for transparent inflatable greenhouses", SAE-paper 2003-01-2326. International Conference On Environmental Systems (ICES), July 2003, Vancouver, Canada.

Dalton P, Gould M, Girten B, Stodieck LS, Bateman TA (2003) “Preventing annoyance from odors in spaceflight: a method for evaluating the sensory impact of rodent housing.” J Appl Physiol 95:2113-2121.

Ferguson, VL, Ayers, RA, Bateman, TA, Simske, SJ Bone development and age-related bone loss in male C57BL/6J mice. Bone 33:387-398; 2003.

Gridley, DS, Nelson, GA, Peters, LL, Kostenuik, PJ, Bateman, TA, Morony, S, Stodieck, LS, Lacey, DL, Simske, SJ, Pecaut, MJ Effect of spaceflight on immunity in the C57BL/6 mouse, Part II: Activation, cytokines, erythrocytes, and platelets. J Appl Physiol 94:2095-2103; 2003.

Harrison BC, Allen DL, Stodieck LS, Kostenuik PJ, Bateman TA, Morony, S, Leinwand, LA (2003) “Skeletal muscle adaptations to microgravity in the mouse.” J Appl Physiol 95:2462-2470.

Hatfield, T.R. and Klaus, D.M. (2003): “Development of Quantitative Ultrasonic Physiological Measurement Technology for Space Flight Application” International Academy of Astronautics (IAA) Humans in Space Symposium, Banff, Alberta, May 2003

Hoehn, A., Clawson, J., Geissinger, T., Kalinowski, W., Pineau, J., Scovazzo, P. (2003): “Design, Testing and Operation of Porous Media for Dehumidification and Nutrient Delivery in Microgravity Plant Growth Systems”. SAE-paper 2003-01-2614, International Conference On Environmental Systems (ICES), July 2003, Vancouver, Canada. PC.

Hoehn, A., Clawson, J., Freeman, J., Genova, J., Gifford, K., Stodieck, L. (2003): “Thermal Design of a Spaceflight Plant Chamber Payload”. SAE-paper 2003-01-2583, International Conference On Environmental Systems (ICES), July 2003, Vancouver, Canada.

Hoehn, A., Sampson, M., Seelig, H., Stodieck, L., Heyenga, A.G. (2003): “Spaceflight Plant Science Integration, Testing and Functional/Compatibility Verification”. SAE-paper 2003-01-2480, International Conference On Environmental Systems (ICES), July 2003, Vancouver, Canada. PC.

Klaus, D.M. (2003) “Gravitational Influence on Biomolecular Engineering Proesses” (abstract) Gravitational and Space Biology Bulletin 17(1): p. 22.

Miesse AM, Milstead JR, Bateman TA (2003) “Comparing effects of trabecular bone using two nerve damage disuse models in mice: sciatic nerve crush and sciatic neurectomy.” Grav Space Biol Bul 17:62. (abstract)

Milstead JR, Miesse AM, Kostenuik PJ, Morony, S, Ferguson, VL, Simske, SJ, Lacey, DL, Bateman, TA (2003) “MicroCT analysis demonstrates OPG mitigates loss of spaceflight osteopenia in proximal humerus of mice.” Grav Space Biol Bul 17:62. (abstract)

Pecaut, MJ, Nelson, GA, Peters, LL, Kostenuik, PJ, Bateman, TA, Morony, S, Stodieck, LS, Lacey, DL, Simske, SJ, Gridley, DS Effect of spaceflight on immunity in the C57BL/6 mouse, Part I: Immune population distribution. In press for: J Appl Physiol 94:2085-2094; 2003.

Prasad BLV, Stoeva SI, Sorensen CM, Zaikovski V, Klabunde KJ (2003) “Gold nanoparticles as catalysts for polymerization of alkylsilanes to siloxane nanowires, filaments, and tubes.” J Am Chem Soc, 125:10488-10489.

Ries, R. Bockstahler, S., Higgins, C., Atkinson, K., Lewandowski, S., Gjestvang, R., Frey, A., Clawson, J., Klaus, D. "RedThumb: A Mars greenhouse design for the 2002 MarsPort engineering design student competition", SAE-paper 2003-01-2676. International Conference On Environmental Systems (ICES), July 2003, Vancouver, Canada.

Simons ML, Thacker RE, Yuan Y, Bateman TA (2003) “Spaceflight-induced changes in tibial bone formation in the mouse.” Grav Space Biol Bul 17:62. (abstract)

Simske, SJ, Ferguson, VL, Bateman, TA Mice and osteoporosis research. Pandalai, SG (ed.) Recent Research Developments in Biotechnology and Bioengineering vol. 5, ISBN 81-271-0011-0, Research Signpost, Kerala, India, pp. 97-127; 2003.

Stoeva S.I., Prasad BLV, Sitharaman U, Stoimenov P, Zaikovski V, Sorensen CM, Klabunde KJ (2003) “Face-Centered Cubic and Hexagonal Close-Packed Nanocrystal Superlattices of Gold Nanoparticles Prepared by Different Methods.” J Phys Chem B (invited paper for A. Henglein Special Issue), 107:7441-7448.

Stoimenov PK, Zaikovski V, Klabunde KJ; (2003). “Novel Halogen and Interhalogen Adducts of Nanoscale Magnesium Oxide.” J Am Chem Soc, 125:12907-12913.

Stroud, K.J., Harm, D.L. and Klaus, D.M. (2003): “Virtual Reality Training in Unfamiliar Environments: A Potential Countermeasure for Space Motion Sickness and Spatial Disorientation During Space Flight” 54th International Astronautical Congress (IAC), Bremen, Germany, October 2003

Stroud, K.J., Klaus, D.M. and Harm, D.L. (2003): “Applications of Vestibular System Response to Mission Risk Mitigation Factors and Spacecraft Design Requirements” SAE Technical Paper 2003-01-2535.

Thacker, RE, Yuan Y, Bateman TA (2003) “Mineral characterization of mouse bone after exposure to micro-gravity using Fourier transform infrared (FTIR) spectroscopy.” Grav Space Biol Bul 17:62 (abstract)

Woodard, S., Goulart, C., Hoehn, A. (2003) "Performance of the STARS life sciences payload during benchtop testing and mission simulations", SAE-paper 2003-01-2530. International Conference On Environmental Systems (ICES), July 2003, Vancouver, Canada.

Zawieja DC, Nelson GA, Peters LL, Kostenuik PJ, Bateman TA, Morony S, Stodieck LS, Lacey DL, Simske SJ, Delp MD.  Genetic models in applied physiology: selected contribution: effects of spaceflight on immunity in the C57BL/6 mouse. II. Activation, cytokines, erythrocytes, and platelets. Journal of Applied Physiology. 2003; 94(5): 2095-2103.

2002

Bateman, TA, Morony, S, Ferguson, VL, Simske, SJ, Lacey, DL, Warmington, KS, Dunstan, CR, Stodieck, LS, Kostenuik, PJ Spaceflight-induced changes in mouse bone and osteoprotegerin therapy. Grav Space Biol Bul 16:30; 2002. (abstract)

Brown, R., Klaus, D. and Todd, P. (2002): “Effects of space flight, clinorotation and centrifugation on the substrate utilization efficiency of E. coli” Microgravity Sci. and Tech XIII/4: 24-29

Ferguson, VL, Simske, SJ, Ayers, RA, Bateman, TA, Wang, HT, Bendele, A, Rich, B, Collins, D, Scherrer, J, Sennollo, R, Colagiovanni, DB (2002): Effect of MPC-11 Myeloma and MPC-11 + IL-1ra Treatment on Mouse Bone Properties. Bone 30:109-116

Ganta, R.R., Wilkerson, M.J., Cheng, C., Rokey, A.M., and Chapes, S.K. (2002) “Persistent Ehrlichia chaffeensis infection occurs in the absence of functional MHCII genes.” Infect. Immun. 70:380-388.

Girten, B, Hoopes, R, Steele, M, Bateman, TA Effects of microgravity on oxidative and anti-oxidant enzymes in mouse hindlimb muscle. Grav Space Biol Bul 16:38; 2002. (abstract)

Gridley, DS, Nelson, GA, Peters, LL, Kostenuik, PJ, Bateman, TA, Morony, S, Stodiek, LS, Lacey, DL, Simske, SJ, Pecaut, MJ Spaceflight and immunity in the mouse: Part II. Grav Space Biol Bul 16:61; 2002. (abstract)

Goulart, C., Rupert, M., Woodard, S., Hoehn, A. (2002) “Habitat Development in Support of Small Scale Biological & Biochemical Space Experiments.” SAE Technical paper. Presented at the International Conference On Environmental Systems, July, San Antonio, TX, USA.

Harrison, BC, Allen, DL, Stodieck, LS, Kostenuik, PJ, Bateman, TA, Morony, S and Leinwand, LA Micro-gravity exposure results in significant atrophy of murine skeletal muscle without alterations in myosin heavy chain gene expression. Grav Space Biol Bul 16:20; 2002. (abstract)

Hua, D.H., Tamura, M., Huang, X., Stephany, H.A., Helfrich, B.A., Perchellet, E.M., Sperfslage, B.J., Perchellet, J.P., Jiang, S., Kyle, D.E., Chiang, P.K. (2002) “Syntheses and bioactivities of substituted 9,10-dihydro-9,10- [1,2]benzenoanthra­cene-1,4,5,8-tetraones. Unusual reactivities with amines.” J Org Chem. 67: 2907- 2912.

Klaus, D.M. (2002): “Space Microbiology: Microgravity and Microorganisms” in The Encyclopedia of Environmental Microbiology, G. Britton (ed.), John Wiley & Sons, NY, pp. 2996-3004

Klessig, D.F., Kachroo, P.K., Slaymaker, D., Yoshioka, K., Navarre, D.A., Clark, D., Kumar, D., and Shah, J. (2002) “SA- and NO-mediated signaling in Plant Disease Resistance.” In: Biology of Plant-Microbe Interactions. Ed. S.A. Leong, C. Allen, and E.W. Triplet, IS-MPMI, St Paul, MN. Vol. 3, pp 78-82.

Lam, K.S., Gustavson, D.R., Pirnik, D.L., Pack, E., Bulanhagui, C., Mamber, S.W., Forenza, S., Stodieck, L.S. and Klaus, D.M. (2002): “The effect of space flight on the production of actinomycin D by Streptomyces plicatus” J. Industrial Microbiology and Biotechnology 29 (6): 299-302.

Maezawa, I., Hua, D.H, Shie, F., Alvord, E., Martin, G.M., and Jin, L.W. (2002) “Novel tricyclic pyrone compounds prevent intracellular A-beta-related cell death.” J. Neuropathol. Exp. Neurol. 61, 454, Abst. # 48.

Marchin, GL, A Eberth, P Stoimenov, K Nelson and K Klabunde. (2002) “Inactivation of the algal toxin microcystin LR by nanoparticles.” Proc Ann Meet ASM Q-118 p. 398.

Owen, R.B., Zozulya, A.A., Benoit, M.R. and Klaus, D.M. (2002): “Microgravity materials and life sciences research applications of digital holography” J. Applied Optics 41: 3927-3935

Pecaut, MJ, Nelson, GA, Peters, LL, Kostenuik, PJ, Bateman, TA, Morony, S, Stodiek, LS, Lacey, DL, Simske, SJ, Gridley DS Spaceflight and immunity in the mouse: Part I. Grav Space Biol Bul 16:30; 2002. (abstract)

Perchellet, E.M., Sperfslage, B.J., Wang, Y., Huang, X., Tamura, M., Hua, D.H., and Perchellet, J.P. Among substituted 9,10-dihydro-9,10-[1,2]benzenoanthracene-1,4,5,8-tetraones, the lead antitumor triptycene bisquinone TT24 blocks nucleoside transport, induces apoptotic DNA fragmentation and decreases the viability of L1210 leukemic cells in the nanomolar range of daunorubicin in vitro. Anti-Cancer Drugs, 2002, 13, 567-581.

Sharvelle, S. Silverstein, J. Supra, L., Finger, B. and Klaus, D. (2002) “Nitrite Accumulation in a Bioprocessor for Urine-Soap Waste” 32nd ICES SAE Technical Paper 2002-01-2353

Simmons, D., Benoit, M., Freeman, J., Genova, J and Hoehn, A. (2002) "Designing Fluid Handling Systems for Space Life Science Experimentation", SAE Technical Paper 2002-01-2281. Presented at the International Conference On Environmental Systems, July, San Antonio, TX, USA.

Simske, S.J., Bateman, T.A., Smith, E.E., Ferguson, V.L., and Chapes, S.K. (2002) “Effects of major histocompatibility complex class II knockout on mouse bone mechanical properties during development.” Proceed. Biomed. Sci. Instrum. 38:47-52.

Stoimenov, P., Klinger, R.L., Marchin, G.L., and Klabunde, K.J. (2002) “Metal oxide nanoparticles as bactericidal agents.” Langmuir. 18:6679-6686.

Wang, Y., Perchellet, E.M., Tamura, M., Hua, D.H., and Perchellet, J.P. Induction of poly(ADP-ribose) polymerase cleavage by antitumor triptycene bisquinones in wild-type and daunorubicin-resistant HL-60 cell lines. Cancer Letters (Shannon, Ireland), 2002, 188(1-2), 73-83.

2001

Bateman, T.A., Dunstan, C.R., Lacey, D.L., Ferguson, V.L. and Simske, S.J. (2001) Osteoprotegerin ameliorates sciatic nerve crush induced bone loss. J Orthoped Res. 19: 518-523

Chapes, S.K., Mosier, D.A., Wright, A.D., and Hart, M.L. (2001) “MHCII, Tlr4 and Nramp1genes control host pulmonary resistance against the opportunistic bacterium Pasteurella pneumotropica.” J. Leukoc. Biol. 69: 381-386.

Chapes, S.K., Wright, A.D., Beharka, A.A. (2001) “Superantigen activation of macrophages.”In: Staphylococcal Disease and Infection, eds., A.L. Honeyman, M. Bendinelli, H.Friedman, Kluwer Academic/Plenum. New York. July.

Ferguson, V.L., Hermann, L.K., Smith, E.E., Bateman, T.A., and Simske, S.J. (2001) “Effects of age and amylin treatment on long bones in growing and mature mice.” J Bone Miner Res. 16sup: S484.

Hua, D.H, McGill, J.W, Robinson, P.D., and Meyers, C.Y. (2001) “Crystal structure of tri-[1’-(phenylthio)-1-ferrocenyl]boroxin.” Acta Cryst. E57, 413-415.

Jin, L.W., Hua, D.H., Shie, F.S., Maezawa, I., Sopher, B., and Martin, G.M. (2001) “Novel Tricyclic Pyrone Compounds Prevent Intracellular Amyloid beta-induced Cell Death.” The Institute for the Study of Aging (ISOA). (In press).

Klaus, D and Jost, J. (2001): “Analysis of Gravity-Dependent and Independent Extracellular Mass Transport Phenomena” in Proceedings of the Conference on Microgravity Transport Processes in Fluid, Thermal, Materials and Biological Sciences II, S. S. Sadhal (ed.), United Engineering Foundation, UEF: MTP-01-70, pp. 527-532.

Klaus, D.M. (2001) “Clinostats and Bioreactors” Gravitational and Space Biology Bulletin 14(2): 55-64.

Klaus, D, Benoit, M, Bonomo, J, Bollich, J. Freeman, J, Stodieck, L, McClure, G and Lam, KS (2001): “Antibiotic Production in Space using an Automated Fed-Bioreactor System” in Proceedings of the AIAA Conference on ISS Utilization, AIAA-2001-4921.

Koper, O.B, Klabunde, J.S., Marchin, G.L., Klabunde, K.J., Stoimenov, P. and Bohra, L. (2001) “Nanoscale powders and formulations with biocidal activity toward spores and vegetative of Bacillus species, viruses and toxins.” Current Microbiology 44:49-55.

Perchellet, E.M., Sperfslage, B.J., Qabaja, G., Jones, G.B., Perchellet, J.P. (2001) “Quinone isomers of the WS-5995 antibiotics: synthetic antitumor agents that inhibit macromolecule synthesis, block nucleoside transport, induce DNA fragmentation and decrease the growth and viability of L1210 leukemic cells more effectively than ellagic acid and genistein in vitro.” Anti-Cancer Drugs. 12: 401-417.

Pineau, J., Kalinowski, B and Hoehn, A. (2001) “Autonomous Two-Phase Priming and Pressure Control System for Microgravity Porous Tube Hydroponics” KC-135 and Other Microgravity Simulations Summary Report, NASA Space and Life Sciences Directorate CR-208929: pp. 134-141

Ross, ר, Bateman, TA, Kostenuik, PJ, Lacey, DL, Dunstan, CR, Ferguson, VL, Simske, SJ (2001) Effect of osteoprotegerin on the mechanical properties of rat bone. J Mat Sci: Mat Med 12: 583-588.

Perchellet, E.M., Sperfslage, B.J., McIlvain, C.J., Aligiannis, N., Pouli, N., Marakos, P., Skaltsounis, A-L., Perchellet, J.P. (2001) “Antileukemic activity of synthetic daunomycinone derivatives bearing modifications in the glycosidic moiety.” Anticancer Res. 21: 3957-3968.

Scovazzo, P., Illangasekare, T.H., Hoehn, A., and Todd, P. (2001) Modeling of two-phase flow in membranes and porous media in microgravity as applied to plant irrigation in space. Water Resources Res. 37(5): 1231-1243.

Stodieck, L., Hoehn, A., and Klaus, D. (2001) “Commercial Space Life Sciences Research: Opportunities and Challenges on the International Space Station” in Proceedings of the AIAA Conference on ISS Utilization, AIAA-2001-4911.

Vellinger, J., Barton, K.W., Doyle, J.F., Wells, M.E., Todd, P. and Chapes, S.K. (2001) “Multiple robotic cell culture bioreactor systems for cell and tissue research in low gravity.” AIAA Paper 2001-5012, American Institute of Aeronautics and Astronautics Proceedings on International Space Station Utilization. Washington, DC.

Wang, B., Wu, M., Perchellet, E.M., McIlvain, C.J., Sperfslage, B.J., Huang, X., Tamura, M., Stephany, H.A., Hua, D.H., Perchellet, J.P. (2001) “A synthetic triptycene bisquinone, which blocks nucleoside transport and induces DNA fragmentation, retains its cytotoxic efficacy in daunorubicin-resistant HL-60 cell lines.” Int J Oncology. 19: 1169-1178.

Wu, M., Wang, B., Perchellet, E.M., Sperfslage, B.J., Stephany, H.A., Hua, D.H., Perchellet, J.P. (2001) “Synthetic 1,4- anthracenediones, which block nucleoside transport and induce DNA fragmentation, retain their cytotoxic efficacy in daunorubicin-resistant HL-60 cell lines.” Anti-Cancer Drugs. 12: 807-819.

2000

Ayers, R.A., Bateman, T.A. and Simske, S.J. (2000) “Porous NiTi as a material for bone engineering.” LH Yahia (ed) Shape Memory Implants, Springer-Verlag, New York.

Bateman, TA, Dunstan, CR, Ferguson, VL, Lacey, DL, Ayers, RA, Simske, SJ (2000) “Osteoprotegerin mitigates tail suspension induced osteopenia.” Bone, 26: 443-449.

Bateman, TA, Stodieck, LS, Kostenuik, PJ, Ferguson, VL, Simske, SJ (2000) Use of Spaceflight and Spaceflight Simulation to Provide Evidence for Osteoprotegerin Treatment of Disuse Osteoporosis. Space Tech Appl Int Forum ’00 2:580-581.

Chapes, S.K., Wright, A.D. and Beharka, A.A. (2000) “Superantigen activation of macrophages.” Staphylococcal Disease and Infection, Honeyman, A.L., Bendinelli, M. and Friedman, H. – Editors, Kluwer Academic/Plenum, New York.

Clawson, J.M., Hoehn, A., Stodieck, L.S., Todd, P., and Stoner, R.J. (2000) “Re-examining aeroponics for spaceflight plant growth.” Society of Automotive Engineers Technical Paper Series, No. 2000-01-2507, 30th International Conference on Environmental System, Toulouse, France; July 9-13.

Clawson, J.M., Hoehn A., Stodieck, L., Todd, P. and Cadogan, D. (2000) “Optimizing the structural subsystem of the AG-Pod crop production unit.” Society of Automotive Engineers Technical Paper Series, No. 2000-01-2477, 30th International Conference on Environmental System, Toulouse, France; July 9-13.

Ferguson, VL, Ayers, RA, Bateman, TA, Simske, SJ (2000) Development of endogenous osteoporosis in male C57BL/6J mice. J Bone Miner Res 15sup: S461.

Gifford, K.K. (2000) "Linux at the University: In Space, on the Ground, and in the Classroom," Linux Journal, 77: pp. 56-70.

Hermann, LK, Ferguson, VL, Bateman, TA, Simske, SJ (2000) Combined treatment effects of IGF-I and M-CSF on mouse bone composition, mechanical properties and quantitative histomorphometry. J Bone Miner Res 15sup:S369.

Heyenga, A.G. Forsman, A. Stodieck, L.S., Hoehn, A. and Kliss, M. (2000) “Approaches in the Determination of Plant Nutrient Uptake and Distribution in Space Flight Conditions,” Advances in Space Research, 26(2): 299-302.

Heyenga A.G., Hoehn, A., Stodieck, L. and Kliss, M. (2000), “The design of a mechanized seed sowing system for space flight application” Society of Automotive Engineers Technical Paper Series, No. 2000-01-2506, 30th International Conference on Environmental Systems, Toulouse, France; July 9-13.

Hoehn A., Stodieck, L. Clawson, J., Robinson, E., Seelig, H., Heyenga, A.G., and Kliss, M. (2000) “Atmosphere control of spaceflight plant growth chambers” Society of Automotive Engineers Technical Paper Series, No. 2000-01-2232, 30th International Conference on Environmental Systems, Toulouse, France; July 9-13.

Hoehn, A., Scovazzo, P., Stodieck, L., Clawson, J., Kalinowski, W., Rakow, A. Simmons, D., Heyenga, A.G. and Kliss, M. (2000) “Microgravity Root Zone Hydration Systems” Society of Automotive Engineers Technical Paper Series, No. 2000-01-2510, 30th International Conference on Environmental Systems, Toulouse, France; July 9-13.

Hua, D.H., Takasu, K., Huang, X., Millward, G.S., Chen, Y., Liu, L.Z. and Fan, J.M. (2000) “Palladium-mediated ring closure reactions. Facile syntheses of enantiopure bicyclic and tricyclic alkenones.” Tetrahedron 56:7389-7398.

Khramtsov, N.V. and Upton, S.J. (2000) “Association of RNA polymerase complexes of the parasitic protozoan Cryptosporidium parvum with virus‑like particles: heterogeneous system.” J. Virol, 74(13): 5788‑5795.

Khramtsov, N.V., Chung, P.A., Dykstra, C.C., Griffiths, J.K., Morgan, U.N., Arrowood, M.J. and Upton, S.J. (2000) “Presence of dsRNAs in human and calf isolates of Cryptosporidium parvum.” J. Parasitol, 86(2): 275‑282.

Klaus, D. (2000): “Commercial Microbial Research: From Spacelab to the International Space Station” in Proceedings from The Spacelab Accomplishments Forum. J. Emond (ed.), NASA/CP-2000-210332, pp. 223-238.

Kliss, M., Heyenga, A.G., Hoehn, A. and Stodieck, L.S. (2000) “Recent Advances in Technologies Required for a Salad Machine” Advances in Space Research, 26(2): 263-269.

Kliss, M., Heyenga, A.G., Hoehn, A., and Stodieck,L.S. (2000) “Towards the development of a Salad Machine" Society of Automotive Engineers Technical Paper Series, No. 2000-01-2476, 30th International Conference on Environmental Systems, Toulouse, France; July 9-13.

Lindsay, D.S., Woods, K.M., Upton, S.J. and Blagburn, B.L. (2000) “Activity of decoquinate against Cryptosporidium parvum in cell cultures and neonatal mice.” Vet. Parasitol, 89: 307‑311.

Morgan, U.M., Xiao, L., Monis, P., Sulaiman, I., Pavlasek, I., Blagburn, B.L., Olsen, M., Upton, S.J, Khramtsov, N.K., Lal, A., Elliot, A. and Thompson, R.C.A. (2000) “Molecular and phylogenetic analysis of Cryptosporidium muris from various hosts.” Parasitology, 120(5): 457‑464.

Morgenthaler, George W. and Woodcock, Gordon R. (2000) “Implementing Settlement-Compatible Mars Transportation Architectures,” IAF/IAA-00-13.3.02, presented at the 51st International Astronautical Congress, Rio de Janeiro, Brazil, Oct.2-Oct.6, 2000.

Morgenthaler, George W. and Clark, Ben C. (2000) “Robots for Human Missions to Mars: The Fifth Application,” IAA-00-IAA-13.1.01, presented at the 51st International Astronautical Congress, Rio de Janeiro, Brazil, Oct.2-Oct.6, 2000.

Pecaut, MJ, Simske SJ, and Fleshner M. (2000): Spaceflight induces changes in splenocyte subpopulations: effectiveness of ground-based models. Am J Physiol Regulatory Integrative Comp Physiol 279: R2072-R2078.

Perchellet, E.M., Magill, M.J., Huang, X., Dalke, D.M., Hua, D.H., and Perchellet, J.P. (2000) “1,4-Anthraquinone: an anticancer drug that blocks nucleoside transport, inhibits macromolecule synthesis, induces DNA fragmentation and decreases the growth and viability of L1210 leukemic cells in the same nanomolar range than daunorubicin in vitro.” Anti-Cancer Drugs, 11: 339-352.

Perchellet, Q.G., Perchellet, E.M., Jones, G.B., (2000) “Regioselective lactonization of naphthoquinones: synthesis and antitumoral activity of the WS-5995 antibiotics.” Tetrahedron Lett, 41: 3007-3010.

Supra, L.N., Finger, B.W., Reddig, M.A., MacKnight, A.K., Silverstein, J., Klaus, D.M., Urban, J.E. and Strayer, D.F. (2000) “Biological Wastewater Processor Experiment Definition” Society of Automotive Engineers Technical Paper Series, No. 2000-01-2468, 30th International Conference on Environmental Systems, Toulouse, France; July 9-13.

Wells, B., Hoehn, A. and Levine, H. (2000) “Collaborative development of a spaceflight experiment comparing two plant nutrient delivery systems” Society of Automotive Engineers Technical Paper Series, No. 2000-01-2509, 30th International Conference on Environmental Systems, Toulouse, France; July 9-13.

Wessling, F.C., Stodieck, L.S., Hoehn, A., Woodard, S., and Thomas, S. (2000) “Low temperature, low energy carrier (LoTec) and phase change materials (PCMS) for biological samples” Society of Automotive Engineers Technical Paper Series, No. 2000-01-2506, 30th International Conference on Environmental Systems, Toulouse, France; July 9-13.

Zhao, K., An, K., Fattaey, H. and Johnson, T. (2000) “CeReS-18, a Cell Regulatory Sialoglycopeptide, Inhibits Proliferation and Migration of Rat Vascular Smooth Muscle Cells.” Experimental Cell Research, 260: 181-188.

Zhu, G., Marchewka, M.J, Woods, K.M., Upton, S.J. and Keithly, J.S. (2000) “Molecular analysis of a type I fatty acid synthase in Cryptosporidium parvum.” Mol. Biochem. Parasitol, 105(2): 253‑260.

1999

Ayers, R.A., Simske, S.J., Bateman, T.A., Petkus, A., Sachdeva, R.L.C., and Gyunter, V.E. (1999): Effect of nitinol implant porosity on cranial bone ingrowth and apposition after 6 weeks. J Biomed Mater Res. 45: 42-47.

Ayers, R.A., Wolford, L.M., Bateman, T.A., Ferguson, V.L., and Simske, S.J. (1999): Quantification of bone ingrowth into porous block hydroxyapatite in humans. J Biomed Mater Res. 47: 54-59.

Bateman, TA, Ayers, RA, Greenway, RB (1999) An engineering evaluation of four fluid transfer devices for 384-well high throughput screening. Lab Robotics and Automat 11:250-259.

Bateman, TA, Lacey, DL, Ferguson, VL, Dunstan, CR, Ayers, RA, Simske, SJ (1999) Comparison of osteoprotegerin, pamidronate and ibandronate in the treatment of suspension induced osteopenia. J Bone Miner Res 14sup: S528.

Bateman, TA, Kostenuik, PJ, Ferguson, VL, Ayers, RA, Simske, SJ (1999) Osteoprotegerin treatment of tail suspension and sciatic nerve crush disuse osteopenia: comparison with bisphosphonates. Grav Space Biol Bul 13:51.

Brown, R.B. (1999) Effects of space flight, clinorotationand centrifugation on the growth and metabolism of Escherichia coli. Doctoral Dissertation, University of ŷ���ڱ���Ƶ, Boulder.

Chapes, S.K., Simske, S.J., Sonnenfeld, G., Miller, E.S., and Zimmerman, R.J. (1999) Effects of spaceflight and PEG-IL-2 on rat physiological and immunological responses. J. Appl. Physiol. 86: 2065-2076.

Chapes, S.K., Simske, S.J., Forsman, A.D., Bateman, T.A., and Zimmerman, R.J. (1999) Effects of space flight and IGF-1 on immune function. Adv. In Space Research. 23: 1955-1964.

Fattaey, H.K., Quinton, T.M., Zhao, K., He, F., Paulsen, Q. and Johnson, T.C. (1999) CeReS-18 inhibits growth and induces apoptosis in human prostate cancer cells. The Prostate. 38: 285-295.

Ferguson, VL, Bateman, TA, Lacey, DL, Ayers, RA, Dunstan, CR, Simske, SJ (1999) Effect of osteoprotegerin on mechanical and material properties of maturing rat femora. J Bone Miner Res 14sup:S440.

Ferguson, V.L., Greenberg, A.R., Bateman, T.A., Ayers, and R.A., Simske, S.J. (1999) Effect of age and dietary restriction without nutritional supplementation on whole bone structural properties in C57BL/6J mice. Biomed. Sci. Instrument. 35: 85-91.

Forsman, A.D., Herpich, A.R. and Chapes, S.K. (1999) “Improved soft-agar colony assay in a fluid processing apparatus.” In Vitro Cell and Developmental Biology, 35: 55-60.

Hoehn, A., Clawson, J.M., Heyenga, A.G., Scovazzo, P., Sterrett, K.S., Stodieck, L.S., Todd, P., and Kliss, M.H. (1999) Mass transport in a spaceflight plant growth chamber. SAE 1998 Transactions/J. of Aerospace. 107(1).

Hoehn, A., Clawson, J.M., and Stodieck, L.S. (1999). “AG Pod - The Integration of Existing Technologies for Efficient, Affordable, Space Flight Agriculture“. Proceedings, ICES 1999, Denver, SAE paper 1999-01-2176.

Hoehn, A., Freeman, J.B., and Stodieck, L.S. (1999). “Incubator Designs for Space Flight Application - Optimization and Automation“. Proceedings, ICES 1999, Denver, SAE paper 1999-01-2177.

Hua, D.H., Chen, Y., Sin, H.S., Robinson, P.D., Meyers, C.Y., Perchellet, E.M., Perchellet, J.P., Chiang, P.K. and Biellmann, J.F. (1999) “6,7,8,9-Tetrahydro-3-methyl-1H-pyrano[4,3-b]quinoline-1-one.” Acta Cryst, C55: 1698-1701.

Hua, D.H., Chen, Y. and Millward, G.S. (1999) “N-Alkylidenesulfinamides.” Sulfur Reports, 21 (Suppl. 3): 211-239.

Kacena, M.A., Merrell, G.A., Manfredi, B., Smith, E.E., Klaus, D.M., and Todd, P. (1999). Bacterial growth in space flight: logistic growth curve parameters for Escherichia coli and Bacillus subtilis. Appl. Microbiol. Biotechnol. 51: 229-234.

Kacena, M.A., Smith, E.E., and Todd, P. (1999). Autolysis of Escherichia coli and Bacillus subtilis cells in low gravity. Appl. Microbiol. Biotechnol. 51: 229-234.

Klein, R.D., Geary, T.G., Gibson, A.S., Favreau, M.A., Winterrowd, C.A., Upton, S.J., Keithly, J.S., Zhu, G., Malmberg, R.L., Martinez, M.P. and Yarlett, N. (1999) “Reconsitution of a bacterial/plant polyamine biosynthesis pathway in Saccharomyces cerevisiae.” Microbiology, 145: 301‑307.

Klement, B.J. and B.S. Spooner (1999) Mineralization and growth of cultured embryonic skeletal tissue in microgravity. Bone 24:349-359.

Lindsay, D.S., Upton, S.J. and Dubey, J.P. (1999) “A structural study of the Neospora caninum oocyst.” Int. J. Parasitol, 29: 1521‑1533.

Monday, S., Vath, G., Ferens, W., Deobald, C., Rago, J., Gahr, P.J., Monie, D.D., Iandolo, J.J., Chapes, S.K., Jenkins, M., Davis, W.C., Ohlendorf, D., Schlievert, P. and Bohach, G.A. (1999) “Unique superantigen activity of staphylococcal exfoliative toxins.” J. Immunol, 162: 4550-4559.

Morgenthaler, George W. and Woodcock, Gordon R. (1999) “Applying Cost/Benefit Modeling to Evaluating Human Mars Exploration Architectures,” IAF-99-13.3.07, presented at the 50th International Astronautical Congress, Amsterdam, The Netherlands, Oct.4-Oct.8, 1999.

Morgenthaler, George W. and Khatib, Nader (1999) “Use of Remote Sensing Agricultural “Truth” Sites to Validate and Enhance Precision Agriculture Practices,” IAF-99-B.5.10, 50th International Astronautical congress, Amsterdam, The Netherlands, Oct. 4-8, 1999.

Nesterenko, M.V., Woods, K.M. and Upton, S.J. (1999) “Receptor/ligand interactions between Cryptosporidium parvum and the surface of the host cell.” Biochimica et Biophysica Acta, 1454(2): 165‑173.

Perchellet, E.M., Ladesich, J.B., Magill, M.J., Chen, Y., Hua, D.H., and Perchellet, J.P. (1999) “Tricyclic pyrone analogs: a new synthetic class of bi-functional anti-cancer drugs that inhibit nucleoside transport, microtubule assembly, the viability of leukemic cells in vitro, and the growth of solid tumors in vivo.” Anti-Cancer Drugs, 10: 489-504.

Perchellet, E.M., Magill, M.J., Huang, X., Brantis, C.E., Hua, D.H., and Perchellet, J.P. (1999) “Triptycenes: a novel synthetic class of bi-functional anti-cancer drugs that inhibit nucleoside transport, induce DNA cleavage and decrease the viability of leukemic cells in the nanomolar range in vitro.” Anti-Cancer Drugs, 10: 749-766.

Perchellet, E.M., Ladesich, J.B., Collery, P., and Perchellet, J.P. (1999). Microtubule-disrupting effects of gallium chloride in vitro. Anti-Cancer Drugs. 10: 477-488.

Perchellet, E.M., Ladesich, J.B., Magill, M.J., Chen, Y., Hua, D.H., and Perchellet, J.P. (1999). Tricyclic pyrone analogs: a new synthetic class of bi-functional anti-cancer drugs that inhibit nucleoside transport, microtubule assembly, the viability of leukemic cells in vitro, and the growth of solid tumors in vivo. Anti-Cancer Drugs. 10: 489-504.

Robinson, P.D., Beatty, A., Hua, D.H., Chen, Y., Meyers, C.Y., Perchellet, E.M., Ladesich, J.B., and Perchellet, J.P. (1999). Racemic 3-(3,4-dimethoxyphenyl)-5a,6,8,9-tetrahydro-1H,7H-pyrano[4,3-b][1]benzopyran-1-one, an active anti-tumor agent. Acta Cryst. C55: 1188-1190.

Simske, SJ, Bateman, TA, Ayers, RA, Dunstan, CR, Ferguson, VL, Lacey, DL (1999) Effect of osteoprotegerin, pamidronate and ibandronate on the sciatic nerve crush model for disuse osteoporosis in mice. J Bone Miner Res 14sup:S523.

Smith, J.D., L. A. Staehelin and P. Todd. (1999) Clover germination, early growth and root cap morphology in space and on a two-axis clinostat. J. Plant Physiology 155: 543-550.

Todd, P., Doyle, J.F., Carter, P., Wachtel, H., Deuser, M.S., Vellinger, J.C., Cassanto, J.M., Alvarado, U., Sygusch, J., and Kent, T.B. (1999) Magnetic space shuttle experiments. J. Magnetism Magnetic Mat. 194: 96-101.

Todd, P, Pecaut MJ, and Fleshner M. (1999) Combined effects of space flight factors and radiation on humans. Mutation Res 430: 211-219.

Woods, K.M., Tilley, M., Iseli, A., Upton, S.J., Montelone, B.A. and Khramtsov, N.V. (1999) “Sequence of the gene encoding hsp90e from Cryptosporidium parvum.” DNA Sequence, 10(4‑5): 339‑342.

Wright, A.D. and Chapes, S.K. (1999) “LPS Sensitivity in recombinant mice lacking functional alleles at MHCII, Lps and Nramp1 genes.” J. Endotoxin Res, 5: 297-308.

Wright, A.D. and Chapes, S.K. (1999) “Staphylococcal enterotoxin: a bound to MHC class I requires cross linking for the induction of TNF-α.” Cellular Immunol, 197: 129-135.

1998

Anderson, G.A., MacCallum, T.K., Poynter, J.E. and Klaus, D.M. (1998): “Autonomous Biological System – A Unique Method of Conducting Long Duration Space Flight Experiments for Pharmaceutical and Gravitational Biology Research”. in Space Technology and Applications International Forum (STAIF), CP 420, M.S. El-Genk (ed.), The American Institute of Physics, DOE CONF 980103, pp. 616-621.

Ayers, R.A., Bateman, T.A., Chapes, S.K., Ferguson, V.L., Simske, S.J. (1998) “Effect of major histocompatability class II knockout on the mouse peripheral skeleton”. Bone 23:S441.

Ayers, R.A., Simske, S.J., Nunes, C.R., and Wolford, L.M. (1998): "Long-Term Bone Ingrowth and Residual Microhardness of Porous Block Hyroxyapatite Implants in Humans". J Oral Maxillofac Surg. 56: 1297-1301.

Ayers, R.A., Simske, S.J., Nunes, C.R., and Wolford, L.M. (1998) Long-term ingrowth and residual microhardness of porous block hydroxyapatite implants in humans. J Oral Maxilofac Surg. 56: 1297-1301.

Bateman, TA, Broz, JJ, Fleet, ML, Simske, SJ (1998) Differing effects of two-week suspension on male and female mouse bone metabolism. Biomed Sci Instrum 34:374-379.

Bateman, T.A., Dunstan, C.R., Ferguson, V.L., Ayers. R.A., Simske, S.J., (1998) “Osteoprotegerin increases femoral mechanical properties in control and tail suspended mice”. Bone. 23:S563.

Bateman, T.A., Zimmerman, R.J., Ayers, R.A., Ferguson, V.L. Chapes, S.K., and Simske, S.J., (1998) “Histomorphometric, Physical, and Mechanical Effects of Spaceflight and Insulin-like Growth Factor-1 on Rat Long Bones”. Bone 23: 527-535.

Chapes, S.K. and Herpich, A.R. (1998) Complex high affinity interactions occur between MHCI and superantigens. J. Leuko. Biol. 64: 587-594.

Ching-Yuan Lee, McEntyre, S.R., Todd, P. Schaefer, K., Kundrot, C.E., (1998): "Control of nucleation in oligonucleotide crystallization by the osmotic dewatering method with kinetic water removal rate control". Journal of Crystal Growth, 187: 490-498.

Ferguson, V.L., Bateman, T.A., Zimmerman, R.J., Ayers, R.A., Chapes, S.K., Simske, S.J. (1998) “Insulin-like growth factor-I inhibits endocortical bone formation for both spaceflight and ground control rats”. Bone 23:S560.

Hoehn, A., Clawson, J.M., Heyenga, A.G., Scovazzo, P., Sterrett, K.S., Stodieck, L.S., Todd, P., and Kliss, M.H. (1998) Mass transport in a spaceflight plant growth chamber. SAE Technical Paper Series 981553. SAE International, Warrendale, PA.

Klaus, D.M., Brown, R. and Cierpik, K. (1998): Antibiotic Production in Space: In El-Genk (ed.) Space Technology and Applications International Forum 1998, AIP Proc. 420: 633-637.

Klaus, D.M. (1998): “Microgravity and its Implication for Fermentation Technology”. Trends in Biotechnology 16 (9): 369-373.

Klaus, D.M., Todd, P. and Schatz, A. (1998): “Functional Weightlessness During Clinorotation of Cell Suspensions”. Advances in Space Research, 21 (8/9): 1315-1318.

Lam, K.S., Mamber, S., Pack, E., Forenza, S., Fernandes, P. and Klaus, D. (1998): “The Effects of Space Flight on the Production of Monorden by Humicola fuscoatra WC5157 in Solid State Fermentation”. Applied Microbiology and Biotechnology 49 (5): 579-583.

Lee, C.Y., McEntyre, S.R., Todd, P., Schaefer, K., and Kundrot, C.E. (1998) Control of nucleation in oligonucleotide crystallization by the osmotic dewatering method with kinetic water removal rate control. J. Crystal Growth. 0187: 490-498.

MacCallum, T., Anderson, G., Poynter, J., Stodieck, L. and Klaus, D. (1998) “Autonomous Biological Systems Experiments”. Biological Sciences in Space (Special Issue: Ecology in Space) 12 (4): 363-365.

Marchin, G. L. (1998). Resistance to chemical disinfection under conditions of microgravity. Space Technology and Applications International Forum –1998. The American Institute of Physics. Pp 765-768.

Morgenthaler, G.W., and Berryman, J., (1998) Commercial Life Sciences Prospects For the International Space Station - Building on Lessons Learned. Space Technology & Applications International Forum (STAIF - 98). Albuquerque, NM. January 25-29, 1998.

Newell, S., Perchellet, E., Ladesich, J., Freeman, J., Chen, Y., Lan-Zhou, L., Hua, D., Kraft, S., Basaraba, R., and Perchellet, J.P. (1998). Tricyclic Pyrone Analogs: A New Class of Microtubule-disrupting Anticancer Drugs Effective Against Murine Leukemia Cells In Vitro. International Journal of Oncology, 12: 433-442.

Newell, S.W., Perchellet, E.M., Ladesich, J.B., Freeman, J.A., Chen, Y., Sin, H., Hua, D.H., Kraft, S.L., Basaraba, R.J., and Perchellet, J.P. (1998) Tricyclic pyrone analogs: a new class of microtubule-disrupting anti-cancer drugs effective against murine leukemia cells in vitro. Intl. J. Oncology. 12: 433-442.

Perchellet, E.M., Ladesich, J.B., Chen, Y., Sin, H.S., Hua, D.H., Kraft, S.L., and Perchellet, J.P. (1998). Anti-tumor activity of tricyclic pyrone analogs, a new synthetic class of microtubule de-stabilizing agents, in the murine EMT-6 mammary tumor cell line in vitro. Anti-Cancer Drugs. 9: 565-576.

Perchellet, J.P., Perchellet, E.M., Newell, S.W., Freeman, J.A., Ladesich ,J.B., Jeong, Y., Sato, N., and Buszek, K.R. (1998). Anti-tumor activity of novel octalactin A analogs in murine leukemia cells in vitro. Anti-Cancer Res. 18: 97-106, 1998.

Quinton, T. M., Fattaey, H. K. Motaffaf, F. and Johnson, T. C. (1998) A model system for studies on bone matrix formation by osteogenic cells in microgravity. In: Space Technology and Applications International Forum; Third Conference on Commercial Development of Space, (ed., M. S. El-Genk), Amer. Instit. Physics Press, Woodbury, NY, pp. 622-626.

RaghavaRao, K.S.M.S., Stewart, R.M., Rudge, S.R., and Todd, P. (1998). Electrokinetic demixing of biphasic aqueous systems 3. Drop electrophoretic mobilities and demixing rates. Biotechnology Progress. 14: 922-930.

RaghavaRao, K.S.M.S., Guinn, M.R., and Todd, P. (1998). Recent developments in aqueous two-phase extraction in bioprocessing. Separation and Purification Methods. 27(1): 1-49.

Scovazzo, P., Burgos, J., Hoehn, A., and Todd, P. (1998) Hydrophilic membrane-based humidity control. J. Membrane Sci. 149: 69-81.

Simske, S.J., Bateman, T.A., Ferguson, V.L., Ayers, R.A., Dunstan, C.R. (1998) “Effects of osteoprotegerin on the sciatic nerve crush model for osteoporosis”. Bone, 23:S355.

Stodieck, L.S., A. Hoehn and A.G. Heyenga, (1998) Space Flight Research Leading to the Development of Enhanced Plant Products: Results from STS-94, Space Technology & Applications International Forum (STAIF – 98)

Stodieck, L.S., T. Bateman, R. Ayers, V. Ferguson and S. Simske (1998) Benefits Attained from Space Flight in the Pre-clinical Evaluation of Candidate Drugs, Space Technology & Applications International Forum (STAIF - 98), AIP Proc. 420

Todd, P., Klaus, D.M., Stodieck, L.S., Smith, J., Staehelin, A., Kacena, M., Manfredi, B. and Bukhari, A. (1998): “Cellular Responses to Gravity: Extracellular, Intracellular and In-Between”. Adv. Space Res. 21 (8/9): 1263-1268.

Urban, J. E. (1998). Microgravity effects on magnetotactic bacteria. Space Technol. Appl. Intl. Forum – 1998. Am. Inst. Physics. Conference. Proc. 420. Pp. 761-764

Zhao, K., Fattaey, H.K., Quinton, T.M., and Johnson, T.C. (1998) Inhibition of cyclin D-cdk activity in cell cycle arrest of Swiss 3T3 cells by CeReS-18, a novel cell regulatory sialoglycopeptide. Exper. Cell Res. 244: 295-301.

1997

Bateman TA, Ayers RA, Spetzler ML, Simske SJ, Zimmerman RJ (1997) Effects of spaceflight and insulin-like growth factor-1 on rat bone properties. Space Tech. Appl. Int. Forum '97, AIP Proc., 901-906.

Ferguson, VL, Bateman, TA, Ayers, RA, Zimmerman, RJ, Simske, SJ (1997) Effects of tail suspension and insulin-like growth factor-1 on mouse bone mechanical properties. Gravit Space Bio Bul 11:17.

Hanna, D.S., M.B. Horner, H. Ashraf, and A. Hoehn (1997): Optimizing and Integrating Thermal Control Systems for Space Life Sciences Hardware. SAE paper 97-2543, 27th International Conference on Environmental Systems ICES, July 14-17, 1997, Lake Tahoe.

Hoehn, A., D.J. Chamberlain, S.W. Forsyth, D.S Hanna, G. Heyenga, M.B. Horner, M.H. Kliss, P. Scovazzo, L.S. Stodieck, P.W. Todd (1997). On-orbit and Ground Performance of the PGBA Plant Growth Facility. SAE paper 97-2366, 27th International Conference on Environmental Systems ICES, July 14-17, 1997, Lake Tahoe.

Hoehn, A., D.J. Chamberlain, S.W. Forsyth, D.S. Hanna, M.B. Horner, P. Scovazzo, J.D. Smith, L.S. Stodieck, P. Todd, A.G. Heyenga, M.H. Kliss, R. Bula and R. Yetka (1997): "10 Day Flight Performance of the Plant Generic BioProcessing Apparatus (PGBA) Plant Growth Facility Aboard STS-77". In: Proceedings, Space Technology & Applications International Forum (STAIF-97), Albuquerque, NM., January 26-30, 1997

Horner, M. Hoehn, A., Scovazzo, P., Ashraf, H. and Hanna, D. (1997) "Optimizing and Integrating Thermal Control Systems for Space Life Sciences Hardware", SAE Paper no. 97-2543, presented at The 27th International Conference on Environmental Systems, Lake Tahoe, NV, July 14-17, 1997.

Kacena, M.A., Leonard, P.E., Todd, P., and Luttges, M.W. (1997): Low Gravity and Inertial Effects on the Growth of E. coli and B. subtilis in Semi-Solid Media. Av. Space and Environ. Med 68(12): 1104-1108.

Kacena, M.A. and Todd, P. (1997) Growth Characteristics of E. coli and B. subtilis Cultured on Agar Substrate in Microgravity. Microgravity Sci. Technol. X/1: 58-62

Klaus, D., Simske, S., Todd, P. and Stodieck, L. (1997): Investigation of Space Flight Effects on Escherichia coli and a Proposed Model of Underlying Physical Parameters. Microbiology, 143 (2): 449-455.

Pecaut MJ, Simske SJ, Fleshner M, Zimmerman R (1997) The effects of spaceflight and insulin-like growth factor-1 on the T-cell and macrophage populations. Space Tech. Appl. Int. Forum '97, 907-913.

Roedersheimer, M.T., Bateman, T.A., Simske, S.J., (1997). “Effect of gravity and diffusion interface proximity on the morphology of collagen gels”. J. Biomed. Mater.Res., 37:276-284.

Scovazzo, P., P. Todd, J. Burgos, N. Lattarulo and A. Hoehn. (1997). Membrane-basaed humidity control in microgravity: A comparison of membrane materials and design equations. SAE Technical Paper Series 972275, SAE International, Warrendale, PA

Simske SJ, Broz JJ, Fleet ML, Bateman TA (1997) The effects of two-week suspension on mouse bone metabolism. Bone,

Simske, S.J., Ayers, R.A., Bateman, T.A., (1997) “Porous materials for bone engineering”. In: Liu, D.-M., Dixit, V. (eds.) Materials Science Forum, Vol. 250: Porous Materials for Tissue Engineering, Transtech, Enfield, NH, pp. 151-182.

Smith, J.D., Todd, P., and Staehelin, L.A., (1997): "Modulation of statolith mass and grouping in white clover (Trifolium repens) grown in 1-g, microgravity and on the clinostat". The Plant Journal, 12 (6): 1361-1373.

Sportiello, M., P. Todd, Z. R. Korszun, P. H. Tran and J. M. Cassanto. (1997) Lysozyme crystallization in low gravity: Crystal quality, g-forces and video analysis. Spacebound Proceedings

1996

Bateman, TA, Ayers, RA, Simske, SJ, Bush, LL, Ferguson, VL (1996) Effects of spaceflight and insulin-like growth factor-1 on rat bone mechanical properties. Gravit Space Bio Bul 10:16.

Campbell, J., Pecaut, M. and Luttges, M. (1996) Prevalence and Arrangement of Lignified Vascular Elements in 6-day-old Alfalfa (Medicago sative L.) Seedlings raised in Reduced Gravity. J. Plant Physiol., Vol. 149 pp. 539-547.

Heyenga, A.G., A. Hoehn, D.J. Chamberlain, J.D. Smith, M.H. Kliss, P.W. Todd, and L.S. Stodieck (1996): "Growth and Development of Plants in the Plant Generic BioProcessing Apparatus on Shuttle Flight STS-77". Annual Meeting, American Society of Gravitational and Space Biology. In: Gravitational and Space Biology Bulletin 10(1), p. 34.

Johnson, T.C. and Fattaey, H.K. (1996) Applications for CeReS-18, a novel cell growth inhibitor, for the stabilization of cell populations in the microgravity environment. Amer. Soc. for Gravitat. and Space Biol. Bull. 10:29.

Johnson, T., P. Todd and L. S. Stodieck. Microgravity: New opportunities to facilitate biotechnology development. American Institute of Physics Conf. Proc. 361, Woodbury, NY (1996) pp. 77-81.

Konagurthu, S., W. B. Krantz and P. Todd. (1996) Use of low g to test alternative hypotheses for macrovoid growth in polymeric membranes. Proc. of Euromembrane '95, Vol. 1, 256-261.

Manfredi, B. (1996). Effects of Space Flight on the Growth and Development of Escherichia coli and Bacillus subtilus in Liquid Suspension and of Pseudomonas aeruginosa Biofilm. Masters Thesis, University of ŷ���ڱ���Ƶ, Boulder

Roedersheimer, M.T., Nunes, C.R., and Simske, S.J. (1996) Collagenase digestion of bone fragments in microgravity. Biotechnology and Bioengineering 50: 211-216

Sterrett, K.S., C.L. Edelen, M.W. Luttges, S.J. Simske, and H. Patiño (1996) A Study of Saccharomyces uvarum Fermentation in a Microgravity Environment, MBAA Technical Quarterly, 33 (1): 33-38

Sygusch, J., R. Coulombe, J. M. Cassanto, M. G. Sportiello and P. Todd. (1996) Protein crystallization in low gravity by step gradient diffusion method. J. Cryst. Growth. 162, 167-172.

Todd, P. and D. M. Klaus (1996) Theories and models on the biology of cells in space. Adv. Space Res. 17(6/7), 3-10

Todd, P., H. J. Anton, P. W. Barlow, R. Gerzer, J.-M. Heim, R. Hemmersbach-Krause, K. Slenzke, E. Kordyum, P. J. Duke and A. M. Duyprat, Eds. (1996) Life and Gravity: Physiological and Morphological Responses. Adv. Space Res. 17, No. (6/7):

Wang, H., S. Zeng, M. Loewenberg, P. Todd and R. H. Davis. (1996): Cell and particle interactions and aggregation during electrophoretic motion. Third Microgravity Fluid Physics Conf., NASA Conf. Pub. 3238, pp. 737-742.

1995

Adams, W.W. III; Hoehn, A.; Demmig-Adams, B. (1995) “Chilling temperatures and the xanthophyll cycle. A comparison of warm-grown and overwintering spinach.” Australian journal of plant physiology. {Melbourne, Commonwealth Scientific and Industrial Research Organization. Vol.22, no. 1: p. 75-85.

Armstrong, J.W., Gerren, R.A., and Chapes, S.K., (1995). The effect of space and parabolic flight on macrophage hematopoiesis and function. Experimental Cell Research, Vol. 216, pp. 160-168.

Bateman, TA, Ayers, RA, Nunes, CR, Simske, SJ (1995) Effects of spaceflight and pegulated human recombinant interleukin-2 on rat bone mechanical properties. ASGSB Bul 9:20.

Fleet ML, Simske SJ, Hoehn A, Schmeister TA, Luttges MW. (1995) “An autonomous module for supporting mice during spaceflight.” Microgravity Sci Technol. (1):62-67.

Gallegos, G. L., Hilaire, E. M., Peterson, B. V., Brown, C. S. and Guikema, J. A. (1995) Effects of Microgravity and Clinorotation on Stress Ethylene Production in Two Starchless Mutants of Arabidopsis thaliana. Journal of Gravitational Physiology, 2(1), pp. 153-154.

Gallegos, G. L., Odom, W. R. and Guikema, J. A. (1995) Effect of Microgravity on Stress Ethylene and Carbon Dioxide Production in Sweet Clover (Melilotus alba L). Journal of Gravitational Physiology, 2(1), pp. 155-156.

Gallegos, G. L., Peterson, B. V., Brown, C. S. and Guikema, J. A. (1995) Effects of Stress Ethylene Inhibitors on Sweet Clover (Melilotus alba L) Seedling Growth in Microgravity. Journal of Gravitational Physiology, 2(1), pp. 151-152.

Hilaire, E., Brown, C.S. and Guikema, J. A. (1995) Clinorotation Affects Soybean Seedling Morphology. Journal of Gravitational Physiology, 2(1) pp. 149-150.

Hilaire, E., Paulsen, A. Q., Brown, C. S. and Guikema, J. A. (1995) Cortical Microtubules in Sweet Clover Columella Cells Developed in Microgravity. Plant Cell Physiology, Vol. 36(7), pp. 1387-1392.

Hilaire, E., Paulsen, A. Q., Brown, C. S. and Guikema, J. A. (1995) Effects of Clinorotation and Microgravity on Sweet Clover Columella Cells Treated with Cytochalasin D. Physiologia Plantarum, Vol. 95, pp. 267-273.

Hilaire, E., Paulsen, A. Q., Brown, C. S. and Guikema, J. A. (1995) Microgravity and Clinorotation Cause Redistribution of Free Calcium in Sweet Clover Columella Cells. Plant and Cell Physiology, Vol. 36(5), pp. 831-837.

Hilaire, E., Paulsen, A. Q., Brown, C. S. and Guikema, J. A. (1995) Plastid Distribution in Columella Cells of a Starchless arabidopsis Mutant Grown in Microgravity (STS-63). ASGSB Bulletin, Vol. 9(1), p. 6.

Marchin, G. L., Silverstein, J., and Brion, G. M. (1995). Effect of microgravity on Escherichia coli and MS-2 bacteriophage disinfection by iodinated resin. Acta Astronautica

Nunes, C.R., Roedersheimer, M.T., Simske, S.J., and Luttges, M.W. (1995). Effect of microgravity, temperature, and concentration on fibrin and collagen assembly. Microgravity Sci. Technol., Vol. VIII/2, pp. 125-130.

Rosowski, J.R., Gouthro, M.A., Schmidt, K.K., Klement, B.J. and Spooner, B.S. (1995). Effect of Microgravity and Hypergravity on Embryo Axis Alignment During Postencystment Embryogenesis in Artemia francisicana. J. Crustacean Biology. 15(4): 625-632.

Simske, S.J., Broz, J.J., and Luttges, M.W. (1995). Effect of suspension on mouse bone microhardness. Journal of Material Science: Materials in Medicine, Vol. 6, pp. 486-491.

Simske, S.J., and Luttges, M.W. (1995). Suspension osteopenia in mice: Whole body electromagnetic field effects. Bioelectromagnetics, Vol. 16, pp. 152-159.

Urban, J.E., Gerren, R., and Zoelle, J. (1995). Effects of microgravity on the binding of acetylsalicylic acid by Rhizobium leguminosarum by trifolii. Acta Astronautica, Vol. 36, No. 2, pp. 129-133.

1994

Abts, K. J., Dittmer, L. N., Hoehn, A. and Luttges, M. W. (1994) Stress-Produced Ethylene Effects on Alfalfa, Clover, and Lettuce Seedlings Grown for One and Two Weeks in Microgravity. 10th Annual Meeting, American Society of Gravitational and Space Biology, ASGSB, October 20-23, 1993. ASGSB Bulletin 8(1): p. 15.

Armstrong, J.W., Balch, S., and Chapes, S.K. (1994). Interleukin-2 therapy reverses some immunosuppressive effects of skeletal unloading. American Physiological Society, Vol. 77(2), pp. 584-589.

Chapes, S.K., Morrison, D.R., Guikema, J.A., Lewis, M.L., and Spooner, B.S. (1994). Production and action of cytokines in space. Adv. Space Res., Vol. 14, No. 8, pp. 5-9.

Hoehn, A., Luttges, M. W. and Stodieck, L. S. (1994) Plant-Module for Autonomous Space Support (P-MASS). Advances in Space Research, 14(11), p. 53.

Hoehn, A., Kliss, M. H., Luttges, M. W., Robinson, M. C. and Stodieck, L. S. (1994) P-MASS and P-GBA: Two New Hardware Designs for Growing Plants in Space. 24th International Conference on Environmental Systems, ICES. SAE-94-1545.

Hoehn, A., Luttges, M. W. and Stodieck, L. S. (1994) Seed Germination and Early Plant Morphology- Results from Three Microgravity Missions. 24th International Conference on Environmental Systems (ICES) SAE-94-1545.

Kacena, M.A., Leonard, P.E., Klaus, D.M., Simske, S.J., Luttges, M.W. (1994): “The effect of microgravity on E. coli growth rates under suspension and solid agar conditions” ASGSB Bulletin, 8 (1): p.18.

Klaus, D.M. (1994): Effects of Space Flight on the Growth and Development of Escherichia coli, Doctoral Thesis, University of ŷ���ڱ���Ƶ, Boulder.

Klaus, D. M., Luttges, M. W. and Stodieck, L. S. (1994): Investigation of Space Flight Effects on Escherichia coli Growth. 24th International Conference on Environmental Systems Proceedings, SAE Technical Paper 941260.

Klement, B.J. and B.S. Spooner (1994) Pre-metatarsal skeletal development in tissue culture at unit- and microgravity. J. Exp. Zool. 269:230-241.

Luttges, M.W., Stodieck, L., and Klaus, D.M. (1994): Four Educational Programs in Space Life Sciences. Adv. Space Research, 14 (8): 439-446

Moos, P.J., Fattaey, H.K., and Johnson, T.C. (1994). Cell proliferation inhibition in reduced gravity. Experimental Cell Research, Vol. 213, pp. 458-462.

Pollmann, K.W., Stodieck, L.S. and Luttges, M.W. (1994) Hydrodynamically Induced Fluid Transfer and Non-convective Double-diffusion in Microgravity Sliding Solvent Diffusion Cells. Microgravity Sci. Technol. VII/1: 50-59.

Simske, S.J., Broz, J.J., Fleet, M.L., Schmeister, T.A., Gayles, E.C., and Luttges, M.W. (1994) Contribution of dietary and loading changes to the effects of suspension on mouse femora. Journal of Experimental Zoology, Vol. 269:277-285.

Simske, S.J., and Luttges, M.W. (1994). Effect of microgravity on collagenase deproteinization and EDTA decalcification of bone fragments. Microgravity Sci. Technol., Vol. VII/3, 266-269.

Simske, S.J., Schmeister, T.A., Fleet, M.L., Broz, J.J., Gayles, E.C., and Luttges, M.W. (1994). An experimental model for combined neural, muscular, and skeletal degeneration. Journal of Neuromusculoskeletal System, Vol. 2, No. 3, pp. 116-123.

Simske, S.J., Luttges, M.W., Allen, K.A., and Gayles, E.C. (1994). The role of sex and genotype on antiorthostatic suspension effects on the mouse peripheral skeleton. Aviation, Space and Environmental Medicine, pp. 123-133.

Spooner, B.S., Metcalf, J., DeBell, L., Paulsen, A., Noren, W. and Guikema, J.A. (1994). Development of Brine Shrimp Artemia is Accelerated During Spaceflight. J. Experimental Zoology, 269: 253-262.

Spooner, B.S., Debell, L.K., Armbrust, L., Guikema, J.A., Metcalf, J.A., and Paulsen, A. (1994): Embryogenesis, hatching and larval development of Artemia during orbital spaceflight, Adv. Space Res. Vol. 14, No. 8, pp. (8)229-(8)238.

Todd, P. (1994) Mechanical Analysis of Statolith Action in Roots and Rhizoids. Advances in Space Research, 14(8), pp. 121-124.

Woods, K.M. and Chapes, S.K. (1994). Abrogation of TNF-mediated cytotoxicity by space flight involves protein kinase C. Experimental Cell Research, Vol. 211, pp. 171-174.

1993

Armstrong, J.W., Nelson, K.A., Simske, S.J., Luttges, M.W., Iandolo, J.J., and Chapes, S.K. (1993). Skeletal unloading causes organ-specific changes in immune cell responses. J. Appl. Physiol., 75:2734-2739.

Chang, D., Paulsen, A., Johnson, T.C. and Consigli, R.A. (1993) Virus protein assembly in microgravity, Adv. Space Res., 13: 251-257.

Chapes, S.K., Mastro, A.M., Sonnenfield, G.S. and Berry, W.D. (1993). Antiorthostatic suspension as a model for the effects of space flight on the immune system. J. Leuk. Biol., 54: 227-235

Chapes, S.K., Woods, K.M., and Armstrong, J.W. (1993). Ground-based experiments complement microgravity flight opportunities in the investigation of the effects of space flight on the immune response: Is protein kinase C gravity sensitive? Trans. Kans. Acad. Sci., 96:74-79.

Claassen, D.E., van Twest, J.S. and Spooner, B.S. (1993). Formation and vesiculation of the biomembranes during spaceflight. Adv. Space Res

Conrad, G.W., Stephens, A.P. and Conrad, A.H. (1993): Preliminary observations on the effects of vector-averaged gravity on the embryonic and larval development of the gastropod mollusk, Ilyanlassa obsoleta Stimpson, Trans. Kans. Acad. Sci., 96-20-27

Faller, M. K., Hoehn, A. and Luttges, M. W. (1993) The Effect of Various Light Sources and Intensities on Chlorella Growth Rates. 9th Annual Meeting, American Society of Gravitational and Space Biology, ASGSB, October 20-23, 1993. ASGSB Bulletin 7(1): 66.

Faller, M. K., Hoehn, A. and Luttges, M. W. (1993) The Effect of Various Light Sources and Intensities on Chlorella Growth Rates. 9th Annual Meeting, American Society of Gravitational and Space Biology, ASGSB, October 20-23, 1993. ASGSB Bulletin 7(1): 66.

Fleet, M.L., Smith, J.D., Klaus, D.M., and Luttges, M.W. (1993): “Autonomous Support for Microorganism Research in Space”. AIAA/AHS/ASEE Aerospace Design Conf. Proc.

Guikema, J. A., Debell, L., Paulsen, A. Q., Spooner, B. and Wong, P. P. (1993) Clover Development During Spaceflight: A Model System. Advances Space Res., 14, 173-176.

Hoehn, A. (1993) Effects of Gravity and Light on Plant Growth and Performance in Normal and Reduced Gravity. Doctoral Thesis, University of ŷ���ڱ���Ƶ, Boulder.

Hoehn, A. and Luttges, M. W. (1993) Seed Germination and Early Plant Development of Alfalfa, Clover and Lettuce Seeds in Space. 9th Annual Meeting, American Society of Gravitational and Space Biology, ASGSB, October 20-23, 1993. ASGSB Bulletin 7(1), p. 66.

Klaus, D. and Luttges, M. (1993): “Antibiotic Effectiveness on E. coli During Space Flight” ASGSB Bulletin 7: p. 56

Klement, B.J., and Spooner, B.S., (1993). Utilization of microgravity bioreactors for differentiation of mammalian skeletal tissue, J. Cell. Biochem, 51: 252-256.

Rabin, R., Gordon, S.L., Lymn, R.W., Todd, P.W., Frey, M.A.B., and Sulzman, F.M. (1993). Effects of spaceflight on the musculoskeletal system: NIH and NASA future directions. News and features, 7: pp. 396-398.

Shah S, Faller WE, Hoehn A, Birdsong M, Luttges MW. (1993) “Characterization of fluid distribution through a porous substrate under dynamic g conditions.” Biomed Sci Instrum. ;29:401-8.

Simske, S.J., Luttges, M.W., and Allen, K.A. (1993). Effect of oral calcium and calcium + fluoride treatments on mouse bone properties during suspension. Biomimetics, 1:311-327.

Sterrett, K.S., C.L. Edelen, and M.W. Luttges (1993) Gravitational Effects on Saccharomyces cerevisae (uvarum) - Preparations for STS-60, American Society of Gravitational and Space Biology (ASGSB) Bulletin (7) 1

Woods, K. and Chapes, S.K. (1993). Space Flight diminishes tumor necrosis factor-mediated cytotoxicity. ASGSB Bul. 7:44.

1992

Abbot, M.K., Hilgenfeld, R.B. and Dennel, R.E. (1992): Drosophila melanogaster as a model system for assessing development under conditions of microgravity. Trans. Kansas Acad. of Sci., 95: 70-75.

Chapes, S.K., Morrison, D.R., Guikema, J.A., Lewis, M.L. and Spooner, B.S. (1992) Cytokine secretion by immune cells in space. J. Leuk. Biol., 52:104-110.

Conrad, G.W., and Conrad, A.H. (1992). Microtubules as key cytoskeletal elements in cellular transport and shape changes: Their expected responses to space environments. Trans. Kansas Acad. Of Sci., 95: 45-49.

Faller, M. K., Abrahamson, K. S., Hoehn, A. and Luttges, M. W. (1992) The Competing Effects of Light versus Gravity Stimulation on Growth Orientation of Lettuce, Alfalfa, and Clover. 8th Annual Meeting, American Society of Gravitational and Space Biology, ASGSB, October 24-27, 1992. ASGSB Bulletin 6(1), p. 38.

Hoehn, H. K.S. Abrahamson, S. Gomez, M. Voorhees, and M.W. Luttges (1992) Seed Germination and Early Plant Development onboard STS-50 / USML-1, ASGSB Bulletin (6)1: 38

Hoehn, A., Gomez, S. and Luttges, M. W. (1992) The Lunar CELSS Test Module. AIAA paper 92-1094, 1992 Aerospace Design Conference.

Hoehn, A., Luttges, M. W., Stodieck, L. S. and Kliss, M. H. (1992) Design and Evaluation of a Payload to Support Plant Growth Onboard COMET 1. 22nd International Conference on Environmental Systems, ICES, July 13-16, 1992. SAE-92-1389.

Hoehn, A., Simske, S. J. and Luttges, M. W. (1992) P-MASS - The Plant-Module for Autonomous Space Support Onboard COMET 1. Proceedings, International Conference on Life Support and Biospherics, February 18-20, 1992. pp. 579-588.

Klaus, D., and Luttges, M. (1992): “Metabolic Adaptation of E. coli in Microgravity” ASGSB Bulletin, 6: p. 36

Kopydlowski, K.M., McVey, D.S., Woods, C.M., Iandolo, J.J. and Chapes, S.K. (1992). Effects of antiorthostatic suspension and corticosterone on macrophage and spleen cell function. J. Leuk. Biol., 52: 202-208.

Luttges MW (1992) Recognizing and optimizing flight opportunities with hardware and life sciences limitations. Transactions of the Kansas Academy of Science, 95:76-86.

Luttges, M. W., Stodieck, L. S. and Hoehn, A. (1992) Plant Module for Autonomous Space Support. World Space Congress - Book of Abstracts, Session F4.1-M1.09, p. 593.

Shah, S., Hoehn, A., Faller, W. E., Birdsong, M. and Luttges, M. W. (1992) A Plant Nutrient Monitoring System (PNMS). 8th Annual Meeting, American Society of Gravitational and Space Biology, ASGSB, October 24-27, 1992. ASGSB Bulletin 6(1), p. 36.

Simske, S.J., Guerra, K.M., Greenburg, A.R., and Luttges, M.W. (1992). The physical and mechanical effect of suspension-induced osteopenia on mouse long bones. J. Biomechanics, 25: no. 5, pp. 489-499.

Spooner, B.S., Debell, L., Hawkins, L., Metcalf, J. and Guikema, J.A. (1992): Brine shrimp development in space: Ground-based data to shuttle flight results. Trans. Kansas Acad. of Sci. 95: 87-92.

Stewart, R.M., Todd, P., Cole, K.D. and Morrison, D.R. (1992) Further analysis of human kidney cell populations separated on the space shuttle. Advances in Space Research, 12 (5): pp. 223-229

Todd, P. (1992): Gravity and the mammalian cell. In: Physical Forces and the Mammalian Cell J. Frangor (ed.), Academic Press: 347-381.

1991

Abrahamson, K.S., J.T. Lisec, J.A. Derby, S.J. Simske, and M.W. Luttges (1991) Effects of 6 Day Weightlessness on Leguminous Sprouts, ASGSB Bulletin, (5)

Faller, M. K., Hoehn, A. and Luttges, M. W. (1991) Light Emitting Diodes as an Alternative Light Source for Algal Systems. 7th Annual Meeting, American Society of Gravitational and Space Biology, ASGSB, October 17-20, 1991. ASGSB Bulletin 5(1), p. 60.

Klaus, D., and Luttges, M. (1991): “Metabolic Adaptation of E. coli in Microgravity” ASGSB Bulletin, 5: p. 58

Simske, S.J., Greenburg, A.R., and Luttges, M.W. (1991). Tail suspension induced osteopenia in mouse femora: An animal model for microgravity exposure. J. Mat. Sci. Mat. Med. 2: 43-50.

Simske, S.J., Wachtel, H. and Luttges, M.W. (1991). Effect of localized pulsed electromagnetic fields on tail-suspension osteopenia in growing mice. Bioelectromagnetics 12: 101-116.

Simske, S.J., Greenburg, A.R., and Luttges, M.W. (1991). Effects of suspension-induced osteopenia on the mechanical behavior of mouse long bones. Journal of Materials Science: Materials in Medicine, 2(1): p. 43.

1990

Day, M., K. Abrahamson, J. Lisec, and M. Luttges, (1990) Gravitropic Response of Salad Type Sprouts, ASGSB Bulletin 4(1)

Day, M., Thomas, T., Johnson, S. A. and Luttges, M. W. (1990) Seed Sprout Production: Consumables and a Foundation for Higher Plant Growth in Space. Controlled Ecological Life Support Systems: CELSS 1989 Workshop, NASA-TM-102277.

Hoehn, A. and Luttges, M. W. (1990) The ŷ���ڱ���Ƶ Salad Machine: Key Technologies for Plant Production in Space. 6th Annual Meeting, American Society of Gravitational and Space Biology, ASGSB, November 2-5, 1990. ASGSB Bulletin 4(1), p. 69.

Hoehn, A. and Luttges, M. W. (1990) Tuning the Efficiencies of Plant Lighting Systems - From Primary Energy to Edible Biomass: The LED as an Alternative Light Source. Proceedings, 4th European Symposium Life Sciences Research in Space, ESA-SP-307, pp. 449-454.

Layne, C.S. and Spooner, B.S. (1990) EMG Analysis of human postural responses during parabolic flight microgravity episodes. Aviation, Space and Environ. Medicine 61: 994-998

Marchin, G. L. (1990) Application of the pentaiodide strong base resin disinfectant to the U.S. Space Program, Salem MA, Proc. 20th ICES Conference, pp. 1-5.

Spooner, B.S., Guikema, J.A. and Barnes G. (1990) Binding of alpha-fetoprotein by immobilized monoclonal antibodies during episodes of zero-gravity obtained by parabolic flight. Aviation, Space & Environ. Med. 61: 725-728.

1989

Hoehn, A. and Luttges, M. W. (1989) LED- A Challenging Opportunity for Artificial Plant Lighting. 5th Annual Meeting, American Society of Gravitational and Space Biology, ASGSB Bulletin 3(1), p. 80.